Drug Tolerance, Drug Addiction, and Drug Anticipation

ABSTRACT— Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration. Conditional responses occur in the presence of cues that have been associated with the drug in the past, such as the setting in which the drug was taken. These conditional responses mediate the expression of tolerance and withdrawal symptoms. Recently, it has become apparent that internal predrug cues, as well as environmental cues, elicit pharmacological conditional responses that contribute to tolerance and withdrawal. Such internal cues include cognitive or proprioceptive cues incidental to self-administration, drug-onset cues that are experienced shortly after administration, and emotional cues. According to the conditioning analysis, addiction treatment should incorporate learning principles to extinguish the association between stimuli (environmental and internal) present at the time of drug administration and the effects of the addictive drug.     

Very brief exposure II: the effects of unreportable stimuli on reducing phobic behavior

This experiment compared the effects of exposure to masked phobic stimuli at a very brief stimulus-onset asynchrony on spider-phobic and non-phobic individuals. Participants were identified through a widely used questionnaire and a Behavioral Avoidance Test (BAT) with a live, caged tarantula to establish baseline levels of avoidance. One week later, they were individually administered one of two continuous series of masked images: spiders or flowers. Preliminary masking experiments showed that independent samples of participants from the same populations failed to recognize these stimuli. Participants in the main experiment reported ratings of subjective distress immediately before and after the exposure manipulation. Then they engaged in the BAT once again. Very brief exposure to images of spiders reduced phobic participants' avoidance of the tarantula. No effects were evidenced on subjective distress, or on non-phobic participants. Theoretical implications for the non-conscious basis of fear are discussed.     

Dying for romance: risk taking as purposive behavior

Many approaches have been utilized to understand adolescent risk taking. The current research frames risk taking as a purposive behavior enacted with a specific goal in mind. Rather than assuming adolescent risk taking to be the result of arrogance or perceived invulnerability, adolescent risk taking is interpreted as a means to an end. Stemming from a Tolmanian framework, an alternative explanation for adolescent risk taking is tested: adolescents are willing to take risks to the extent that the risk is associated with a needed outcome - the greater the need for the outcome, the greater the willingness to take risks. To test the proposed hypothesis, 192 participants completed a survey about their need for a romantic relationship and their willingness to endure harm to obtain a romantic relationship. Data were collected at two time points. A hierarchical regression revealed that need for romance is a significant predictor of willingness to endure harm for romance, even after gender and sensation seeking are statistically controlled. Moreover, need for romance at T1 was shown to be predictive of harm for romance at T2. Results are supportive of taking a purposive - that is, Tolmanian - approach, as a means for interpreting adolescent behavior.     

Splitting as a Focus of Couples Treatment

Current developments in neurophysiology and trauma have re-awakened interest in the reciprocal influences of the interpersonal and intrapsychic domains. Although object relations theory continues to guide clinical practice, its integration into models of best practice has been limited by a lack of empirical study. This paper examines the defense mechanism of splitting in couples from the theoretical, empirical and clinical perspectives in ways that allow for integration with research findings. It is proposed that splitting operates on a continuum from a specific response that is stimulated by anxiety, to a fundamental style of relating that is marked by emotional reactivity, impaired problem solving and relationship instability. Specific treatment interventions that integrate object relations and cognitive perspectives are summarized.     

The intergenerational transmission of social dominance: A three‐generation study

This study examined the transmission of social dominance orientation (SDO) from parents and grandparents to children. It was predicted that parents as well as grandparents would pass their social dominance attitudes to children. Children's levels of SDO would thus be the highest when parental and grandparental attitudes are high; the lowest when parental and grandparental attitudes are low; and intermediate when parental and grandparental attitudes are incongruent. These hypotheses were examined in a sample of 93 families including children (in early adulthood), one of their parents, and one of their grandparents. Results yielded support for the predictions. These findings' implications are discussed in terms of their potential to explain previous inconsistent results on the transmission of social attitudes to children. Copyright © 2008 John Wiley & Sons, Ltd.     

Overcoming adolescents' resistance to anti-inhalant appeals.

This research was concerned with factors that affect adolescents' evaluations of persuasive anti-inhalant messages and the association of these evaluations with usage intentions. Sixth and 7th graders (N=894) received anti-inhalant messages that varied as a result of the factorial combination of message source (doctor or peer), suggested harm (social or physical), and target (message was addressed directly or indirectly to receivers). Manipulated variables were crossed with inhalant-user status (resolute nonuser, vulnerable nonuser, and user). Significant (p<.01) target and status effects on message evaluation were found. Significant interactions of status with each of the manipulated variables also emerged. Users were resistant to threatened physical harms, but suggested harms did not differentially affect resolute nonusers or vulnerable nonusers. Users and vulnerable nonusers evaluated the message more positively when targeted indirectly (p<.05). Vulnerable nonusers were more receptive to peer sources, whereas users preferred adult sources. Message evaluation was significantly associated with inhalant usage intentions (r=-.22), and this association held even after the contributions of sex, sensation seeking, acculturation, prior use, familism, and assumed peer usage were accounted for in a multiple regression analysis (overall R(2)=.24).     

THE VISUAL EXPERIENCE OF CAUSATION

The thesis that we can visually perceive causal relations is distinct from the thesis that visual experiences can represent causal relations. I defend the latter thesis about visual experience, and argue that although they are suggestive, the data provided by Albert Michotte's experiments on perceptual causality do not establish this thesis. Turning to the perception of causality, I defend the claim that we can perceive causation against the objection that its arcane features are unlikely to be represented in experience.     

Conventionality in family conversations about everyday objects

Children's developing understanding that words have conventional meanings and objects have conventional functions emerges in parent-child activity and conversation. Drawing on family conversations in everyday settings, the chapter explores an apparent paradox between a global analysis of conventionality as stable shared knowledge and a local notion of conventions as flexibly negotiated in activity.