An automatic micropipette fluid dispenser

An automatic device for repeated dispensation of a precisely controlled amount of fluid is described. The device employs a repeating micropipette powered by an electric motor geared to a rack-and-pinion drive. In our particular application, thirsty rats work for 0.2-ml shots of water delivered to a metal spout connected to a drinkometer circuit. This arrangement permits the recording of both volumetric intake and the number of licks directed at the spout.     

Philosophy of Development: Reconstructing the Foundations of Human Development and Education,edited by Wouter van Haaften,Michiel Korthals and Thomas Wren

Studies in Philosophy and Education -     

PROMPTING PATRON SAFETY BELT USE AT A SUPERMARKET

We used a reversal (ABAB) design to assess the effects of a personal prompt on safety belt usage by grocery store patrons. A personal prompt delivered by grocery carriers resulted in a 12% increase in the number of patrons exiting the parking lot with their safety belts buckled. This simple, low-cost intervention offers potential savings to society from increased safety belt use.     

Good-Enough Representations in Language Comprehension

People comprehend utterances rapidly and without conscious effort. Traditional theories assume that sentence processing is algorithmic and that meaning is derived compositionally. The language processor is believed to generate representations of the linguistic input that are complete, detailed, and accurate. However, recent findings challenge these assumptions. Investigations of the misinterpretation of both garden-path and passive sentences have yielded support for the idea that the meaning people obtain for a sentence is often not a reflection of its true content. Moreover, incorrect interpretations may persist even after syntactic reanalysis has taken place. Our good-enough approach to language comprehension holds that language processing is sometimes only partial and that semantic representations are often incomplete. Future work will elucidate the conditions under which sentence processing is simply good enough.     

Psychodynamic assessment of changes in children with autism under psychoanalytic treatment

In this article the authors report insights into autism developed through their extensive experience of psychoanalytic therapy with children with autism. The fi rst stages of body psychic development are seriously disrupted by this pathology, resulting in primitive anxieties of falling and of being liquefi ed. These anxieties are connected to the fragile development of body ego and of its related spatiotemporal organisation. The changes in children observed by the authors during the therapeutic process lead them to offer a psychodynamic assessment tool, which revolves principally around the development of body ego. After the initial state of 'severe autism', the authors describe three stages: the stage of 'recovery of the skin' (Bick); the established 'symbiotic phase', subdivided into 'vertical then horizontal splitting of the body ego'; and fi nally the stage of 'individuation'. First, the authors describe the principal psychoanalytic approaches to autism and refl ect on the links possible with nonpsychoanalytic work.     

Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses

Cyclic AMP signaling plays a central role in regulating activity at a number of synapses in the brain. We showed previously that pairing activation of receptors that inhibit adenylate cyclase (AC) and reduce the concentration of cyclic AMP, with elevation of the concentration of cyclic GMP is sufficient to elicit a presynaptically expressed form of LTD at Schaffer collateral-CA1 synapses in the hippocampus. To directly test the role of AC inhibition and G-protein signaling in LTD at these synapses, we utilized transgenic mice that express a mutant, constitutively active inhibitory G protein, Galpha(i2), in principal neurons of the forebrain. Transgene expression of Galpha(i2) markedly enhanced LTD and impaired late-phase LTP at Schaffer collateral synapses, with no associated differences in input/output relations, paired-pulse facilitation, or NMDA receptor-gated conductances. When paired with application of a type V phosphodiesterase inhibitor to elevate the concentration of intracellular cyclic GMP, constitutively active Galpha(i2) expression converted the transient depression normally caused by this treatment to an LTD that persisted after the drug was washed out. Moreover, this effect could be mimicked in control slices by pairing type V phosphodiesterase inhibitor application with application of a PKA inhibitor. Electrophysiological recordings of spontaneous excitatory postsynaptic currents and two-photon visualization of vesicular release using FM1-43 revealed that constitutively active Galpha(i2) tonically reduced basal release probability from the rapidly recycling vesicle pool of Schaffer collateral terminals. Our findings support the hypothesis that inhibitory G-protein signaling acts presynaptically to regulate release, and, when paired with elevations in the concentration of cyclic GMP, converts a transient cyclic GMP-induced depression into a long-lasting decrease in release.     

Accommodation, occlusion, and disparity matching are used to guide reaching: a comparison of actual versus virtual environments.

The authors used a virtual environment to investigate visual control of reaching and monocular and binocular perception of egocentric distance, size, and shape. With binocular vision, the results suggested use of disparity matching. This was tested and confirmed in the virtual environment by eliminating other information about contact of hand and target. Elimination of occlusion of hand by target destabilized monocular but not binocular performance. Because the virtual environment entails accommodation of an image beyond reach, the authors predicted overestimation of egocentric distances in the virtual relative to actual environment. This was confirmed. The authors used -2 diopter glasses to reduce the focal distance in the virtual environment. Overestimates were reduced by half. The authors conclude that calibration of perception is required for accurate feedforward reaching and that disparity matching is optimal visual information for calibration.     

Body posture and gender impact neural processing of power-related words

Judging others’ power facilitates successful social interaction. Both gender and body posture have been shown to influence judgments of another’s power. However, little is known about how these two cues interact when they conflict or how they influence early processing. The present study investigated this question during very early processing of power-related words using event-related potentials (ERPs). Participants viewed images of women and men in dominant and submissive postures that were quickly followed by dominant or submissive words. Gender and posture both modulated neural responses in the N2 latency range to dominant words, but for submissive words they had little impact. Thus, in the context of dual-processing theories of person perception, information extracted from both behavior (i.e., posture) and from category membership (i.e., gender) are recruited side-by-side to impact word processing.     

Attentional focus affects how events are segmented and updated in narrative reading

Readers generate situation models representing described events, but the nature of these representations may differ depending on the reading goals. We assessed whether instructions to pay attention to different situational dimensions affect how individuals structure their situation models (Exp. 1) and how they update these models when situations change (Exp. 2). In Experiment 1, participants read and segmented narrative texts into events. Some readers were oriented to pay specific attention to characters or space. Sentences containing character or spatial-location changes were perceived as event boundaries—particularly if the reader was oriented to characters or space, respectively. In Experiment 2, participants read narratives and responded to recognition probes throughout the texts. Readers who were oriented to the spatial dimension were more likely to update their situation models at spatial changes; all readers tracked the character dimension. The results from both experiments indicated that attention to individual situational dimensions influences how readers segment and update their situation models. More broadly, the results provide evidence for a global situation model updating mechanism that serves to set up new models at important narrative changes.     

Who Counts as Human? Antecedents to Androcentric Behavior

People view men as typically human, although some conditions may make this more or less likely. Language has been implicated as one factor, with masculine generic language (e.g., he used neutrally) leading to more androcentrism relative to its alternatives. However, the influence of two types of alternatives (e.g., they vs. he or she) remains unclear. The present study asked 297 male and female online participants from the United States to select typical representations of humanity from a set of White and Black male and female faces. The wording for the concept humanity was manipulated to be either a typical member of mankind, a typical human, or a typical man or woman (or woman or man). Overall, participants selected more White targets. Participants also selected more male targets, but the degree to which that was the case was affected by wording and participant’s gender. Participants, particularly male participants, in the mankind and human wording conditions were more likely to select a male target as representative, whereas in the man or woman condition, participants’ choices did not differ from chance. Thus, androcentric thinking may be more mutable than previously surmised, varying by participants’ gender and by context.