Ethical Issues in Cancer Genetics: 1) Whose Information Is It?

This article presents and discusses four clinical cases that exemplify the complexity of ethical dilemmas concerning the provider's obligation to disclose or withhold genetic information from patients. Case 1: What is the responsibility of the cancer genetics provider to ensure that a positive test results is shared with distant relatives? Case 2: To ensure that results go to at-risk relatives, do we have the right to ignore the wishes of the designated next-of-kin? Case 3: Do we have the right to reveal a familial BRCA1 mutation to a patient's relative, who is at 50% risk? Case 4: Do we have an obligation to reveal that a patient is not a blood relative and therefore, not at risk to have inherited a familial mutation? These cases form the basis for discussing the provider's dual obligations to keeping patient confidentiality and informing patients and families about risk (i.e. duty to warn). We also provide a summary of consensus points and additional discussion questions for each case.     

Time-shrinking,its propagation,and Gestalt principles

When a relatively short empty time interval is preceded by an even shorter one, its duration can be underestimated remarkably. This phenomenon, called time-shrinking, has been investigated with patterns consisting of two time intervals. In five experiments, we investigated whether underestimation of the last interval would occur when it was preceded by two time intervals. Significant underestimations of the last interval occurred in some of those patterns. The influence of the second preceding interval was dominant, but in some patterns, the first preceding interval could shrink the subjective duration of the last time interval directly. The first interval could also affect perception of the duration of the last one indirectly by shrinking the second interval, as a result of which the latter either shrank the last interval more strongly or became too short to shrink it. There were two types of temporal patterns in which the perceived duration of the last interval could not be explained by time-shrinking or its propagation through the pattern. It seemed plausible that auditory Gestalt principles invoked strong figural organizations in these patterns, which rendered the time-shrinking mechanism inoperative.     

Couple dynamics of change-resistant smoking: toward a family consultation model

Smoking is North America's leading cause of preventable morbidity and mortality. Although effective cessation treatments exist, their overall effect is modest, and they rarely reach the high-risk, health-compromised smokers who need them most. Surprisingly, despite evidence that marital relationship variables predict the success of cessation efforts, family systems ideas have had little impact on current intervention research. We review and critique the cessation literature from a systemic viewpoint, illustrate two couple-interaction patterns relevant to the maintenance of high-risk smoking, and outline a family-consultation (FAMCON) intervention for couples in which at least one partner continues to smoke despite having heart or lung disease. Taking into account ironic processes and symptom-system fit, FAMCON focuses on the immediate social context of smoking, aiming to interrupt well-intentioned "solutions" that ironically feed back to keep smoking going, and to help clients realign important relationships in ways not organized around tobacco usage. Currently in its pilot-testing phase, FAMCON is an adjunctive, complementary approach designed to include collaboration with primary-care physicians and to make smokers more amenable to other, evidence-based cessation strategies.     

Gaze behavior in audiovisual speech perception: the influence of ocular fixations on the McGurk effect

We conducted three experiments in order to examine the influence of gaze behavior and fixation on audiovisual speech perception in a task that required subjects to report the speech sound they perceived during the presentation of congruent and incongruent (McGurk) audiovisual stimuli. Experiment 1 showed that the subjects' natural gaze behavior rarely involved gaze fixations beyond the oral and ocular regions of the talker's face and that these gaze fixations did not predict the likelihood of perceiving the McGurk effect. Experiments 2 and 3 showed that manipulation of the subjects' gaze fixations within the talker's face did not influence audiovisual speech perception substantially and that it was not until the gaze was displaced beyond 10 degrees - 20 degrees from the talker's mouth that the McGurk effect was significantly lessened. Nevertheless, the effect persisted under such eccentric viewing conditions and became negligible only when the subject's gaze was directed 60 degrees eccentrically. These findings demonstrate that the analysis of high spatial frequency information afforded by direct oral foveation is not necessary for the successful processing of visual speech information.     

