The “Friendly visitor” program data: A reply to Denney

Conclusion In summary, Denney's failure to obtain the original results with her reanalyses can be attributed to the fact that she (a) scored some variables differently, (b) included an inappropriate subjects who was not entered into the original analyses, (c) excluded appropriate subjects who were used in the original analyses, (d) included an additional invalid dependent measure previously dicarded, and (e) may have used a different residualization algorithm. In view of these differences, it is not surprising that the multivariate and unvariate results that she obtained were different from those originally reported.We hope that now the procedural differences that account for the inconsistencies alleged by Denney are clear.     

Environmental topography and postural control demands shape aging-associated decrements in spatial navigation performance

This study tests the hypothesis that aging-induced cognitive permeation of sensorimotor functions contributes to adult age differences in spatial navigation performance. Virtual maze-like museums were projected in front of a treadmill. Sixteen 20-30-year-old men and sixteen 60-70-year-old men performed a way-finding task in city-block or variable topographies while walking with or without support. Walking support attenuated age-related decrements in navigational learning. Navigation load increased trunk-angle variability for older adults only. Age differences in spatial knowledge persisted despite perfect place-finding performance. City-block topography was easier than variable topography for younger adults only, indicating age-related differences in reliance on spatial relational learning. Attempts at supporting older adults' navigation performance should consider sensorimotor/cognitive interactions and qualitative differences in navigational activity.     

Computerized adaptive testing,anxiety levels,and gender differences

This study compares the amount of test anxiety experienced on a computerized adaptive test (CAT) to a paper-and-pencil test (P&P), as well as the state test anxiety experienced between males and females. Ninety-four middle school CAT examinees were compared to 65 middle school P&P examinees on their responses to the State-Trait Anxiety Inventory for Children (STAIC) after taking a standardized achievement test. Results of a multiple regression showed that P&P examinees had a higher mean STAIC score than CAT examinees after controlling for trait test anxiety and computer anxiety. Evidence of neither a main nor a moderator effect of gender was found. However, a subsequent path analysis gave evidence of an indirect effect of gender on STAIC score mediated by trait test anxiety. Results are discussed in the context of stereotype threat and the implications for the use of CAT in schools, given the digital divide between race and socioeconomic status. Recommendations for future research and practice are offered.     

Eye movements in reading: Old questions and new directions

Trends in the articles reported in this volume are identified: (1) landing position effects, (2) word skipping, (3) parafoveal‐on‐foveal effects, (4) eye movement control, and (5) eye movements and word identification. Each of these issues is discussed in the context of prior research on the issue. We also identify some issues that are not included in the present set of articles, as well as some research questions that need further attention.     

Disability, Connectivity and Transgressing the Autonomous Body

This paper explores the interconnectedness of persons with disabilities, technologies and the environment by problematizing Western notions of the independent, autonomous subject. Drawing from Deleuze and Guattari's reconfiguration of the static subject as active becoming, prevailing discourses valorizing independence are critiqued as contributing to the marginalization of bodies marked as disabled. Three examples of disability "dependencies"-man-dog, man-machine, and woman-woman connectivities-are used to illustrate that subjectivity is partial and transitory. Disability connectivity thus serves a signpost for an expanded understanding of subjectivity and suggests a radically altered ethics that is no longer premised on individual rights.     

Prenatal cortisol, prematurity and low birthweight

Three hundred depressed pregnant women were recruited at approximately 20 weeks gestation. They were then divided by a median split into high and low urinary cortisol level groups. The high cortisol group had higher CES-D depression scores and higher inhibition (BIS) scores prenatally. Their fetuses had smaller head circumference, abdominal circumference, biparietal diameter and fetal weight. The high cortisol group neonates were shorter gestational age and lower birthweight and they had lower Brazelton habituation and higher Brazelton reflex scores. Discriminant function analyses suggested that cortisol levels more accurately classified short gestation and low birthweight groups than CES-D depression scores.     

Prenatal paternal depression

Prenatal depressive symptoms, anxiety, anger and daily hassles were investigated in 156 depressed and non-depressed pregnant women and their depressed and non-depressed partners (fathers-to-be). Depressed versus non-depressed fathers had higher depression, anxiety and daily hassles scores. Although the pregnant women in general had lower anxiety, anger and daily hassles scores than the men, the scores on the measures for depressed fathers and depressed mothers did not differ. Paternal depression appeared to have less effect than maternal depression on their partners’ scores. However, the similarity between the scores of depressed mothers and depressed fathers highlights the importance of screening for depression in fathers-to-be as well as mothers-to-be during pregnancy.     

Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm

The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and an airblast to the throat as the unconditioned stimulus (US). Participants were extinguished 24 h after fear conditioning. Upon presentation of unsignaled USs after extinction, participants displayed significant fear reinstatement. In summary, these procedures produced robust fear-potentiated startle, significant CS+/CS- discrimination, within-session extinction, and significant reinstatement. This is the first demonstration of fear extinction and reinstatement in humans using startle measures.     

Vanishing white matter disease: a review with focus on its genetics

Leukoencephalopathy with vanishing white matter (VWM) is an autosomal recessive brain disorder, most often with a childhood onset. Magnetic resonance imaging and spectroscopy indicate that, with time, increasing amounts of cerebral white matter vanish and are replaced by fluid. Autopsy confirms white matter rarefaction and cystic degeneration. The process of localization and identification of the first two genes related to VWM, EIF2B5 and EIF2B2, was facilitated by two founder effects in the Dutch population. EIF2B5 and EIF2B2 encode the epsilon and beta subunits of translation initiation factor eIF2B. Soon it was shown that mutations in all five eIF2B subunit genes can cause VWM. EIF2B is essential for the initiation of translation of RNA into protein and is involved in regulation of the process, especially under stress conditions, which may explain the sensitivity to stress conditions observed in VWM patients. The pathophysiology of the disease is still poorly understood.