PSYCHOPHYSIOLOGICAL REACTIONS TO TWO DIFFERENT PLACEBO TREATMENTS

Reactions to a placebo introduced either as a depressant or as a stimulant drug were examined in 16 healthy female subjects. Comparisons between pre- and post-placebo measurements showed that the two treatments produced marked effects in opposite directions: (1) the 'depressant' placebo produced a statistically significant decrease in pulse rate, blood pressure, objective and subjective reaction speed, as well as significant effects on subjective mood in the expected directions, and (2) the 'stimulant' placebo produced opposite and significant changes in all variables. The subjective reactions were, on the whole, more pronounced than the effects on performance and physiological functions.     

Effects of pentobarbital on fixed-ratio reinforcement,

Certain doses of pentobarbital consistently increased the rate of pecking engendered by a fixed-ratio schedule of 30 responses in a group of 13 pigeons, and still higher doses produced decrements in rate of responding. For individual subjects, the dose-effect functions were qualitatively similar, but differed with respect to the doses producing the maximum increase and subsequent decrease in rate. In general, the maximum occurred at lower doses and the decrement was greater at the highest dose in the birds with the highest control rates. It was also possible to distinguish between the effects of pentobarbital and several other drugs on the behavior maintained by FR 30. The results indicate that changes in rate of responding on FR 30 after drug administration are dose-dependent, drug-specific effects.     

The effects of unavoidable shocks on a multiple schedule having an avoidance component

Two dogs were maintained on a multiple schedule having both a food reinforced and an avoidance component (Mult VI 1′ S^Δ Avoid_{SS20 RS20} S^Δ). The effects of superimposing an Estes-Skinner procedure for delivering unavoidable shocks on all components of the multiple schedule were observed. The buzzer-shock pairing of the Estes-Skinner procedure produced an increased rate of responding on the avoidance component of the schedule and also on the S^Δ components. No persistent change in rate was observed on the food component during the pre-shock stimulus. Control performances on all components could be regained by either extinguishing or eliminating the buzzer-shock pairing. Extinction of the avoidance responding had little effect on the increased rates of responding produced by the Estes-Skinner procedure on the S^Δ and avoidance extinction components and did not lead to a conditioned suppression of the food reinforced responding. Rate of responding during the pre-shock stimulus was observed to be relatively independent of changes in the maintaining schedules. Responding during the pre-shock stimulus could be conditioned and maintained after an extensive history of avoidance extinction.     

Generalization gradients of inhibition following auditory discrimination learning

A more direct method than the usual ones for obtaining inhibitory gradients requires that the dimension of the nonreinforced stimulus selected for testing be orthogonal to the dimensions of the reinforced stimulus. In that case, the test points along the inhibitory gradient are equally distant from the reinforced stimulus. An attempt was made to realize this condition by obtaining inhibitory gradients along the frequency dimension of a pure tone after discrimination training in which the nonreinforced stimulus was a pure tone (or tones), and the reinforced stimulus was either white noise or the absence of a tone. The results showed that some degree of specific inhibitory control was exerted by the frequency of the tone, although the gradients were broad and shallow in slope.

A further experiment was conducted to see whether the modification of an excitatory gradient resulting from training to discriminate neighboring tones could arise from a simple interaction of inhibitory and excitatory gradients. The results indicated that it could not, since discrimination training produced a concentration of responding in the vicinity of the reinforced stimulus which cannot be derived from any plausible gradient of inhibition.

     

Schedules using noxious stimuli. II: low intensity electric shock as a discriminative stimulus

The presence or absence of pulses of low intensity electric shock was used as a discriminative stimulus to control responding under fixed ratio reinforcement in the squirrel monkey. Initially brief periods of nonreinforcement were lengthened only when discriminative control was evident. Discriminative control was studied by (1) varying the duration of nonreinforcement periods; (2) reversing the stimulus conditions correlated with reinforcement and nonreinforcement periods; and (3) determining the minimum shock intensity necessary to maintain discriminative control. Stimulus control was not reliably affected by d-amphetamine, chlorpromazine, or morphine. The discriminative control by pulses of low intensity electric shock was similar to that by other discriminative stimuli, except that the control developed slowly and was better when the pulsing shock was correlated with reinforcement than when correlated with nonreinforcement.