Global optimality of the successive Maxbet algorithm

The Maxbet method is an alternative to the method of generalized canonical correlation analysis and of Procrustes analysis. Contrary to these methods, it does not maximize the inner products (covariances) between linear composites, but also takes their sums of squares (variances) into account. It is well-known that the Maxbet algorithm, which has been proven to converge monotonically, may converge to local maxima. The present paper discusses an eigenvalue criterion which is sufficient, but not necessary for global optimality. However, in two special cases, the eigenvalue criterion is shown to be necessary and sufficient for global optimality. The first case is when there are only two data sets involved; the second case is when the inner products between all variables involved are positive, regardless of the number of data sets.The authors are obliged to Henk Kiers for critical comments on a previous draft.     

A family of association coefficients for metric scales

Four types of metric scales are distinguished: the absolute scale, the ratio scale, the difference scale and the interval scale. A general coefficient of association for two variables of the same metric scale type is developed. Some properties of this general coefficient are discussed. It is shown that the matrix containing these coefficients between any number of variables is Gramian. The general coefficient reduces to specific coefficients of association for each of the four metric scales. Two of these coefficients are well known, the product-moment correlation and Tucker's congruence coefficient. Applications of the new coefficients are discussed.     

Coefficients alpha and reliabilities of unrotated and rotated components

It has been shown by Kaiser that the sum of coefficients alpha of a set of principal components does not change when the components are transformed by an orthogonal rotation. In this paper, Kaiser's result is generalized. First, the invariance property is shown to hold for any set of orthogonal components. Next, a similar invariance property is derived for the reliability of any set of components. Both generalizations are established by considering simultaneously optimal weights for components with maximum alpha and with maximum reliability, respectively. A short-cut formula is offered to evaluate the coefficients alpha for orthogonally rotated principal components from rotation weights and eigenvalues of the correlation matrix. Finally, the greatest lower bound to reliability and a weighted version are discussed.Comments by Henk A.L. Kiers and by anonymous referees are gratefully acknowledged.     

Structuring Writing for Reading: Hypertext and the Reading Body

This paper examines some textual devices that writers may use to pre-structure the activities of their readers. HyperText Markup Language (HTML) is used as an 'explicating device' to explore how writers can provide reading instructions, and how these can be experienced by readers. Structuring devices like paragraphs and sections, and hypertextual elements like notes and references are investigated in detail. In this way, the paper aspires to contribute to 'an ethnomethodology of textual practices'     

Time-shrinking: a discontinuity in the perception of auditory temporal patterns.

Recent research at our laboratories in the field of human auditory time perception revealed that the duration of short empty time intervals (less than approximately 200 msec) is considerably underestimated if they are immediately preceded by shorter time intervals. Within a certain range, the amount of subjective time shrinking is a monotonous function of the preceding time interval; the shorter it is, the more it shrinks its successor. In the present study, the preceding interval was kept constant at 50 msec, and the following interval, for which the duration had to be judged, varied from 40 to 280 msec. The results showed that at up to 100 msec, the perceived duration increased to a much lesser extent than did the objective duration. Beyond 120 msec, the perceived duration quickly increased and reached a veridical value at 160 msec. Such a sudden change of perceived duration in a temporal pattern in which the objective duration varies gradually indicates a typical example of categorical perception. We suggest that such a categorization of the time dimension might be a clue for processes of speech and music perception.     

An efficient algorithm for TUCKALS3 on data with large numbers of observation units

A modification of the TUCKALS3 algorithm is proposed that handles three-way arrays of order I × J × K for any I. When I is much larger than JK, the modified algorithm needs less work space to store the data during the iterative part of the algorithm than does the original algorithm. Because of this and the additional feature that execution speed is higher, the modified algorithm is highly suitable for use on personal computers. This research has been made possible by a fellowship from the Royal Netherlands Academy of Arts and Sciences to the first author.