Is phonological information mapped onto semantic information in a one-to-one manner?

Spoken word recognition models have to explain the influence of mismatching information on lexical activation. The effect of mismatching information is usually addressed with cross-modal semantic priming experiments using priming effects as a measure of the degree of lexical activation. Pseudowords phonologically related to a semantic associate of the target, e.g., *domato-PAPRIKA, serve as primes. Mismatch effects at the word form level are supposed to percolate unaltered to the semantic level. We show that cross-modal semantic priming might underestimate activation at the word form level. Targets (e.g., PAPRIKA) were preceded by either phonologically related pseudoword primes (e.g., *baprika) or semantically related pseudoword primes (e.g., *domato). Different priming and RT patterns were obtained for the two priming relations.     

Prognostic relevance of quantitative topographical EEG in patients with poststroke aphasia

In this prospective study we analyzed the prognostic value of topographical quantitative EEG (qEEG) in poststroke aphasia. Twenty-three right-handed patients (ages 56 +/- 12 years) with different types of aphasia were studied. Quantitative EEG under resting conditions and an aphasia test battery were applied twice, 2 and 8 weeks after a stroke. EEG power fast Fourier transform was performed for delta (2-3.5 Hz), theta (4-7.5 Hz), alpha (8-13 Hz), and beta (13.5-20 Hz) frequency bands. EEG abnormalities within and outside speech relevant areas are related to restitution of poststroke aphasia. In the ischemic regions they indicate local disturbances; outside they reflect failures in neuronal networks involved in the generation and propagation of the alpha rhythm.     

Patterns of neuropsychological performance in multiple system atrophy compared to sporadic and hereditary olivopontocerebellar atrophy

Although neuropsychological symptoms are associated with multiple system atrophy (MSA), sporadic olivopontocerebellar atrophy (sOPCA), and dominantly inherited olivopontocerebellar atrophy (dOPCA), the differences between these groups have not been explored. We compared 28 MSA patients on psychiatric rating scales and neuropsychological measures to 67 sOPCA patients, 42 dOPCA patients, and 30 normal controls. Patients with dOPCA, sOPCA, and MSA all exhibited significant deficits on motor-related tasks, as well as relatively mild deficits in cognitive functioning. Patients with MSA had greater neuropsychological dysfunction, particularly in memory and other "higher order" cognitive processes, than patients with either sOPCA or dOPCA.     

Semantic generation can cause episodic forgetting

The repeated retrieval of a subset of previously learned items can cause forgetting of the nonretrieved items. The study reported here investigated whether retrieval-induced forgetting generalizes to a situation in which the retrieved and nonretrieved items are not part of the same experiential episode and task. Subjects learned an item list that they had to recall later in the experiment. In a separate intermediate phase, they repeatedly generated related items from semantic memory, or were presented the same items intact for study. Only the semantic generation of items, and not their presentation for study, induced forgetting of the initially learned items. This result indicates that, first, semantic generation can cause recall-specific episodic forgetting and, second, retrieval-induced forgetting can occur even if the retrieved and nonretrieved items belong to different experiential episodes and tasks. Connections of the present results to other memory phenomena, such as part-set cuing and the generation effect, social cognition, and eyewitness memory, are discussed.     

Why misinformation is more likely to be recognised over time: A source monitoring account

Although memory for actual events tends to be forgotten over time, memory for misinformation tends to be retrieved at a stable rate over long delays or at a rate greater than that found immediately after encoding. To examine whether source monitoring errors contribute to this phenomenon, two experiments investigated subjects' memory for the source of misinformation at different retention intervals. Subjects viewed a slide presentation, read a narrative containing misinformation, and, either 10 minutes or 1 week later, completed a recognition test about details seen in the slides and about the source of these details. After the longer retention interval in both experiments, participants were more likely to agree that they had seen misleading information and were also more likely to incorrectly associate the misinformation with the slide event. Theoretical implications of these findings are considered.     

Pharmacogenetics: ethical issues and policy options

Pharmacogenetics offers the prospect of an era of safer and more effective drugs, as well as more individualized use of drug therapies. Before the benefits of pharmacogenetics can be realized, the ethical issues that arise in research and clinical application of pharmacogenetic technologies must be addressed. The ethical issues raised by pharmacogenetics can be addressed under six headings: (1) regulatory oversight, (2) confidentiality and privacy, (3) informed consent, (4) availability of drugs, (5) access, and (6) clinicians' changing responsibilities in the era of pharmacogenetic medicine. We analyze each of these categories of ethical issues and provide policy approaches for addressing them.     

A neural correlate of consciousness related to repression

In previous research Libet (1966) discovered that a critical time period for neural activation is necessary in order for a stimulus to become conscious. This necessary time period varies from subject to subject. In this current study, six subjects for whom the time for neural activation of consciousness had been previously determined were administered a battery of psychological tests on the basis of which ratings were made of degree of repressiveness. As hypothesized, repressive subjects had a longer critical time period for neural activation of consciousness, suggesting the possibility that this neurophysiological time factor is a necessary condition for the development of repression.