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111.
该研究采用ECM实验范式,操纵被试编码阶段加工方式,分析被试情绪状态与记忆成绩之间关系。情绪电影片段诱发被试高兴或悲伤情绪后,要求被试在学习情绪词时进行有意记忆或熟悉判断或结构判断,完成分心任务后进行自由回忆。结果发现:高兴组和悲伤组采用三种加工方式学习情绪词时均出现ECM;在高兴或悲伤状态下,被试进行结构判断学习情绪词时ECM效应量大,进行有意记忆和熟悉判断学习情绪词时ECM效应量小。 相似文献
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NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis 总被引：5，自引：0，他引：5 
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下载免费PDF全文 Shimazu K Zhao M Sakata K Akbarian S Bates B Jaenisch R Lu B 《Learning & memory (Cold Spring Harbor, N.Y.)》2006,13(3):307-315
In the adult brain, the expression of NT-3 is largely confined to the hippocampal dentate gyrus (DG), an area exhibiting significant neurogenesis. Using a conditional mutant line in which the NT-3 gene is deleted in the brain, we investigated the role of NT-3 in adult neurogenesis, hippocampal plasticity, and memory. Bromodeoxyuridine (BrdU)-labeling experiments demonstrated that differentiation, rather than proliferation, of the neuronal precursor cells (NPCs) was significantly impaired in DG lacking NT-3. Triple labeling for BrdU, the neuronal marker NeuN, and the glial marker GFAP indicated that NT-3 affects the number of newly differentiated neurons, but not glia, in DG. Field recordings revealed a selective impairment in long-term potentiation (LTP) in the lateral, but not medial perforant path-granule neuron synapses. In parallel, the NT-3 mutant mice exhibited deficits in spatial memory tasks. In addition to identifying a novel role for NT-3 in adult NPC differentiation in vivo, our study provides a potential link between neurogenesis, dentate LTP, and spatial memory. 相似文献
113.
Accumulating evidence suggests that stress‐dose corticosteroids impair fear memory in animals and humans. Corticosteroid treatment after critical illness is seen as a potential psychotropic medication by which to prevent posttraumatic stress disorder. However, individual difference in the responsiveness to stress (i.e., stress reactivity) is a factor that modulates the efficacy of corticosteroids. To understand the contribution of fear reactivity to the effect of post‐stress corticosterone, male Sprague‐Dawley rats were subjected to classical tone‐cued fear conditioning and separated into high and low reactivity (HR and LR, respectively) responder groups based on their levels of freezing during conditioning. The HR rats showed significantly higher fear responses than the LR rats during conditioning as assessed by freezing behavior. At two intervals, 30 min and 48 hr later, the HR rats still displayed more pronounced conditioned responses to cued stimuli compared with the LR rats. Moreover, in contrast to the LR rats, the enhanced fear response in the HR rats was difficult to attenuate by post‐training high‐dose corticosterone. These results suggest that fear reactivity results in stronger fear memory, and that it is difficult to disrupt this strong fear memory in the HR phenotype using monotherapy. However, the strong fear memory in the HR rats was impaired by concurrent intramedial prefrontal cortex infusion of a high dose of the dopamine D1 receptor antagonist SCH 23390 and systemic administration of corticosterone. SCH 23390 and corticosterone alone did not decrease freezing levels in the HR rats. The fear impairment induced by SCH 23390 combined with corticosterone was not attributable to the effect of these drugs on locomotor activity. This effect was not found with administration of the D2 antagonist eticlopride combined with corticosterone. Our findings demonstrate that the conditioned fear memory in individuals with high stress reactivity is difficult to disrupt using monotherapy, but that combined pharmacotherapy may be useful for treating intervention‐resistant fear. 相似文献
114.
