Impact of Institutional Review Boards on cancer research

The concepts of informed consent and surveillance of human research designed to protect human subjects is commendable. The regulations of the Institutional Review Board (IRB) are having a major impact on clinical cancer research. There is greater administrative time needed of the investigator, the mechanisms of patient care have become cumbersome and some patients reject optional medical management that could be life saving. IRB regulations must be flexible to meet the needs of human subjects as well as those of the clinical investigator.     

An analysis of some sensitizing agents in the pathogenesis of stress-induced gastric erosive disease

Prior surgical implantation of a venous catheter sensitized rats to coldimmobilization stress. Three of six catheterized females succumbed during the stress. The remaining rats fell into two groups in terms of their core temperature at the end of the stress period: Male uncatheterized rats had higher temperatures than rats in the other three groups. No relation was found between catheter patency and magnitude of hypothermia. Degree of gastric disease paralleled the core temperature findings in that the male uncatheterized rats had significantly fewer gastric erosions than the rats in the other three groups. Additionally, a robust effect of gender was found with uncatheterized females showing more hypothermia and more gastric disease than uncatheterized males. A subsequent experiment was conducted to evaluate whether anesthesia or wearing the protective spring was responsible in part for the sensitization seen. Here, the gender difference was less although females consistently averaged lower core temperatures after stress than did males. Despite similar core temperatures after stress, females that were prepared with the protective spring apparatus developed more gastric disease than female controls or similarly treated males. Thus, the additional sensitization exhibited by females in the first experiment may relate to the fact that both catheterization and the taping procedure were sensitizers while only catheterization was a sensitizer for males.     

Frames of reference in preschoolers’ perception of motion

Experiments 1 and 2 established children’s (mean age 3 years, 7 months) subject-relative and object-relative motion thresholds at 1°31.37′/sec and 1°9.33′/sec, respectively, speeds well above those found for adults. Experiment 3 established that preschoolers, like adults, attribute object-relative motion to the smaller of two objects, with the inducing properties of the larger stimulus greatest when it is surrounding rather than adjacent to a smaller stimulus. The inducing advantage of surroundedness was equivalent for a single-element square frame and a multielement six-dot frame.     

The emerging role of school psychology

This report relates personal experiences as they influenced the emerging role of the school psychologist, especially in Pennsylvania and Indiana from 1930 to 1970.     

Factor analysis of the Wechsler adult intelligence scale-revised (WAIS-R): An examination of the standardization sample

Orthogonal and oblique factor analyses were performed using the Wechsler Adult Intelligence Scale-Revised (WAIS-R) standardization sample (Wechsler, 1981). Using objective criteria, it was decided to retain two factors. Evidence for a strong general intelligence (g) factor was found from both the orthogonal and oblique rotations. Whereas the verbal IQ provided an acceptable estimate of the Verbal Comprehension factor, a purer measure was found in the form of a Verbal Comprehension Deviation Quotient containing only the Information, Vocabulary, Comprehension, and Similarities subtests. The performance IQ was found to be an inadequate measure of the Perceptual Organization factor. A Perceptual Organization Deviation Quotient, containing only the Block Design and Object Assembly subtests, was recommended as an effective alternative. Analysis of the variance components for each subtest at every age level revealed that a substantial proportion of subtests at a wide range of age levels evidence either high or intermediate levels of specific variance. These results are discussed in terms of interpreting individual subtest scores and patterns. Each of the study's major findings are compared with prior work done with the Wechsler Adult Intelligence Scale (WAIS) (Wechsler, 1955).     

Generalization of treatment effects in training public speakers

Three studies compared the efficacy of various treatments for public-speaking incompetence. These effects were evaluated for the target behavior as well as for generalization effects across situations (conversations), settings (different sizes and types of audiences) and time (6-month follow-up). The first study showed that Self-instructional Training, either alone or in combination with other procedures, produced little or no benefits. The second study demonstrated the superiority of a Skills Training program over flooding therapy, while the final study failed to detect any enhancement of treatment benefits for the addition of home-practice to the Skills Training. In the first two studies generalization occurred across the three dimensions (settings, situations and time), while in the final study it was shown that the program was effective for a clinical population as well as recruited volunteers.