Potentiation of the pressor response to stress by tolbutamide in dogs

Tolbutamide has previously been shown to amplify the pressor effects of “exogenous” catecholamines in conscious dogs, possibly due to sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. The objective of this study was to examine if tolbutamide also amplifies the pressor effects of “endogenous” catecholamines released during psychological stress (classical Pavlovian aversive conditioning). Experiments were conducted in β-adrenoreceptor-blocked (propranolol, 1 mg/kg, i.v.) conscious dogs (n=4) trained in classical aversive conditioning. Conditioning was accomplished by following a tone (CS+) with a 1/2 second shock; another tone (CS-) was not followed by any shock and served as control. With saline pretreatment, aversive conditioning (i.e., CS+) increased mean arterial pressure (MAP) only by approximately 4.7% when compared to CS-, whereas with tolbutamide (45 mg/kg, i.v.) pretreatment, the increase in MAP induced by CS+ beyond what was induced by the CS- (approximately 6.2%) was significantly (p<0.05) larger than that with saline pretreatment. In isolated canine femoral arterial segments (n=4), the vasoconstrictor effect of phenylephrine (an α₁-agonist) at 5×10^?6M (which was the EC₅₀ value) was amplified by 2×10^?2M of tolbutamide from 54.0±2.0% to 66.9±2.1%. In conclusion, tolbutamide amplifies the pressor effects of “endogenous” catecholamines in conscious dogs, possibly by sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. This mechanism of action is novel and has not been reported with other agents.     

The trait anxiety-perception score: a composite predictor for state anxiety

This article describes the development and initial evaluation of the A-Trait-Perception (ATP) score, a composite predictor for state anxiety. The ATP score is constructed from trait anxiety and situation perception data derived from the Endler Multidimensional Anxiety Scales (EMAS; Endler, Edwards, & Vitelli, 1989). ATP mathematically combines the individual's trait anxiety and situation perception profiles and adjusts these with a multiplier that reflects the individuals' sensitivity to particular types of situational elements in terms of state anxiety inducement. The utility of the resulting composite variable as a predictor of state anxiety was examined in the context of two field studies. Results of both studies indicated that the ATP variable offered a superior prediction of state anxiety, as compared to four individual trait anxiety facets (social evaluation, physical danger, ambiguous and daily routines). The theoretical import of these results is discussed.     

Abbreviated measures of sex role egalitarian attitudes

Alternate 25-item short forms of the Sex-Role Egalitarianism Scale (SRES) were developed and examined for psychometric quality using data from a sample of 608 students. Internal consistency coefficients were .94 and .92 for the two forms, stability coefficients with a three-week test-retest in terval were .88 for each, and the coefficient of equivalence or alternate forms reliability was .87. As expected, females scored significantly more egalitarian than males on both short forms, and results of factor analyses pointed to unidimensional measurement of a single construct for males, females, and the total sample. Additional support for reliability and validity is overviewed. The abbreviated SRES forms appear to provide a psychometrically sound and time-efficient means for assessing egalitarian attitudes.     

Animal research in psychology: declining or thriving?

From Dialog's PsychINFO database the number of studies with 6 species reported in the Psychological Abstracts was calculated for each year from 1967 to 1988. Also, the number of studies with an additional 11 species were calculated for each year from 1973 to 1988. A hand search in the Journal of the Experimental Analysis of Behavior and Learning and Motivation was also conducted to explore trends in studies on 12 species from 1970 to 1987. The numbers of studies on many species (e.g., baboons, bats, chimpanzees, dolphins, gerbils, guinea pigs, gorillas, hamsters, lemurs, mice, pigeons, rats, seals, and snakes) have remained stable. There has, however, been a steady decline in the numbers of studies on selected species (e.g., cats, dogs, and rabbits). Possible reasons for changing trends in studies on selected species include: increased costs, the cognitive emphasis in psychology, and arguably, animal rights activism.     