Simon P. Liversedge Chuanli Zang Manman Zhang Xuejun Bai Guoli Yan Denis Drieghe 《Visual cognition》2014,22(3-4):441-457
Eye movements of native Chinese readers were monitored when they read sentences containing single-character target words orthogonally manipulated for frequency and visual complexity (number of strokes). Both factors yielded strong main effects on skipping probability but no interaction, with readers skipping visually simple and high frequency words more often. However, an interaction between frequency and complexity was observed on the fixation times on the target words with longer fixations for the low frequency, visually complex words. The results demonstrate that visual complexity and frequency have independent influences on saccadic targeting behaviour during Chinese reading but jointly influence fixation durations and that these two factors differently impact fixation durations and saccade targeting during reading. 相似文献
115.
Corruption is rampant around the world and can be detrimental to social justice. We aim to understand whether and how belief in a just world to self (BJW‐self) influences individuals' intentions to become involved in bribery. We measured bribery intention using hypothetical scenarios. In Study 1 and Study 2, we consistently found that BJW‐self negatively predicted bribery intention, and this pattern was mediated by perceived punishment of getting involved in bribery. We further demonstrated the causal effect of BJW‐self on bribery intention in an experiment (Study 3). These results indicate that BJW as one lay belief can be important in suppressing people's bribery intention, and perceived punishment mediates the effect of BJW on rule‐breaking behaviours. Implications for anti‐corruption policies and future research are also discussed. 相似文献
116.
John Y. H. Bai C. K. Jonas Chan Douglas Elliffe Christopher A. Podlesnik 《Journal of the experimental analysis of behavior》2016,106(3):225-241
The baseline rate of a reinforced target response decreases with the availability of response‐independent sources of alternative reinforcement; however, resistance to disruption and relapse increases. Because many behavioral treatments for problem behavior include response‐dependent reinforcement of alternative behavior, the present study assessed whether response‐dependent alternative reinforcement also decreases baseline response rates but increases resistance to extinction and relapse. We reinforced target responding at equal rates across two components of a multiple schedule with pigeons. We compared resistance to extinction and relapse via reinstatement of (1) a target response trained concurrently with a reinforced alternative response in one component with (2) a target response trained either concurrently or in separate components from the alternative response across conditions. Target response rates trained alone in baseline were higher but resistance to extinction and relapse via reinstatement tests were greater after training concurrently with the alternative response. In another assessment, training target and alternative responding together, but separating them during extinction and reinstatement tests, produced equal resistance to extinction and relapse. Together, these findings are consistent with behavioral momentum theory—operant response–reinforcer relations determined baseline response rates but Pavlovian stimulus–reinforcer relations established during training determined resistance to extinction and relapse. These findings imply that reinforcing alternative behavior to treat problem behavior could initially reduce rates but increase persistence. 相似文献
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An integrated software package for testing infants in a habituation procedure is described. The software is written for an Apple II computer with a minimum of 64K of memory. Additional interface cards are required for timing responses and displaying dynamic stimuli. The software is divided into four independent modules: (1) Configure Experiment allows the experimenter to design a specific experiment. (2) Run Experiment controls the running of a previously configured habituation experiment. (3) Calculate Reliability allows a second observer to score the subject for the purpose of computing reliability. (4) Data Summary and Formatting provides a summary of the results and allows the user to flexibly format the data for reading by various statistical packages. 相似文献
120.
采用问卷法,以1488名大学生为被试,探讨了大学生神经质人格、手机网络服务使用偏好与手机网络过度使用行为的关系。结果表明：（1）大学生对手机网络服务的偏好依次是：信息服务、娱乐服务、社交服务和交易服务;（2）大学生神经质人格与手机网络服务偏好和手机网络过度使用有显著正相关,信息服务和娱乐服务与手机网络过度使用有显著正相关;（3）大学生神经质人格、信息服务和娱乐服务对手机网络过度使用具有直接正向预测作用;（4）神经质人格通过信息服务和娱乐服务间接影响大学生的手机网络过度使用,信息服务和娱乐服务在二者间起到部分中介作用。可以通过塑造大学生的积极人格,培养积极大学生的新媒体素养,有效抑制大学生对手机网络的过度使用行为。 相似文献