Extinction of classically conditioned fear, like its acquisition, is active learning, but little is known about its molecular mechanisms. We recently reported that temporal massing of conditional stimulus (CS) presentations improves extinction memory acquisition, and suggested that temporal spacing was less effective because individual CS exposures trigger two opposing processes: (1) fear extinction, which is favored by CS massing, and (2) fear incubation (increase), which is favored by spacing. We here report the effects of manipulating the adrenergic system during massed or spaced CS presentations in fear-conditioned mice. We administered yohimbine (5 mg/kg), an alpha(2)-receptor antagonist, or propranolol (10 mg/kg), a beta-receptor antagonist, systemically prior to CS presentation sessions and recorded both short- and long-term changes in conditional freezing. Yohimbine treatment facilitated extinction of both cue and context fear with massed protocols. When given before spaced CS presentations, propranolol led to a persistent incubation of cue fear, whereas yohimbine led to persistent extinction, compared with vehicle-treated animals, which showed no change in fear. These results suggest that norepinephrine positively modulates the formation of fear extinction memories in mice. They also provide clear evidence that spaced CS presentations trigger both fear-reducing (extinction) and fear-increasing (incubation) mechanisms. 相似文献
That different amplitudes of muscle activities during various abdominal exercises not only reflect the inherent differences in motor control but movement speed as well was hypothesized. 20 healthy adults (M age = 23 yr.) performed three exercises that involved varying amounts of trunk control: the partial sit-up, full sit-up, and AbSlide roll. Covariate analyses indicated that the amplitude of muscle activities could be partitioned into three categories: motor control and scaling (speed and amplitude), scaling only, and motor control only. Overall, the AbSlide exercise activated the most amount of muscular activity, followed by the full and partial sit-up exercises. Results are discussed in terms of how the various muscles contribute to motor control and velocity scaling. 相似文献
Maternal perceptions of infant soothability moderated the relation between negative infant temperament and maternal sensitivity. Infant negative temperament and maternal sensitivity were significantly positively related when maternal perception of infant soothability was high and significantly negatively related when maternal perception of infant soothability was low. 相似文献
Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety of spatial and aversive learning and memory tasks. The experiments in this study investigated the role galanin has in emotional learning and memory using a standard delay cued and contextual fear conditioning task. Rats were administered galanin into the lateral ventricles before training, and scored for freezing behavior in the same context and in a novel context with and without an auditory cue (CS) that had been paired previously with an aversive stimulus (US). Galanin-overexpressing transgenic mice were tested in an identical behavioral protocol. The galanin-administered rats and the transgenic mice were not significantly different from their respective controls on this task. A more challenging trace cued and contextual fear conditioning procedure was administered to separate groups of galanin-treated rats and galanin-overexpressing transgenic mice. Subjects were trained with the same CS and US, however, a 2.5-sec delay was inserted between CS offset and US onset. Following the trace conditioning, rats administered galanin and mice overexpressing galanin both exhibited significantly less freezing to the CS in the novel context as compared with their control groups. These results indicate that the observed disruption of cued fear conditioning was specific to the more difficult trace conditioning task. These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks. 相似文献
We studied the impact of manner of exploration, orientation, spatial position, and configuration on the haptic Müller-Lyer illusion. Blindfolded sighted subjects felt raised-line Müller-Lyer and control stimuli. The stimuli were felt by tracing with the index finger, free exploration, grasping with the index finger and thumb, or by measuring with the use of any two or more fingers. For haptic judgments of extent a sliding tangible ruler was used. The illusion was present in all exploration conditions, with overestimation of the wings-out compared to wings-in stimuli. Tracing with the index finger reduced the magnitude of the illusion. However, tracing and grasping induced an overall underestimation of size. The illusion was greatly attenuated when stimuli were felt with the index fingers of both hands. Illusory misperception was not altered by the position in space of the Müller-Lyer stimuli. No effects of changes in the thickness of the line shaft were found, but there were effects of the length of the wing endings for the smaller, 5.1 cm stimuli. The theoretical and practical implications of the results are discussed. 相似文献
The field of relationship science began with understanding the role of attraction and has expanded to examine factors associated with relationship initiation, development, and maintenance. Despite the growth of the field, recent reviews of topics present in relationship science have revealed a dearth of literature examining sociocultural contexts that may impact relational processing, especially for traditionally underrepresented groups in science. Notably, given the theories, frameworks, and methods applied in these disciplines, counseling psychology and relationship science are at the forefront of examining such contexts. To this end, the goal of the special issue was to bring together scholars whose work is either an application of or showcases how the contemporary foci of counseling psychology, including but not limited to intersectionality, social justice, cultural competence/humility, identity, strengths-based approaches, and social power hierarchies are applicable to the study of relationships broadly defined. This editorial synthesis provides a brief summary of the four articles that are included in this special issue and ends with recommendations for future research that intersects counseling psychology and relationship science. 相似文献
Translation of promising procedures for mitigating treatment relapse has received considerable attention recently from researchers across the basic–applied continuum. One procedure that has demonstrated mixed support involves increasing the duration of treatment as a strategy for blunting resurgence. In a recent translational study, Greer et al. (2020) failed to detect a mitigation effect of increased treatment duration on the resurgence of destructive behavior. However, design limitations may have been responsible. The present study corrected these limitations by (a) employing a sequential design to decrease the possibility of multiple-treatment interference, (b) evaluating more treatment durations, (c) arranging treatments of fixed durations, and (d) conducting treatments of more extreme duration in a different clinical sample. Despite these improvements in experimental rigor and the testing of more extreme boundary conditions, the present study also failed to detect a mitigation effect of increased treatment duration. Likely explanations are discussed. 相似文献
The Emotion Regulation Questionnaire (ERQ; Gross & John, 2003) assesses two emotion regulation (ER) strategies: cognitive reappraisal and expressive suppression. Researchers have used the ERQ in cross-national studies, such as with participants in Hong Kong. There is inconsistency in psychometric equivalence data for the ERQ in Chinese among adults, and prior research in Hong Kong contradicted the ERQ's original factor structure (Matsumoto et al., 2008). The present study examined the factor structure, reliability and validity of a translated Traditional Chinese-ERQ and the English-ERQ with Hong Kong college students. Results revealed that both versions replicated the original two-factor structure of the ERQ (Gross & John, 2003). Evidence of the measure's convergent, discriminant and predictive validity was obtained as well. Implications for cross-cultural scale validation particularly with Hong Kong Chinese students are discussed. 相似文献
Objective: The purpose of this study was to determine if hostility is associated with physical and mental health-related quality of life (QoL) in US. Hispanics/Latinos after accounting for depression and anxiety.
Methods: Analyses included 5313 adults (62% women, 18–75 years) who completed the ancillary sociocultural assessment of the Hispanic Community Health Study/Study of Latinos. Participants completed the Center for Epidemiological Studies Depression Scale, Spielberger Trait Anxiety Scale, Spielberger Trait Anger Scale, Cook–Medley Hostility cynicism subscale and Short Form Health Survey. In a structural regression model, associations of hostility with mental and physical QoL were examined.
Results: In a model adjusting for age, sex, disease burden, income, education and years in the US., hostility was related to worse mental QoL, and was marginally associated with worse physical QoL. However, when adjusting for the influence of depression and anxiety, greater hostility was associated with better mental QoL, and was not associated with physical QoL.
Conclusions: Results indicate observed associations between hostility and QoL are confounded by symptoms of anxiety and depression, and suggest hostility is independently associated with better mental QoL in this population. Findings also highlight the importance of differentiating shared and unique associations of specific emotions with health outcomes. 相似文献