Who Is at Risk for Psychological Distress in Genetic Testing Programs for Hereditary Cancer Disorders?

Presymptomatic identification of disease gene carriers is becoming an increasingly common part of the clinical management of hereditary cancer disorders. With an expected increase in the number of requests for DNA testing and the limited resources for counseling, the amount of time genetic counselors are able to spend with test candidates will decrease. It is therefore important for counselors to identify persons at risk for psychological distress. Based on a review of experiences with Huntington disease and cancer patients, we describe factors likely to evoke distress in genetic cancer candidates. We also discuss the sometimes widely different ways that test candidates and their partners respond to genetic testing. By exploring risk factors for distress in relevant domains of the research, we can offer counselors guidelines for determining who may need extra counseling.     

An alternating least squares method for the weighted approximation of a symmetric matrix

Bailey and Gower examined the least squares approximationC to a symmetric matrixB, when the squared discrepancies for diagonal elements receive specific nonunit weights. They focussed on mathematical properties of the optimalC, in constrained and unconstrained cases, rather than on how to obtainC for any givenB. In the present paper a computational solution is given for the case whereC is constrained to be positive semidefinite and of a fixed rankr or less. The solution is based on weakly constrained linear regression analysis.The authors are obliged to John C. Gower for stimulating this research.     

全球生命伦理学

探讨生命伦理学的起源,并阐述了不同理论支持者的观点,发现无论准确的生命伦理学历史起源是什么,目前生命伦理学已经变成了一种真正的全球现象。它在全世界具有重要的意义,因为人类不仅仅是欧洲人或亚洲人,也是世界公民和一个全球道德共同体的成员。生命伦理学对任何地方、任何人都是重要的,并不是因为它是"拿来"的,而是因为它提供了一个普遍的框架去解释和管理正在经历的变化,这个变化包括了目前所有的国家和文化。然而,这个框架的解释和应用必须依据本土环境。因此,现代生命伦理学具有全球性和本土特征的特点。     

Process arrangements for variety,retention, and selection

This article argues that process management aimed at introducing variety, retention, and selection into complex decision-making processes can make a substantial contribution to improving them. It also describes process arrangements for variety, retention, and selection. He received his Ph. D. in public administration at Erasmus University, Rotterdam. He is also program director at the Netherlands School of Public Administration and director of the TUD research program on multi actor systems. His research concerns networks and network-organizations, with a strong focus on governance and management issues in networks. He is the author on a number of internationally recognized books on these issues. His conceptual approach of these issues has been applied in research on the open source movement, frequency allocation, the design of policy instruments and mediation (e.g. interconnection disputes). He is program leader of the Bsik research program Next Generation Infrastructures. He holds the post of chair research within the faculty.     

Applying the job demands–resources model to the work–home interface: A study among medical residents and their partners

Work–home interference (WHI) is a prevalent problem because most employees have substantial family responsibilities on top of their work demands. The present study hypothesized that high job demands in combination with low job resources contribute to WHI. The job demands–resources (JD-R) model was used as a theoretical framework. Using a sample of 230 medical residents and their partners, our results show that the combination of high job demands (i.e., work overload, emotional and cognitive demands) and low job resources (i.e., participation in decision making, supervisory coaching, feedback, and opportunities for development) was positively related to partner ratings of the employee's WHI. When job resources were high, most job demands were not related to WHI. These findings show that the JD-R model is a conceptual framework that can be fruitfully applied to the work–family interface, adding to our understanding of which particular job designs facilitate or prevent work–home interference.     

UNESCO’s Activities in Ethics

UNESCO is an intergovernmental organization with 193 Member States. It is concerned with a broad range of issues regarding education, science and culture. It is the only UN organisation with a mandate in science. Since 1993 it is addressing ethics of science and technology, with special emphasis on bioethics. One major objective of the ethics programme is the development of international normative standards. This is particularly important since many Member States only have a limited infrastructure in bioethics, lacking expertise, educational programs, bioethics committees and legal frameworks. UNESCO has recently adopted the Universal Declaration on Bioethics and Human Rights. The focus of current activities is now on implementation of this Declaration. Three activities are discussed that aim at improving and reinforcing the ethics infrastructure in relation to science and technology: the Global Ethics Observatory, the Ethics Education Programme and the Assisting Bioethics Committees project.     

Positive and negative effects of family involvement on work-related burnout

We aimed to explain the influence of family involvement on feelings of burnout among employees who combine work and family tasks. As proxies for family involvement, we used the family structure (partner, number and age of children) and family tasks (e.g. hours spent on household chores). We compared conflict theory and enrichment theory, and investigated how well they explain the relationship between family involvement and feelings of burnout. Based on a sample of 1046 employees at 30 Dutch organizations, the results showed that the presence of young children and doing more household chores were positively related to feelings of burnout, whereas having children reduced employees’ feelings of burnout. We also investigated interaction effects of gender and gender-role norms. We conclude that family life can reduce work-related burnout and that for men, the relationship between family involvement and feelings of burnout differs depending on whether they have traditional or modern gender-role norms.     

Two instructional designs for dialogic citizenship education: An effect study

Background Despite the renewed interest in citizenship education, relatively little is known about effective ways to realize citizenship education in the classroom. In the literature on citizenship education, dialogue is considered to be a crucial element. However, there is very little, if any, empirical research into the different ways to stimulate dialogue. Aim The main aim of this study is to arrive at an understanding of how citizenship education can be integrated in history classes. The focus is on the effect of a dialogic approach to citizenship education on students' ability to justify an opinion on moral issues. Sample Four hundred and eighty‐two students in the eighth grade of secondary education. Methods Two curriculum units for dialogic citizenship education were developed and implemented. The two curriculum units differed in the balance between group work and whole‐class teaching. Students' ability to justify an opinion was assessed by means of short essays written by students on a moral issue. The effectiveness of both curriculum units was compared with regular history classes. Results Students who participated in the lessons for dialogic citizenship education were able to justify their opinion better than students who participated in regular history lessons. The results further show a positive effect of the amount of group work involved. Conclusion The results of this study indicate that a dialogic approach to citizenship education as an integral part of history classes helps students to form a more profound opinion about moral issues in the subject matter. In addition, group work seems to be a more effective method to implement dialogue in the classroom than whole‐class teaching.     

Sex role orientation and dimensions of self-esteem among middle adolescents

A questionnaire study of 229 high-school students examined the relationship between sex role orientation and various dimensions of self-esteem. The results provide strong support for the masculinity model self-esteem, especially for females. Multivariate analyses of variance revealed the following: (a) females perceived themselves to be significantly more socially competent than males; (b) males perceived themselves to be more physically competent than females; (c) adolescents high on masculinity perceived themselves to be significantly more socially competent, physically competent, and to have higher general self-esteem than those low on masculinity; (d) males and females high on masculinity perceived themselves to be significantly more physically competent and to have higher general self-esteem than females low on masculinity, although males low on masculinity did not differ significantly from any of the other interaction groups. Regression analyses by gender revealed the following: (a) the contribution of masculinity to social competence was much greater for females than for males, (b) the contribution of masculinity to physical competence was much greater for females than for males, and (c) the contribution of masculinity to general self-esteem was much greater for females than for males. In summary, for males, gender may override the impact of sex role orientation, while among females the impact of sex role orientation may be accentuated.