The subjective tempo difference between interaural and monaural sequences as a function of sequence length

Previous research has demonstrated that the subjective tempo of sequences of clicks that alternate between ears is slower than that of nonalternating sequences. Although the stimulus onset asynchronies (SOAs) between the clicks are the same in both conditions, their perceptual onset asynchronies (POAs) differ by 25 msec at all SOA values between 40 and 2,130 msec. It has been suggested that this subjective tempo difference originates only after a few clicks have been processed. The present study shows this not to be the case: The POA difference between interaural and monaural click sequences could also be established with sequences comprising only a few clicks.     

Computational aspects of the greatest lower bound to the reliability and constrained minimum trace factor analysis

In the last decade several algorithms for computing the greatest lower bound to reliability or the constrained minimum-trace communality solution in factor analysis have been developed. In this paper convergence properties of these methods are examined. Instead of using Lagrange multipliers a new theorem is applied that gives a sufficient condition for a symmetric matrix to be Gramian. Whereas computational pitfalls for two methods suggested by Woodhouse and Jackson can be constructed it is shown that a slightly modified version of one method suggested by Bentler and Woodward can safely be applied to any set of data. A uniqueness proof for the solution desired is offered.The authors are obliged to Charles Lewis and Dirk Knol for helpful comments, and to Frank Brokken and Henk Camstra for developing computer programs.     

The Concept of Abnormality in Medical Genetics

This paper explores usage of the concept ofabnormality in medical genetics and proposesdirectives for more careful usage of this concept.The conceptual difficulties are first explored, thena model is developed to assess actual usage, followedby analysis of a sample of genetic textbooks andgenetics literature. It appears that fact andvaluation are often intermingled, that referencestandards used to define 'genetic abnormalities' areoften not clear and that the concept of abnormality isoften used independent of the degree of certainty withwhich the altered genetype develops into a (seriously)harmful phenotype. On the basis of these findings itis argued that more restraint and more careful use ofthe concept of genetic abnormality of medical geneticsis appropriate as well as more agreement on the use ofreference standards.     

A general solution for a class of weakly constrained linear regression problems

This paper contains a globally optimal solution for a class of functions composed of a linear regression function and a penalty function for the sum of squared regression weights. Global optimality is obtained from inequalities rather than from partial derivatives of a Lagrangian function. Applications arise in multidimensional scaling of symmetric or rectangular matrices of squared distances, in Procrustes analysis, and in ridge regression analysis. The similarity of existing solutions for these applications is explained by considering them as special cases of the general class of functions addressed.The author is obliged to Henk Kiers and Willem Heiser for helpful comments.     

On the equivalence of two oblique congruence rotation methods,and orthogonal approximations

Tucker's method of oblique congruence rotation is shown to be equivalent to a procedure by Meredith. This implies that Monte Carlo studies on congruence by Nesselroade, Baltes and Labouvie and by Korth and Tucker are highly comparable. The problem of rotating two matrices orthogonally to maximal congruence has not yet been solved. An approximate solution to this problem can be derived from Tucker's method. Even better results can be obtained from a Procrustes rotation followed by rotation to simple structure.     

A generalization of Takane's algorithm for dedicom

An algorithm is described for fitting the DEDICOM model for the analysis of asymmetric data matrices. This algorithm generalizes an algorithm suggested by Takane in that it uses a damping parameter in the iterative process. Takane's algorithm does not always converge monotonically. Based on the generalized algorithm, a modification of Takane's algorithm is suggested such that this modified algorithm converges monotonically. It is suggested to choose as starting configurations for the algorithm those configurations that yield closed-form solutions in some special cases. Finally, a sufficient condition is described for monotonic convergence of Takane's original algorithm.Financial Support by the Netherlands organization for scientific research (NWO) is gratefully acknowledged. The authors are obliged to Richard Harshman.     

Physiological correlates of intellectual function in children with sickle cell disease: hypoxaemia, hyperaemia and brain infarction

Lowered intelligence relative to controls is evident by mid-childhood in children with sickle cell disease. There is consensus that brain infarct contributes to this deficit, but the subtle lowering of IQ in children with normal MRI scans might be accounted for by chronic systemic complications leading to insufficient oxygen delivery to the brain. We investigated the relationship between daytime oxyhaemoglobin saturation (SpO2), cerebral blood flow velocity (CBFV) and intellectual function (IQ) using path-analysis in 30 adolescents with sickle cell disease (mean age 17.4 years, SD 4.2). Initial analyses revealed that the association between SpO2 and Full Scale IQ (FSIQ) was fully mediated by increased CBFV, whereby SpO2 was negatively correlated with CBFV and CBFV was negatively correlated with FSIQ, i.e. decreases in oxygen saturation are associated with increases in velocity, and increased velocity is associated with lowered IQ scores. The mediated relationship suggests that lowered IQ may be a function of abnormal oxygen delivery to the brain. Further analyses showed that the association between CBFV and IQ was significant for verbal but not for performance IQ. The pathophysiology characteristic of SCD can interfere with brain function and constrain intellectual development, even in the absence of an infarct. This supports the hypothesis that lowered intellectual function is partly explained by chronic hypoxia, and has wider implications for our understanding of SCD pathophysiology.