Differential involvement of M1-type and M4-type muscarinic cholinergic receptors in the dorsomedial striatum in task switching

Previous experiments have demonstrated that the rat dorsomedial striatum is one brain area that plays a crucial role in learning when conditions require a shift in strategies. Further evidence indicates that muscarinic cholinergic receptors in this brain area support adaptations in behavioral responses. Unknown is whether specific muscarinic receptor subtypes in the dorsomedial striatum contribute to a flexible shift in response patterns. The present experiments investigated whether blockade of M1-type and/or M4-type cholinergic receptors in the dorsomedial striatum underlie place reversal learning. Experiment 1 investigated the effects of the M1-type muscarinic cholinergic antagonist, muscarinic-toxin 7 (MT-7) infused into the dorsomedial striatum in place acquisition and reversal learning. Experiment 2 investigated the effects of the M4-type muscarinic cholinergic antagonist, muscarinic-toxin 3 (MT-3) injected into the dorsomedial striatum in place acquisition and reversal learning. All testing occurred in a modified cross-maze across two consecutive sessions. Bilateral injections of MT-7 into the dorsomedial striatum at 1 or 2 microg, but not 0.05 microg impaired place reversal learning. Analysis of the errors revealed that MT-7 at 1 and 2 microg significantly increased regressive errors, but not perseverative errors. An injection of MT-7 2 microg into the dorsomedial striatum prior to place acquisition did not affect learning. Experiment 2 revealed that dorsomedial striatal injections of MT-3 (0.05, 1 or 2 microg) did not affect place acquisition or reversal learning. The findings suggest that activation of M1-type muscarinic cholinergic receptors in the dorsomedial striatum, but not M4-type muscarinic cholinergic receptors facilitate the flexible shifting of response patterns by maintaining or learning a new choice pattern once selected.     

Childhood-onset multiple sclerosis and mood disorders: a case study.

Multiple Sclerosis (MS) is rare in children. Little research exists regarding emotional and behavioral disorders in childhood-onset MS, despite the occurrence of such problems in adults with MS. This paper describes the cognitive and behavioral characteristics of a boy diagnosed with MS at age 9 and mood disorder at age 10. He displayed no cognitive or behavioral problems prior to the onset of physical symptoms of MS. Three years after diagnosis, this child showed persistent problems with speed of processing, visual-motor skills, and parent and teacher-reported executive functioning. In addition, he had difficulties with emotional lability, behavioral disinhibition, depression, and social interaction. As with adults, children with MS may be at increased risk for mood disorder compared to their peers. Mood disorders in children with MS are likely to be multiply determined, although the specific causal mechanisms are unknown.     

Modernity and childrearing in families of Gujarati Indian adolescents

Over the last two decades, researchers have devoted increasing attention to the role of cognitive factors in parenting. These cognitive mediational models focus on the role of attitudes, beliefs, and knowledge in influencing parenting behaviours. A cognitive factor that contributes to cultural variation in parenting is attitudinal modernity—a broad concept that refers to the “Westernization” of attitudes in such diverse areas as gender role conceptions, political attitudes, attitudes toward authority, the family, and religious beliefs. Modernity has been most useful in describing the attitudes of individuals from countries undergoing the rapid social and economic changes that accompany industrialism and urbanization. The present study focused on India—a country currently undergoing such changes. Despite the wide range of modern and traditional beliefs among contemporary Indian parents, our understanding of the determinants of these individual differences is limited. The purpose of the present study was to examine the relation between modernity and parental childrearing practices, as well as to examine the relation between adolescent modernity and parental childrearing. Mothers, fathers, and adolescents in 50 Hindu, Gujarati families completed questionnaires about the modernity of their attitudes and were interviewed about parental childrearing practices. Parental and adolescent modernity were highly correlated. Moreover, parental modernity predicted the nature of parental childrearing values and practices, and parental childrearing values predicted adolescent modernity. Although the findings varied somewhat for mothers versus fathers, parental modernity was associated with individualistic childrearing values and practices, and parents who valued individualistic characteristics in their adolescents had sons and daughters who reported the highest levels of modernity. Implications for understanding the role of mothers and fathers in the socialization of modernity are considered.     

Structural integration in language and music: Evidence for a shared system

In this study, we investigate whether language and music share cognitive resources for structural processing. We report an experiment that used sung materials and manipulated linguistic complexity (subject-extracted relative clauses, object-extracted relative clauses) and musical complexity (in-key critical note, out-of-key critical note, auditory anomaly on the critical note involving a loudness increase). The auditory-anomaly manipulation was included in order to test whether the difference between in-key and out-of-key conditions might be due to any salient, unexpected acoustic event. The critical dependent measure involved comprehension accuracies to questions about the propositional content of the sentences asked at the end of each trial. The results revealed an interaction between linguistic and musical complexity such that the difference between the subject- and object-extracted relative clause conditions was larger in the out-of-key condition than in the in-key and auditory-anomaly conditions. These results provide evidence for an overlap in structural processing between language and music.     

