A critical discussion of Prior’s philosophical and tense-logical analysis of the ideas of indeterminism and human freedom

This paper is a critical discussion of A.N. Prior’s contribution to the modern understanding of indeterminism and human freedom of choice. Prior suggested that these ideas should be conceived in terms of his tense logic. It can be demonstrated that his approach provides an attractive formalization that makes it possible to discuss indeterminism and human freedom of choice in a very precise manner and in a broader metaphysical context. It is also argued that Prior’s development of this approach was closely linked to his very personal struggles with fundamental religious and metaphysical questions. In his opinion, holding the doctrine of divine foreknowledge together with the doctrine of human freewill gives rise to difficult logical and philosophical problems. It appears that Prior, rather early on, decided to support what was later known as the Peircean solution, although he also analysed what he considered to be the most important alternative solution—the Ockhamist solution. This paper offers a discussion of some of Prior’s published books and papers as well as some of the papers in his Nachlass.

     

How long does it last? Prior victimization from workplace bullying moderates the relationship between daily exposure to negative acts and subsequent depressed mood

The aim of the present study was to examine the relationships between daily exposure to negative acts and depressed mood on the same day and on the days following the exposure, and to test the hypothesis that these relationships would be stronger among those who have recently gone through a process of victimization from workplace bullying. The sample comprised 110 naval cadets participating in two different eleven-week tall ship voyages from Northern Europe to North America. Victimization from workplace bullying the last six months was measured one day prior to the voyages. Exposure to negative acts and depressed mood was measured daily during the first 33 consecutive days of the voyages. The results of multilevel modelling indicated that exposure to negative acts was related to higher levels of depressed mood on the same day as the exposure among all cadets, regardless of victimization status. However, exposure to negative acts predicted higher levels of depressed mood one and two days following the exposure among victims only. The theoretical and practical implications of these findings are discussed.     

Adolescent Suicide Attempters: What Predicts Future Suicidal Acts?

Predictors for repetition of suicide attempts were evaluated among 92 adolescent suicide attempters 9 years after an index suicide attempt (90% females). Five were dead, two by suicide. Thirty-one (42%) of 73 had repeated a suicide attempt. In multiple Cox regression analysis, four factors had an independent predictive effect: comorbid disorders, hopelessness, having ever received treatment for mental or behavior problems, and having a father exerting control without affection. Prediction on an individual level was difficult. Since almost half repeated a suicidal act, the best strategy is to evaluate all adolescent suicide attempters thoroughly and provide treatment as needed.     

Research misconduct among clinical trial staff

Between 1993 and 2002, 39 clinical trial staff were investigated for scientific misconduct by the Office of Research Integrity (ORI). Analysis of ORI case records reveals practices regarding workload, training and supervision that enable misconduct. Considering the potential effects on human subjects protection, quality and reliability of data, and the trustworthiness of the clinical research enterprise, regulations or guidance on use of clinical trial staff ought to be available. Current ORI regulations do not hold investigators or institutions responsible for supervision and training of clinical trial staff. Given the important issues at stake, the definition of research misconduct should encompass the intentional or negligent mismanagement of scientific projects. Individual institutions and professional associations not only can but should adopt stricter standards of conduct than those reflected in federal regulations.     

Performance under simulated offshore climate conditions

An experimental study was set up simulating the environmental conditions and work load among drillers and maintenance personnel offshore. Thirty-six male subjects participated in the experimental study involving 3h exposures with dry gloves, wet gloves or without gloves. The subjects were working on tasks involving heavy and light muscle work, dexterity and cognitive tasks. Body and skin temperatures and heart rate variability were continuously monitored. Neuropsychological and endocrinological parameters were intermittently monitored. The data from the work performance tasks showed that motor functions, both gross and fine, were impaired when working with wet and, especially, without gloves. Working without gloves also affected mental work tasks. The neuropsychological and physiological data confirmed the work task studies: working with wet or without gloves led to increased tremor and impaired finger dexterity. Furthermore, reasoning was consistently impaired throughout the exposures compared with working with dry gloves. The heart-rate variability data and the endocrine results also showed a significant central nervous stress reaction for the two hypothermic conditions compared with the dry glove condition. Especially for drilling further north these data should imply that both health and performance may be detrimentally affected during working under such conditions with insufficient thermal protection.     

