Alternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat

The effects of dopaminergic depletion of the nucleus accumbens was tested in various behavioral tasks such as alternation, spatial discrimination, and reversal learning, and in an extinction paradigm in a T maze. Animals with lesions showed impairment of spontaneous alternation behavior, disturbances in the acquisition of spatial discrimination, and great difficulty in reversing previously learned habits. In the extinction phase, experimental animals are unable to adjust their behavior, and continue to choose the previously reinforced arm of the T maze. It is suggested that the nucleus accumbens plays an important role in the transition of motivation into action, and that dopamine has a facilitatory influence on the mediation of these processes.     

Little oscillation of daily food intake in mousekiller rats as opposed to nonkiller rats before any confrontation with mice

During 46 consecutive days the daily food intake and weight were recorded in 16 male Wistar rats. On Days 31-45 one mouse was presented each rat daily. Before any experience with mice (Days 0-27) the mousekiller rats, compared with the nonkiller rats, regulated their individual food intake more closely to their homeostatic equilibria, corrected for the linear trend. This result indicates a functional difference in food intake regulation between mousekiller rats and nonkiller rats prior to any experience with mice. However, no difference in the mean food intake was found between the mousekiller and the nonkiller rats.     

Aggressive behavior inhibition by serotonin and quipazine injected into the amygdala in the rat

The effects on aggressive behavior, open-field activity, and pain threshold of bilateral microinjections of serotonin (20 micrograms) and quipazine (20 micrograms), the direct serotonergic receptor agonist, into the cortico-medial amygdala were investigated in Wistar rats. Both drugs significantly prolonged the attack latency in isolated killer rats (predatory aggression model), and suppressed the incidence of aggressive postures/attacks in shock-induced fighting test (affective aggression). The only difference in the open-field behavior was the lower number of central square entries in drug-treated compared to saline-injected rats. None of the substances produced any significant change in jump threshold. It is concluded that stimulation of serotonin receptors within the amygdala produces inhibition of affective and muricidal behavior in isolated rats. The effect does not seem to be dependent on changes in general activity and pain sensitivity.     

A paradoxical prediction from locus of control

Individual differences in attribution have been little researched. Beliefs about locus of control have been taken to be stable and important differences between people. They may provide some of the background assumptions on which people base their explanations of actions, especially insofar as these explanations imply that the cause of an action was within the agent or his environment, and that the action was or was not under the agent's control. Respondents were therefore asked to fill in Rotter and Levenson locus of control questionnaires and to provide explanations or ask questions about several actions. It was hypothesized that internals would be inclined to go for explanations which were personal and implied high control, while externals would not. However, what emerged was the paradoxical finding that internals provided explanations which implied that the causes of the actions lay outside the agent, while externals provided ones which implied that the causes lay within. This result is discussed in terms of the difference between actions and outcomes, and the possibility that an important difference between people may be in the rigidity and simplicity of their beliefs about causality.     

The negative priming effect: Inhibitory priming by ignored objects

A priming paradigm was employed to investigate the processing of an ignored object during selection of an attended object. Two issues were investigated: the level of internal representation achieved for the ignored object, and the subsequent fate of this representation. In Experiment 1 a prime display containing two superimposed objects was briefly presented. One second later a probe display was presented containing an object to be named. If the ignored object in the prime display was the same as the subsequent probe, naming latencies were impaired. This effect is termed negative priming. It suggests that internal representations of the ignored object may become associated with inhibition during selection. Thus, selection of a subsequent probe object requiring these inhibited representations is delayed. Experiment 2 replicated the negative priming effect with a shorter inter-stimulus interval. Experiment 3 examined the priming effects of both the ignored and the selected objects. The effect of both identity repetition and a categorical relationship between prime and probe stimuli were investigated. The data showed that for a stimulus selected from the prime display, naming of the same object in the probe display was facilitated. When the same stimulus was ignored in the prime display, however, naming of it in the probe display was again impaired (negative priming). That negative priming was also demonstrated with categorically related objects suggests that ignored objects achieve categorical levels of representation, and that the inhibition may be at this level.     

