当今医学科技的发展趋势及我国的发展战略

作为生命科学最重要组成部分的医学科学走向科技发展的新时代。在下个世纪,科研重点将向生命科学和生命医学转移。充分认识医学科学技术的地位和作用,及当代医学科技发展的主要趋势和特点,制定我国医学科学的发展战略,加强医学高技术的发展,对我国的医学科技发展将具有十分重要的意义。     

Retroactive enhancement of a skin sensation by a delayed cortical stimulus in man: Evidence for delay of a conscious sensory experience

Sensation elicited by a skin stimulus (S) was subjectively reported to feel stronger when followed by a stimulus to somatosensory cerebral cortex (C), even when C was delayed by up to 400 ms or more. This expands the potentiality for retroactive effects beyond that previously known as backward masking. It also demonstrates that the content of a sensory experience can be altered by another cerebral input introduced after the sensory signal arrives at the cortex. The long effective S-C intervals support the thesis that a duration of cortical activity of up to 0.5 s is required before awareness of a sensory stimulus is developed.     

Enhancing attributional style and positive life events predict increased hopefulness among depressed psychiatric inpatients

A prospective study was conducted to investigate whether enhancing attributional style and positive life events are associated with recovery from depression through the mediation of increased hopefulness, as predicted by the Needles and Abramson (1990) model of recovery from depression. The Attributional Style Questionnaire, Beck Depression Inventory, Beck Hopelessness Scale, Dysfunctional Attitudes Scale, Uplifts Scale, and Revised Hassles Scale were administered to 32 depressed psychiatric inpatients shortly after admission and readministered a mean of 10 days later. The results indicated that the combined effects of enhancing attributional style and positive life events predicted decreases in hopelessness, which were in turn associated with decreases in depression symptom levels. By contrast, neither the combined effects of depressotypic attributional style and life events nor the combined effects of dysfunctional attitudes and life events was associated with decreases in hopelessness or depression symptom levels.     

Reducing work/home conflicts in employed couples: A proposed program to balance job and family demands

Work/home conflict is a dominant stress for workers in industrialized countries, particularly in dual-employment families. Interindividual (husband/wife) and interrole (work/home) conflicts in such families are a unique source of stress and adversely affect family and marital relationships as well as performance at work. Neither family therapy nor the stress literature have reported any interventions directed specifically at reducing work/home conflicts in employed couples or parents, although many workplaces today offer stress prevention programs aimed at individual workers. This paper discusses the underlying theoretical rationale for a marital enhancement intervention currently being developed for prevention of distress associated with work/home conflicts. The program combines marital enrichment and training principles with stress management techniques and aims at reinforcing shared coping resources. It focuses on four main variables associated with interpersonal processes: unrealistic expectations based on irrational beliefs, social undermining, shared decision control, and social support.     

Further lesion evidence for the neural basis of conceptual knowledge for persons and other concrete entities

The neural underpinnings of conceptual knowledge have been studied intensively, but many unanswered questions remain. In a previous study examining recognition of persons, animals, and tools in 116 participants with unilateral brain lesions, we found no instance of a patient who manifested defective recognition in all three categories. We reasoned that the spatial distribution of the lesion loci critical for the appearance of recognition defects for these different categories explained why this ‘three‐way’ defect could not be found in patients with unilateral lesions, and we proposed that only a suitable bilateral lesion would be likely to produce such a combined defect. In the study reported here, we tested this hypothesis by investigating recognition performances in 55 participants with bilateral cortical lesions. In support of the hypothesis, nine patients, all of whose lesions included bilateral occipitotemporal and/or temporal cortices, had a three‐way recognition impairment (persons, M=18.3%; animals, M=35.7%; tools, M=71.3%; all scores >2 SDs below normal). As expected, bilateral lesions to other neural sectors, for example prefrontal cortices, did not lead to recognition impairments. These findings provide further support for the notion that retrieval of knowledge for concrete entities from different conceptual categories depends on partially segregated neural systems, located in different sectors of occipitotemporal and temporal regions in right and left hemisphere.     

Improving Young Male Couples’ Sexual and Relationship Health in the 2GETHER Program: Intervention Techniques,Environments of Care,and Societal Considerations

Young male couples are at high risk for acquiring human immunodeficiency virus (HIV). However, few HIV prevention programs meet the needs of young male couples that express an interest in how to maintain healthy relationships. As such, we developed 2GETHER, a couple-based program that integrates HIV risk reduction and sexual health information into a relationship education program specific to young male couples. 2GETHER was guided by cognitive-behavioral theories of HIV risk reduction and relationship functioning and was informed by a social–ecological perspective to address factors within and outside the couple that can impact sexual and relationship health. As a micro-level intervention, 2GETHER intervenes directly with couples via psychoeducation and cognitive-behavioral strategies to change couples’ communication patterns, sexual health behaviors, and relationship satisfaction. Successful implementation of 2GETHER requires mezzo-level interventions that create an affirming environment of care for sexual minority individuals and facilitators who are culturally competent in working with young male couples. Although macro-level interventions to change societal acceptance of and policies germane to sexual minority couples are beyond the scope of 2GETHER, we discuss how clinicians can advocate for systemic changes to improve sexual minority couples’ health, and how 2GETHER addresses the impact of such macro-level factors on the couple’s relationship. Our experience developing and testing 2GETHER indicates that HIV prevention programs for young male couples should reflect the unique contexts shaping sexual minority individuals’ relationships and lives, and that programs should intervene within and across multiple levels when possible to improve health for sexual minority men.     

Attributional Ambiguity of Affirmative Action

We propose that affirmative action policies that are perceived to give preference to individuals solely or primarily on the basis of their group membership create attributional ambiguity about the personal deserving of individuals affected by these procedures. This ambiguity about the extent to which outcomes are deserved is hypothesized to be self-protective for people who are denied a position, but to have detrimental consequences among beneficiaries, especially if they are members of groups whose competence is doubted (either by themselves or others). Selection procedures that are perceived to be based both on individual merit and group membership, in contrast, are hypothesized to reduce attributional ambiguity about deserving and thus attenuate the effects of group-based preferential selection procedures on those who are benefited and bypassed by these procedures. An experiment was conducted to test these hypotheses. Men and women were randomly selected or rejected for a leadership role under one of three procedures: outcomes based (a) solely on sex, (b) solely on merit, or (c) on both sex and merit. Results provided partial support for our hypotheses.