Psychological disturbance,social support and stressors: A community survey of immigrant Asian women and the indigenous population

The purpose of this community survey was to examine the differences in psychological symptom levels, social support, stressors and the awareness and use of local social services between the Asian and the indigenous groups. The theoretical starting point lies in the idea that the Asian group would have experienced considerable stress, partly as a resuldt of their being immigrants, and that the traditional extended family common to them may be an important source of social support. The relationship between psychological symptom levels and social support was examined to test the hypothesis that they might be related. Forty immigrant Asian women and 40 indigenous women were randomly selected from the Electroral Register, 1988, using quota-sampling techniques. All subjects were interviewed in their own homes and in their native languages by volunteer interviewers. In comparison with the Indigenes, the Asians had higher symptom levels; smaller, denser, less dispersed social support networks composed of mainly kin members; they reported more stressors related to their migrant status, and they had a lower awareness and usage of local social services. A relationship between psychological disturbance and social support was found, yielding inconsistent results regariding the direction of the relationship. Limitations of the study were outlined with implications of the results and indications for future research discussed.     

Do the magnocellular and parvocellular visual pathways contribute differentially to subitizing and counting?

We investigated the neurobiologies! basis of visual processes involved in object enumeration. Subitizing, the ability to rapidly and accurately enumerate four or fewer objects, is thought to depend on preattentive processing of visual stimuli, whereas counting of more numerous objects is thought to require serial shifts of attention. We attempted to distinguish between the hypothesis that the magnocellular (M) visual pathway is the preferential route for subitizing, and the alternative hypothesis that there is no selectivity for the M pathway or its counterpart, the parvocellular (P) visual pathway, in visual object enumeration. Green rectangles were presented on an equiluminant red background to impair M pathway processing. This slowed enumeration performance relative to a control condition in which object/background luminance differed, especially when the rectangles were relatively large and widely spaced and had constant retinal eccentricity. When low luminance contrast was used to impair processing along the P pathway, enumeration performance was slowed relative to a high-contrast control condition, especially when the rectangles were small and closely spaced. Overall, our manipulations affected enumeration performance without selectivity for subitizing or counting ranges and without altering the slope of the functions relating reaction time to numerosity. Thus, our results favor the hypothesis that visual enumeration does not depend preferentially on either the M or the P pathway.     

A COMPARISON OF SENSORY INTEGRATIVE AND BEHAVIORAL THERAPIES AS TREATMENT FOR PEDIATRIC FEEDING DISORDERS

We compared the effects of escape extinction (EE) plus noncontingent reinforcement (NCR) with sensory integration therapy as treatment for the feeding problems of 2 children. Results indicated that EE plus NCR was more effective in increasing acceptance, decreasing inappropriate behavior, and increasing amount consumed relative to sensory integration for both children. The results are discussed in terms of the challenges of evaluating sensory‐integration‐based treatments, and the reasons why component analyses of multicomponent treatments like sensory integration are important.     

Cross-Cultural Attitude Assessment With the Miale-Holsopple Sentence Completion Test

Certain sentence stems in the 73 item Miale-Holsopple Sentence Completion Test can be interpreted as open-ended attitude questions, revealing world views in particular societies. Sentence stems #7, "The easiest way to get money;" #8, "Twenty years from now;" #18, "The white girl who married the black man;" #48, "A naked man;" and #54, "A woman's body" were selected for cross-cultural study. Thirty-nine American college students answered the standard form of the Miale-Holsopple, and 60 Brazilian students answered a Portuguese version of this test. American students gave more positive work ethic responses to stems #7 and #8 and more negative responses to interracial marriages than did Brazilians. The Brazilian females gave more positive responses to stem #54 than did American women.     

The development of perceptual grouping biases in infancy: A Japanese-English cross-linguistic study

Perceptual grouping has traditionally been thought to be governed by innate, universal principles. However, recent work has found differences in Japanese and English speakers’ non-linguistic perceptual grouping, implicating language in non-linguistic perceptual processes (Iversen, Patel, & Ohgushi, 2008). Two experiments test Japanese- and English-learning infants of 5–6 and 7–8 months of age to explore the development of grouping preferences. At 5–6 months, neither the Japanese nor the English infants revealed any systematic perceptual biases. However, by 7–8 months, the same age as when linguistic phrasal grouping develops, infants developed non-linguistic grouping preferences consistent with their language’s structure (and the grouping biases found in adulthood). These results reveal an early difference in non-linguistic perception between infants growing up in different language environments. The possibility that infants’ linguistic phrasal grouping is bootstrapped by abstract perceptual principles is discussed.