Long-lasting effects of inescapable-predator stress on brain tryptophan metabolism and the behavior of juvenile mice

The kynurenine (KYN) pathway, which is initiated by indoleamine 2,3-dioxygenase, is the main tryptophan (TRP) metabolic pathway. It shares TRP with the serotonin (5-HT) pathway. We investigated the influence of inescapable-predator (rat) stress on behavior and brain TRP metabolism in mice. Male ICR mice (4W) were exposed to 20-min inescapable-predator stress. Behavior on an elevated plus-maze, and TRP, KYN, and 5-HT levels in the prefrontal cortex, hippocampus, amygdala, and dorsal raphe nuclei were measured 1 and 4 weeks after stress exposure. Predator stress increased the number of open-arm entries (NOA) 4 weeks after stress exposure without altering the number of closed-arm entries (NCA). Thus, the open/closed-arm entry ratio (NOA/NCA) increased after stress exposure. Predator stress increased KYN levels in the prefrontal cortex (until 4 weeks after stress exposure) and dorsal raphe nuclei (for 1 week after stress exposure), decreased 5-HT levels in all brain regions (until 4 weeks after stress exposure). Thus, predator stress increased the KYN/5-HT ratio in all regions, in particular in the prefrontal cortex and hippocampus until 4 weeks after stress exposure. Predator stress shifted the balance between the KYN and 5-HT pathways to the KYN pathway, and induced behavioral disinhibition.     

The association between infants' self-regulatory behavior and MAOA gene polymorphism

Self-regulatory behavior in early childhood is an important characteristic that has considerable implications for the development of adaptive and maladaptive functioning. The present study investigated the relations between a functional polymorphism in the upstream region of monoamine oxidase A gene (MAOA) and self-regulatory behavior in a sample of Chinese infants at 6 months of age. Self-regulation was assessed by observing infants' behavior of orienting visual attention away from a threatening event in the laboratory situation. The results indicated that regulatory behavior was associated with the functional MAOA gene polymorphism in girls, but not boys. Girls with 4/4 genotypes displayed significantly higher regulation than girls with 3/3 and 3/4 genotypes. The present study provided evidence for gender differences on the role of MAOA gene polymorphism in socioemotional functioning in the early years.     

关系研究的新取向：社会网络分析

社会网络分析（Social Network Analysis, SNA）是用社会实体之间的关系来描述、解释和预测社会现象的一种研究取向。SNA提供了深入探究社会环境特征及其对个体心理发展影响的一种方法。本文基于SNA的发展历程,依次介绍了中心性分析、小团体分析、位置分析、QAP以及统计模型法。SNA在社会学研究中得到了较多应用,近年来在心理学研究中开始受到重视。     

泰文和中文阅读过程中的眼动控制(中文)

This paper analyses some aspects of the eye movement behaviour of readers of Thai and Chinese. The main focus is on readers′landing site distributions on words and how these are affected by the lack of clear word boundary information due to the absence of inter-word spaces. Empirical evidence from Thai and Chinese readers suggest that readers can relatively accurately target word centres. We make the case that this accuracy can be accounted for by a default targetting model(effectively, the prior landing site distribution, in Bayesian terms)modulated by statistical cues about word beginnings available from word-initial character frequencies.     

薪酬差距:对公司盈余管理与经营绩效的影响

本文以我国993家上市公司为样本,对高管层的薪酬差距与公司盈余管理行为和公司绩效的相关性进行了实证检验.发现上市公司高管层薪酬差距的扩大,有利于减少高管层的盈余管理串谋,从而抑制为了提高薪酬而进行的盈余管理行为.同时,薪酬差距的加大会激励高管层更加努力地工作,体现在薪酬差距大的公司总资产收益率更高.这一结果印证了锦标赛理论,而组织公平理论所主张的薪酬差距的加大对组织内部合作的破坏等负面效应目前在我国上市公司中尚未产生显著的影响.     

中药在心血管疾病中应用现状与反思

具有悠久历史的中医药在现代医学中有鲜明的时代特点。心血管疾病是现代社会严重威胁生命及健康的病患。本文总结分析了古老中药在现代心血管疾病中应用的现状,并深入分析其影响因素,从而提出扬长避短的未来心血管疾病应用中药的思路。     

消化性溃疡的临床流行病学

消化性溃疡是消化系统常见多发病,20世纪在此领域有两个重要的发现,即有效的抑酸药质子泵抑制剂和幽门螺杆菌的发现,对其过去几十年的发病率和死亡率产生了巨大影响。尽管有了重大进展,这种疾病仍然是当前一个重要的临床问题,主要是因为越来越多的广泛使用非甾体抗炎药(NSAID)和低剂量阿司匹林药物。本文从流行病学角度来纵观其近年来的发病情况及其特点,以提供给同道参考。     

Hewitt多维完美主义量表在中学生群体中的修订

本研究以中学生群体为样本,对Hewitt多维完美主义量表(HMPS)进行修订。首先根据我国文化背景和青少年发展的具体状况建立了理论构想,接着对原量表进行了四次测查和检验修订,我们首先把指向他人和社会期望两个维度上的反向题改成正向题,并对所有项目的表述做了必要的修改;然后根据随后的测查结果进行了各维度和项目上的修改;最后删除了指向自我维度上的1个项目、指向他人维度上的2个项目和社会期望维度上的6个项目,修订后的HMPS量表的内部一致性信度α系数为0.91,指向自我、指向他人、社会期望的α系数分别为0.89,0.80,0.78,重测信度分别为0.80,0.79,0.67,与Frost多维完美主义量表中文修订版的相关分别为0.58,0.38,0.57。     

同性恋问题的道德探讨与法律应对

随着越来越多的国家就同性婚姻出台立法,同性恋已不单是道德问题,也带来了实践中的法律冲突。在这一背景下,应对同性恋问题进行道德上的理性思考,将接受同性恋与承认同性恋者的平等权利分开,并在谨慎处理我国是否为同性婚姻立法的同时,积极探讨如何应对涉外同性法律关系。