Multiunit changes in hippocampus and medial geniculate body in free-behaving rats during acquisition and retention of a conditioned response to a tone

Multiunit activity (MUA) was recorded chronically in the hippocampus (CA3) and the medial geniculate body (mMG) during habituation to a tone followed by conditioning (tone paired with footshock) or pseudoconditioning (tone/footshock unpaired) in rats previously trained in a lever-pressing for food task (VI 60). In the conditioned group pairing tones with footshocks rapidly induced an increase in the initial CS-evoked response in the mMG, followed by the emergence of a hippocampal response and a marked conditioned suppression of lever-pressing to the tone. In contrast, in the pseudoconditioned group, the stimulus induced only transient cellular changes in the hippocampus and in the mMG, while no behavioral suppression to the tone could be seen. Moreover, presentations of the CS 45 days later induced multiunit and behavioral responses in both structures, only in the conditioned group. These results are used for discussion of the role of learning-induced changes in the sensory structure (mMG) as compared with changes in an associative structure (hippocampus), during acquisition and retention of a conditioned response.     

Learning from lectures: The effect of varying the detail in lecture handouts on note-taking and recall

Previous research on the effect of lecture handouts on student learning indicates that students who are given skeletal handouts usually perform better in course examinations than students who take all their own notes. The present study investigates whether the amount of detail in the handout is a critical factor in this. A randomized groups experiment was conducted in the context of a course on dental surgery. Four lecture handout conditions (headings and full text; headings and key points; headings only; no supplementary materials) were compared on tests 2 days and 2 weeks after the lecture. The significant differences between conditions were: ‘headings only’ better than ‘headings and key points’ on the first test; ‘headings only’ better than ‘no supplementary materials’ on the second test; and ‘headings and full text’ better than ‘no supplementary materials’ on the second test. These results indicate that the amount of detail is a critical factor in handout effectiveness.     

Knowledge in society: anatomy of an emergent field

An emergent social science of knowledge applications, drawing on a substantial multidisciplinary literature published over the past twenty-five years, signals an inversion of typical scholarly reasoning about the knowledge-society nexus. Whereas most scholarly research thus far has concentrated on conditions believed to affect the production of scientific and professional knowledge, we pose a new problematic: What must we examine in order to comprehend and consciously shape applications of scientific and professional knowledge to the manifold problems facing contemporary societies? To date, approaches to this problematic have proceeded on the basis of four broadly accepted if abstract theses about the nature of contemporary knowledge systems: subjectivity, corrigibility, sociality, and complexity. Within the boundaries supplied by these commonly accepted theses are unresolved controversies expressed in competing visions of complexity, alternative perspectives of causation, rival images of progress, and conflicting criteria of application.     

Burden of proof

This paper presents an analysis of the concept of burden of proof in argument. Relationship of burden of proof to three traditional informal fallacies is considered: (i) argumentum ad hominem, (ii) petitio principii, and (iii) argumentum ad ignorantiam. Other topics discussed include persuasive dialoque, pragmatic reasoning, legal burden of proof, plausible reasoning in regulated disputes, rules of dialogue, and the value of reasoned dialogue.     

A high-gain,low-noise amplifier for EEG

This paper describes an amplifier for an electroencephalograph with gain of 1×10⁴ to 1×10⁶ and made entirely of commercially available IC components. The two-stage amplifier has a preamplifier stage with fixed gain of 1000, and a second stage with variable gain from 1 to 100. The final stage, an anti-aliasing filter, adds a gain of 10 to the signal. The circuit has high common mode rejection, low input bias current, very low noise characteristics, low offset voltages, and offset nulling capability built into the circuit.     

Malevolent object representations in borderline personality disorder and major depression.

To study malevolent representations, earliest memories were reliably coded on scales of affect tone. Ss were diagnosed with borderline personality disorder: 31 without and 30 with concurrent major depression. Nonborderline comparison subjects had either major depressive disorder (n = 26) or no psychiatric diagnosis (n = 30). Borderline subjects were discriminated from comparison subjects by their more malevolent representations; they more frequently produced memories involving deliberate injury; and they portrayed potential helpers as less helpful. Results suggest the diagnostic significance of malevolent representations, which need to be explained by any theory of borderline personality disorder.