Diagnosis and Assessment of Depression and Suicidality Using the NIMH Diagnostic Interview Schedule for Children (DISC-2.3)

The Diagnostic Interview Schedule for Children (DISC-2.3) was studied in a sample of 265 adolescent inpatients to determine type and concurrent validity of depressive symptoms and depressive disorder diagnoses for different DISC-2.3 informants (parent, adolescent, both). The Children's Depression Rating Scale — Revised, Reynolds Adolescent Depression Scale (RADS), Suicide Ideation Questionnaire — Junior, Spectrum of Suicide Behavior Scale, and clinical consensus diagnoses were used to assess concurrent validity. Results indicated that (1) parents, compared to adolescents, reported a higher prevalence of all depressive symptoms with the exception of weight change; (2) DISC-2.3 depressive and suicidality symptoms were related positively to independent validating criteria for all informant conditions, suggesting good concurrent validity; (3) the DISC-2.3 both informant condition correctly identified the most depressive disorders; and (4) the parent, but not the adolescent, DISC-2.3 Informant condition contributed to the prediction of clinical consensus diagnoses of depression after taking into account RADS scores.     

The nature and treatment of social phobia in youth

A small proportion of children and adolescents experience a debilitating level of social anxiety, known as social phobia. Initially, we consider the phenomenology and aetiology of social phobia in children and adolescents. A number of age-sensitive assessment instruments or tools are briefly considered: a diagnostic interview, selj-report instruments, behavioural observations, cognitive assessment, self-monitoring and psychophysiological recording. We explore cognitive-behavioural strategies that have been found to be useful in the management of social phobia. Although there is much research support for the efficacy of cognitive-behavioural strategies for adults with social phobia, it is emphasized that controlled evaluations have yet to be undertaken with socially phobic youngsters.     

AN EXPLOSION OF DAZZLING FLASHES: TEILHARD'S UNITY OF FAITH AND SCIENCE

Abstract. Science and revelation have been presented as two books with the same “author,” their reconciliation being called “concordism.” Teilhard opposed concordism, insisting that supposed “revelations” be treated as scientific hypotheses to be verified or not in experience. Applying his criterion for truth (Does it bring “coherence and fecundity” to the phenomena?) to Christian revelation, he told of finding “an explosion of dazzling flashes.” So Teilhard spoke of the hypothesis as the supreme spiritual act wherein the dust of experience takes on form and is kindled at the fire of knowledge.     

Wishes, Motives, Goals, and Personal Memories: Relations of Measures of Human Motivation

ABSTRACT The purpose of this study was to compare measures of explicit and implicit motives. One hundred and one participants completed six measures of motivation, including Thematic Apperceptive stories, autobiographical memories, three wishes, personal striving lists, the Personality Research Form, and self-ratings. Stories, memories, wishes, and strivings were content-analyzed using Winter's (1989) system. Although overall correlations did emerge among explicit measures within the same motive, there were numerous correlations among methodologically similar measures of different motives. In general, explicit measures did not correlate with thematic measures of the same motives. Although correlations among measures were similar for men and women, explicit measures of power converged with thematic measures of power only for men. Exploratory factor analysis identified three factors: explicit achievement, explicit affiliation, and power. Implicit achievement motivation loaded negatively on the affiliation factor. Implications for research on implicit and self-attributed motivation are discussed.     

Aesthetic preference and DSM-IIIR personality disorders

This report tested whether those individuals with a cluster B DSM-IIIR personality disorder (narcissistic, borderline, antisocial or histrionic) had higher scores for aesthetic preference for visually complex drawings using the Barron-Welch Art Scale. In a sample of 141 patients and controls, the 56 subjects who met the criteria for one of the cluster B personality disorder diagnoses displayed higher Barron-Welch Art Scale Scores. A multiple regression analysis showed that narcissistic and borderline personality disorder contributed positively, while dependent personality disorder, negatively to preference for complexity. The findings support the notion that aesthetic choices and values reflected through the dimension of openness to experience may contribute to the behavioral manifestations of the personality disorders.     

A study of neuropsychological impairment among school-indentified learning-disabled students

This investigation examined the proportion of school-identified learning-disabled (LD) students who scored in the impaired range on the Halstead Reitan Neuropsychological Battery for Children (HNBC) over a 20-year period. A difference was noted in findings for periods before and after the passage of federal legislation (Public Law 94-142); specifically, the proportion of LD students who scored in the impaired range on neuropsychological tests was significantly higher prior to than after this law. A similar pattern of impaired performance across the different tests was noted before and after the legislation. The implications of these results for theorists and practitioners are discussed.