Selective attention and priming: Inhibitory and facilitatory effects of ignored primes

The priming effects of ignored information have been studied in Stroop displays (Neill, 1977) and with spatially superimposed drawings (Tipper, in this issue); naming of probes related to ignored primes is delayed in these experiments (“negative priming”). This negative priming effect is confirmed in a list reading task in Experiment 1, which used partially superimposed letters, and Experiment 2, which used spatially separated letters. Furthermore, Lowe (1979) using Stroop colour words observed that changing the nature of the probe such that it did not require selection from a competing word reversed the priming effects of the ignored word from inhibition to facilitation. Experiment 3 confirmed this observation when subjects selected a red letter from a green letter. Two models are suggested to account for this result. In the first, negative priming is a product of the ignored prime and subsequent probe being encoded both as a stimulus to be ignored and one to be named (Allport, Tipper and Chmiel, in press; Lowe, in press). This dual encoding is ambiguous, requiring further processing before response can be output. The other model suggests that negative priming reflects inhibition of response to ignored information, slowing naming latencies to probe stimuli that require the same response. Experiment 4 attempts to differentiate between the models, and the latter inhibition view is preferred.     

The pathological left-handedness syndrome

A clinical syndrome of pathological left-handedness (PLH) is proposed to identify the pattern of correlative changes in lateral development associated with early brain injury in some manifest left-handers. This syndrome is believed to be caused by a hemispheric lesion that is predominantly left-sided (or bilateral asymmetric), which onsets before Age 6, and which encroaches upon the critical speech zones of the frontotemporal/frontoparietal cortex. The pattern of changes may include any or all of the following features: shifts in manual dominance, trophic changes in the extremities, transfer of hemispheric speech, and/or intrahemispheric reorganization of visuospatial cognitive functions. Although some of these correlates of PLH have long been known, they have not been recognized as an interrelated pattern of traits that constitute a clinical syndrome. Identification of these individuals, all manifest left-handers, will be shown to have implications for diagnosis/remediation and for models of recovery of function.     

Seeking urgent pediatric treatment: factors contributing to frequency, delay, and appropriateness

The present study explored the factors that contribute to mothers' decisions to seek urgent medical attention for their children when symptoms are not of a traumatic nature. One hundred mothers seeking treatment for their children at a prepaid clinic completed a questionnaire eliciting their expectations regarding the course of their children's problems, seriousness of the problems, perceived responsibility for the symptoms, and extent to which a variety of factors contributed to their decisions to seek treatment. Demographic data and information about each child's symptoms and medical history were also obtained. Four major "reasons for seeking treatment" factors were identified: family history of the presenting complaint, worry regarding the symptoms, situational variables, and the extent of the child's illness behavior. The appropriateness of the visit, delay in seeking treatment, and frequency of mothers' use of the pediatric clinic were predicted by the nature of the presenting symptoms (particularly the presence of fever), the ages of the mother and child, and two of the reasons for seeking treatment factors (i.e., family history and child's illness behavior). The present study suggests that mothers pay more attention to presenting symptoms and to the children's behavior than to psychosocial stressors in deciding to seek urgent care.     

Selective cardiovascular effects of stress and cigarette smoking in young women

In an earlier study, we found that men who smoked a cigarette and then engaged in a mildly stressful activity (video game) evidenced pronounced increases in heart rate and blood pressure, which were approximately equal to the sum of the effects produced by either smoking alone or stress alone. In the present study, a 2 (smoke vs. sham smoke) X 2 (stress vs. no stress) factorial design was used to evaluate the impact of stress and smoking on the cardiovascular responses of young women. The results revealed that the combination of stress and cigarette smoking produced blood pressure and heart rate responses that were larger than the additive effects of smoking and stress taken separately.     

Co-occurrent use of cigarettes, alcohol, and coffee in healthy, community-living men and women

Previous studies have examined intra-individual aggregation in the use of cigarettes, alcohol, and coffee by examining the co-occurrent use of any pair of these three substances. A recent literature review failed to find a single investigation that studied use of all three in the same sample. In the present study, co-occurrent use of all three of these substances was examined in crossvalidated subsamples of 226 male and 245 female healthy, community-living, middle-class Americans. A log-linear analysis was used to compare the proportion of smokers, ex-smokers, and nonsmokers categorized as users of more or less amounts of coffee and alcohol. Although most of the intercorrelations were not strong, the results indicate that for both sexes, smokers and ex-smokers were more likely than nonsmokers to drink greater amounts of alcohol and coffee. Furthermore, for smokers, ex-smokers, and nonsmokers, a majority of individuals who reported drinking more alcohol also reported drinking more coffee. Interestingly, the coffee and alcohol consumption levels of ex-smokers resembled those of smokers more than those of nonsmokers. Also, ex-smokers reported drinking more wine and decaffeinated coffee than either smokers or nonsmokers. Finally, the number of cigarettes smoked per day (daily quantity) was positively related to total alcohol and coffee consumption in men, but not in women. Further studies are recommended to examine the role of individual differences in the development, maintenance, and modification of these three appetitive habits and their co-occurrence.