Extinction of drug cue reactivity in methamphetamine-dependent individuals

Conditioned responses to drug-related environmental cues (such as craving) play a critical role in relapse to drug use. Animal models demonstrate that repeated exposure to drug-associated cues in the absence of drug administration leads to the extinction of conditioned responses, but the few existing clinical trials focused on extinction of conditioned responses to drug-related cues in drug-dependent individuals show equivocal results. The current study examined drug-related cue reactivity and response extinction in a laboratory setting in methamphetamine-dependent individuals. Methamphetamine cue-elicited craving was extinguished during two sessions of repeated (3) within-session exposures to multi-modal (picture, video, and in-vivo) cues, with no evidence of spontaneous recovery between sessions. A trend was noted for a greater attenuation of response in participants with longer (4-7 day) inter-session intervals. These results indicate that extinction of drug cue conditioned responding occurs in methamphetamine-dependent individuals, offering promise for the development of extinction- based treatment strategies.     

No Reservations Required? Defending Anti-Nominalism

In a 2005 paper, John Burgess and Gideon Rosen offer a new argument against nominalism in the philosophy of mathematics. The argument proceeds from the thesis that mathematics is part of science, and that core existence theorems in mathematics are both accepted by mathematicians and acceptable by mathematical standards. David Liggins (2007) criticizes the argument on the grounds that no adequate interpretation of “acceptable by mathematical standards” can be given which preserves the soundness of the overall argument. In this discussion I offer a defense of the Burgess-Rosen argument against Liggins’s objection. I show how plausible versions of the argument can be constructed based on either of two interpretations of mathematical acceptability, and I locate the argument in the space of contemporary anti-nominalist views.     

A Content Analysis of Prime Time Commercials: A Contextual Framework of Gender Representation

For this content analysis we recorded a sample of 1,337 prime time commercials from the 3 major networks (ABC, CBS, and NBC) in 1998. There were 5,473 primary and secondary characters identified. Each character was coded for gender, age, acting role, and product being advertised. The findings were then compared to Bretl and Cantor (1988), the U.S. Census Bureau's 2000 population statistics, and Mediamark Research and Simmons syndicated marketing services. The commercials' producers cast their female and male characters much the same way as was done in the 1980s. Although women make most purchases of goods and services, they are still underrepresented as primary characters during most prime time commercials except for health and beauty products. Women are still cast as younger, supportive counterparts to men, and older women are still the most underrepresented group. Television commercials perpetuate traditional stereotypes of women and men.     

Common barriers to healthcare for transgender people in the U.S. Southeast

Abstract

Background: Transgender and non-binary people are more likely to face barriers to healthcare than their cisgender counterparts. The majority of work in this area centers on the experiences of transgender people in northern cities and urban enclaves, yet over 500,000 transgender people live in the U.S. Southeast.

Aims: The purpose of this study is to explore barriers to healthcare among transgender people in the U.S. Southeast.

Methods: The research team conducted four 120-minute focus groups (eligibility criteria: 18?years or older, self-identify as transgender, live in the U.S. Southeast). Participants completed a demographic questionnaire prior to the start of the focus group. Each focus group explored access to and experiences of receiving basic healthcare as a transgender person in the U.S. Southeast. Established qualitative methods were used to conduct the focus groups and data analysis.

Results: Participants (n?=?48) ranged in age from 19 to 65, with the majority identifying as trans women (43.8%) and non-binary (33.3%). The sample was racially diverse: White (50%), Black (37.5%), and Latinx or Multiracial (12.5%). Multiple barriers to care were identified: (1) fear and mistrust of providers; (2) inconsistency in access to healthcare; (3) disrespect from providers; and, (4) mistreatment due to intersecting experiences of gender, race, class, and location.

Discussion: Transgender Southerners face barriers to care at the structural, cultural, and interpersonal levels. The study results have implications for researchers, as well as providers, practices, and health care systems throughout the region.