Rod suppression of cone-mediated information about colour and form during dark adaptation

Following substantial bleaches, the specific form and hue thresholds were measured during dark adaptation with a test stimulus of 1 x 2 degrees at 40 degrees extrafoveally. The wavelength of the test field was varied between runs. The results show that both thresholds started to rise at about the cone-rod break of the dark-adaptation curve, irrespective of wavelength used in the test. Furthermore, the specific threshold for form was found to rise when a scotopic stimulus was superimposed on a photopic test flash. On the other hand, both thresholds remained at the cone-plateau level when the test flash was confined within the rod-free fovea. In order to explain the rise in the specific thresholds, it is suggested that signals from rods generated directly in response to the test stimulus may suppress both cone-mediated form and colour. It is also suggested that this type of rod-cone interaction represents a general characteristic involved in several kinds of visual information processing.     

Dark-adaptation mechanisms of the long-wave foveal cones

The ordinary long-term rod and cone dark-adaptation curves have generally been assumed to follow a single exponential rate of recovery. However, in two previous papers on rod dark-adaptation (Stabell et al., 1986a, b), the recovery curve was found to consist of three different sections. The results of the present paper show the same type of recovery function with three different sections for the long-term dark-adaptation curve of the long-wave cone system. During the major, middle section log cone threshold, like log rod threshold, is linearly related to the logarithm of the concentration of bleached photopigment. Presupposing that the bleached cone photopigment acts as a ligand, the change in threshold level obtained during the middle section of the dark-adaptation curve is well described by the change in activity rate of an allosteric, postively cooperative enzyme built as a dimer.     

EXPLAINING EMERGENCE: TOWARDS AN ONTOLOGY OF LEVELS

The vitalism/reductionism debate in the life sciences shows that the idea of emergence as something principally unexplainable will often be falsified by the development of science. Nevertheless, the concept of emergence keeps reappearing in various sciences, and cannot easily be dispensed with in an evolutionary world-view. We argue that what is needed is an ontological non reductionist theory of levels of reality which includes a concept of emergence, and which can support an evolutionary account of the origin of levels. Classical explication of emergence as “the creation of new properties” is discussed critically, and specific distinctions between various kinds of emergence is introduced for the purpose of developing an ontology of levels, framed in a materialistic and evolutionary perspective. A concept of the relation between levels as being inclusive is suggested, permitting the “local” existence of different ontologies. We identify, as a working hypothesis, four primary levels and explicate their nonhomomorphic interlevel relations. Explainability of emergence in relation to determinism and predictability is considered. Recent research in self-organizing non-linear dynamical systems represents a revival of the scientific study of emergence, and we argue that these recent developments can be seen as a step toward a final “devitalisation” of emergence.     

Long-term rod dark adaptation in man. Threshold measurements, rhodopsin regeneration and allosteric sensitivity regulation. An evaluation

Recent evidence strongly suggests that the relationship between threshold elevation ( T ) and fraction of bleached rhodopsin ( B ), obtained during a major, middle period of long-term rod dark adaptation in man, is well described by a power function, i. e., T = k · Bⁿ , where k is a multiplicative constant and n is the exponent. Due primarily to the low reliability of measurements of rhodopsin regeneration, however, the exponent n of the power function cannot, at present, be given an exact value. Available information indicates that the value of the exponent ranges between 2.4 and 4. Implications of this uncertainty are discussed within the framework of the allosteric, tetrameric model of rod dark adaptation. It is concluded that this model in its simplest form may only offer a first approximation of the real system implicated in the process.