Independence of uniphasic and biphasic audiogenic seizure progressions in mice

DBA/2J mice were monaurally or binaurally tested for susceptibility to sound-induced seizure. Two seconds following the beginning of running, one group of binaurally tested mice had acoustic stimulation interrupted for 15 s. These mice later seized when the stimulation was readministered. Their seizure progression closely resembled the behavior exhibited by noninterrupted binaurally stimulated mice and did not shift to the biphasic motor pattern of monaurally stimulated subjects. We conclude that the single burst of running of a binaurally tested mouse is qualitatively different from either of the two bursts of running exhibited by monaurally tested mice.     

Attenuation of amphetamine-stereotypy by mesostriatal dopamine depletion enhances plasma corticosterone: implications for stereotypy as a coping response

The relationship between amphetamine-induced stereotyped behavior and a neuroendocrine index of arousal, plasma corticosterone (CCS), was investigated. 6-Hydroxydopamine lesions of the caudate-putamen, which produced dopamine depletions of 60%, blocked stereotypy and prolonged the elevation in corticosterone associated with d-amphetamine treatment (5 mg/kg). Similar dopamine depleting lesions of the nucleus accumbens, which attenuated the locomotor, but not the stereotypic, response to AMPH did not have this effect on CCS. This pattern of results supports the hypothesis that stereotypy has a coping function which may serve to alter arousal and further suggests important differences between the nigrostriatal and mesolimbic dopamine projections in modulating the responsiveness of the neuroendocrine system. These results have implications for understanding the function of behavioral stereotypies common to a number of psychopathological conditions, including schizophrenia and childhood autism.     

Synaptic plasticity in the hypoglossal nucleus of female canaries: structural correlates of season, hemisphere, and testosterone treatment

The caudal portion of the hypoglossal nucleus (nXIIts) contains the motor neurons that control the syrinx in songbirds. In canaries, song occurs seasonally, is principally produced by males, and appears to be produced predominantly by muscles on the left side of the syrinx. The present study measures the effect of seasonal change and manipulation of testosterone levels on synapse number and morphology in nXIIts in adult female canaries. We find that synapse density is lower in testosterone-treated birds than in control birds and lower in fall than in spring. The number of vesicles per presynaptic profile increases in the spring as a result of a general increase in this measure in all synapses. The number of vesicles per presynaptic profile also increases with testosterone treatment, primarily due to an increase in the proportion of synapses associated with unusually high vesicle counts. Together, these changes suggest that large reserves of neurotransmitter may be necessary to sustain singing. Several ultrastructural differences between hemispheres are found. Postsynaptic thickenings are longer, and postsynaptic processes are larger on the left side than on the right side. In the spring, there are more vesicles per synapse on the left than on the right, but this lateralization is reversed in the fall. Thus, lateralization of song production is associated with lateral asymmetries in synapse morphology. These hemispheric differences are relatively small, like those seen at the light microscope level, encouraging further consideration of peripheral as well as CNS sources of functional lateralization. The seasonal and testosterone-induced changes in synapse number and morphology may be components of the periodic reorganization of canary vocalization.     

Visual gap and offset discrimination and its relation to categorical identification in brief line-element displays

Visual processing was investigated in judgments of relative line position. Stimulus continua were generated by bisecting a straight line and displacing the segments. Experiment 1 measured discrimination of pairs of longitudinally displaced segments at equal steps along the continuum. At long (2 s) durations discrimination fell smoothly, but at short (100 ms) durations it was sharp-peaked. In Experiment 2 the short-duration stimuli were labeled with subsets of the labels no gap, just a gap, and more than just a gap. Theoretical discrimination performances were computed and the one based on no gap and just a gap closely fitted observed performance. Experiments 3 and 4 were similar to 1 and 2, with lateral replacing longitudinal displacement. Similar "categorical" performance was obtained. It was concluded that there are discrete mechanisms for early detection of relative line position and that 2 labels can be used to characterize performance in each direction.     

