A neural basis for the development of inhibitory control

The present study explores the neural basis of the development of inhibitory control by combining functional neuroimaging with a parametric manipulation of a go–nogo paradigm. We demonstrate how the maturation of ventral fronto–striatal circuitry underlies the development of this ability. We used event–related fMRI to examine the effect of interference on neural processes involved in inhibitory control in children and adults. Nogo trials were preceded by either 1, 3 or 5 go trials and then compared to one another. Both children and adults showed an increase in errors with increasing interference. Successful response inhibition was associated with stronger activation of prefrontal and parietal regions for children than for adults. In adults, activation in ventralprefrontal regions increased with increasing interference from go trials. Unlike adults, the circuitry appeared to be maximally activated in children when suppressing a behavioral response regardless of the number of preceding responses. Furthermore, activation in ventral fronto–striatal regions correlated with both age and performance. These findings suggest that immature cognition is more susceptible to interference and this is paralleled by maturational differences in underlying fronto–striatal circuitry.     

An exploratory study of the facets of Type A personality and scores on the Machiavellian Behavior (MACH-B) Scale

The relationship of two facets of Type A personality, Achievement Striving and Impatience-Irritability, with Mach-B scores was investigated. Mach-B scores were not correlated with Achievement Striving and were positively correlated (r = .37; p < .01) with Impatience-Irritability in a sample of 51 hospital employees including physicians (n = 12), nurses (n = 12), administrative staff (n = 13), and custodial services employees (n = 14).     

Socio-cultural features and sex profile of the individuals with serious suicide attempts in southeastern Turkey: a one-year survey

Our objective was to elucidate potential causes of higher rates of suicide attempts in females compared to males in southeastern Turkey through a 1-year survey. Gender-related differences observed in 96 subjects who attempted suicide by poisoning for the first time were as follows: in comparison to male, females were predominantly within the age interval of 15-24 years, experienced more stressful events in the previous week before suicide attempt, had lower education level, and had a lower rate of employment. One year after the suicide attempt, unfavorable attitude of family, lack of support, persisting unfavorable lifestyle comparable with that prior to the first attempt, and higher rates of domestic violence were more pronounced in females compared to males. These findings might be contributing factors to the higher suicide attempt rates observed in females compared to the males.     

Female Suicide Rates in Ghizer,Pakistan

Suicide is an understudied subject in Pakistan. There are many social, legal, and religious sanctions against it. National rates of suicides are not known. We calculated suicide rates of women in the Ghizer District of the remote Northern Areas of Pakistan. During years 2000 to 2004, 49 women committed suicide. Taking average mean population for women for 5 years as 65,783, we calculated annual crude suicide rates for women as 14.89/100,000/year. For women over the age of 15 years, rates were 33.22/100,000/year; age‐specific rates for 15–24 years were 61.07/100,000 per year. These figures are considerably higher than suicide rates in other parts of Pakistan and may be related to high psychiatric morbidity in Pakistani women. This study underscores the need for a standardized system of registration of suicides in Pakistan. There is also urgent need to address high psychological distress in women in Pakistan.     

Monitoring brain development with quantitative diffusion tensor imaging

Quantifying changes that occur during brain maturation may help in diagnosing diseases that affect pediatric patients. By obtaining normative curves that define brain maturation, pathological changes may be easier to recognize. We assessed diffusion changes which are inherently related to the brain structure during maturation and obtained normative curves. MR scans were obtained for 26 pediatric subjects (ages 0 to 11 years) and four adults. The MR images were all normal. Maps of the average diffusion constant (D_av) were calculated for each subject. Changes in D_av were determined with distribution analysis for the entire brain and compared with regions of interest measurements from the periventricular white matter and thalamus. The mean diffusion constant of the whole brain changes quite rapidly as the brain matures. The data suggest that at least two distinct processes are responsible for the change. Quantitative diffusion tensor imaging may provide means of quantifying overall human brain maturation that may be useful in diagnosing pathology.     

The Moderating Role of Social Support Between Role Stressors and Job Attitudes Among Roman Catholic Priests1

This study examined the relations role stressors and job attitudinal variables, as well as the potential moderating effects of social support in a sample of 190 Roman Catholic priests. The priesthood is an important occupation to study because the work priests do can be considered a vocation instead of a job. Role stressors were negatively correlated with job attitudes (e.g., job satisfaction, turnover intention). Consistent with a buffering hypothesis, several sources of social support (parishioners, staff, fellow priests) consistently moderated this relationship, in that the relationship attenuated as social support increased. The implications of these results are discussed with respect to the role of the priest, as well as with other types of work‐based vocations.     

Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: Evidence of a compensatory mechanism

Brain-derived neurotrophic factor (BDNF) plays a regulatory role in neuronal differentiation and synaptic plasticity and has been linked to glucose regulation and cognition. Associations among plasma BDNF, cognition, and insulin function were explored. Forty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ. Participants received complete medical, neurological, psychiatric, and neuropsychological evaluations. IIF individuals had significantly lower plasma BDNF levels than controls, particularly females, and higher BDNF levels were associated with poorer explicit memory in IIF females, suggesting that higher levels within this group may reflect the body’s efforts to respond to damage. After accounting for age, education, and HbA1c, BDNF significantly predicted 13.1–23.5% of the variance in explicit memory in IIF women. These findings suggest that BDNF elevations within diseased groups may not always be a marker of health.     

Family interactions and the course of schizophrenia in African American and White patients

Relatives' critical and intrusive behavior with patients, patients' odd or unusual thinking with relatives, and the course of schizophrenia were examined. Seventy-one African American and White patients (each with 1 relative) completed 2 problem-solving discussions. Relatives' critical and intrusive behavior with patients and patients' odd or unusual thinking with relatives were assessed, and patients were followed for 2 years. For African American patients, high levels of relatives' critical and intrusive behavior were associated with better outcome. For White patients, low levels of both relatives' critical and intrusive behavior and patients' odd or unusual thinking with relatives were associated with better outcome. The results suggest that during family interactions, seemingly negative behaviors may be perceived as a sign of caring and concern by African Americans. For Whites, the combination of patients' odd or unusual thinking with relatives and relatives' critical and intrusive behavior toward patients may be especially predictive of an adverse course.