The effect of response bias on recall performance, with some observations on processing bias

We explored Roediger and Payne's proposal that response bias does not affect recall performance and that it is therefore not necessary to control for response productivity in recall studies. Two initial experiments, contrary to expectation, corroborated Roediger and Payne's findings: Forced recall did not produce more correct recalls than free recall, even though forced recall produced substantially more false alarms than did free recall. However, in succeeding experiments involving pictorial and verbal stimuli, reliable response-bias effects on recall were demonstrated. The stimuli yielding response-bias effects were those associated with higher probabilities of being guessed by chance. In addition, some of the data suggest that processing-bias effects (differential retrieval effort) may be unintentionally induced by instructions and may significantly affect recall memory. Consequently, it is necessary to assess or to control response-bias effects and, possibly, processing-bias effects in recall experiments in which level of recall is of interest.     

Hemispheric preference and progressive-part or whole practice in beginning typewriting

This investigation explored the interaction of progressive-part versus whole methods of practice with hemispheric preference for processing information and the impact of each upon high school students' speed and accuracy in beginning typewriting. Zenhausern's Differential Hemispheric Activation Test was scored in such a way that it was possible to plot the scores along a continuum. Analysis of variance gave significant F ratios on 3 of the 4 testing days. The continuous scores were divided into five categories: middle, left moderates, right moderates, extreme rights, and extreme lefts. The moderate-left group speed was consistently the fastest group, and the extreme rights were consistently the slowest group. This difference was significant for all four testing days with the moderate-left mean speed varying between 4 to 6 words per minute faster each testing day. The extreme rights were consistently the most accurate, even though not statistically significantly so. There was no significant difference between method of practice and typewriting speed or between method of practice and typewriting accuracy; however, on all four testing days the mean gross speed of the whole practice learning group was 0.73 to 0.99 words per minute faster than the progressive-part group. A two-way analysis of variance indicated no interaction between method or practice and hemispheric preference.     

Aversiveness of denatonium saccharide and quinine in grasshopper mice Onychomys leukogaster

The responses toward denatonium saccharide and quinine by three rodent species differ from those exhibited by humans. This study measured the relative aversiveness of these two compounds in grasshopper mice (Onychomys leucogaster) to determine if this species responded similarly to or differently from these other rodents. In a choice test, the mice clearly preferred quinine over denatonium saccharide at concentrations of 1/10,000 and 1/50,000, but only marginally preferred quinine at a concentration of 1/1000. When denatonium or quinine was paired with toxicosis, both suppressed drinking at concentrations from 1/10,000 to 1/50,000, but only denatonium suppressed drinking at 1/100,000. Neither compound suppressed drinking at 1 part in million. Grasshopper mice perceived denatonium saccharide as more aversive than quinine in both experiments. Such a response resembled the behavior of humans more than that of the other three rodents previously tested.     

Psychologists and alcoholic women

Alcoholism among women often has been treated using a model based on research with alcoholic men. Women react differently to alcohol than men both physiologically and psychologically and their drinking patterns are different from men's. Treatment facilities for alcoholism have not been as available for women as for men and treatment must be individualized for the differences between men and women problem drinkers and for the differences among alcoholic women.     

Length of survival and lymphocyte percentage in women with mammary cancer as a function of psychotherapy

50 patients suffering from terminal mammary cancer and visceral metastases received chemotherapy, and in addition half of them received psychotherapy, while half did not. A lymphocyte count was undertaken seven times in all, once before initiation of chemotherapy, the others after six applications of the therapy. As hypothesized, the 25 women who received psychotherapy lived longer and had significantly higher lymphocyte counts on Occasions 5, 6 and 7 than did the 25 women who did not receive psychotherapy. Of the types of psychotherapy employed, a specially designed form of behaviour therapy was significantly more helpful than dynamic psychotherapy in prolonging life.