Making the Decision to Participate in Predictive Genetic Testing for Arrhythmogenic Right Ventricular Cardiomyopathy

This paper describes the experience of predictive genetic testing for Arrhythmogenic Right Ventricular Cardiomyopathy in the context of novel gene discovery. Two approaches to making the decision to engage in genetic testing were apparent: the decision to be tested either (a) develops gradually over time or (b) happens so quickly that it is felt as a “fait accompli.” Six key factors that influenced the particular approach taken by the participants were identified: (1) scientific process—available and relevant predictive genetic test; (2) numerous losses or deaths within the family; (3) physical signs and symptoms of disease; (4) gender; (5) sense of relational responsibility or moral obligation to other family members; and (6) family support. This study found that at risk individuals juxtapose scientific knowledge against their experiential knowledge and the six identified factors in order to make the decision to participate in genetic testing. Recommendations include the creation of a relational space within which to provide psychological counselling and assessment for the six identified factors that shape the decision to engage in predictive genetic testing.     

Behavioral pharmacology of the odor span task: Effects of flunitrazepam,ketamine, methamphetamine and methylphenidate

The Odor Span Task is an incrementing non‐matching‐to‐sample procedure that permits the study of behavior under the control of multiple stimuli. Rats are exposed to a series of odor stimuli and selection of new stimuli is reinforced. Successful performance thus requires remembering which stimuli have previously been presented during a given session. This procedure has been frequently used in neurobiological studies as a rodent model of working memory; however, only a few studies have examined the effects of drugs on performance in this task. The present experiments explored the behavioral pharmacology of a modified version of the Odor Span Task by determining the effects of stimulant drugs methylphenidate and methamphetamine, NMDA antagonist ketamine, and positive GABA_A modulator flunitrazepam. All four drugs produced dose‐dependent impairment of performances on the Odor Span Task, but for methylphenidate and methamphetamine, these occurred only at doses that had similar effects on performance of a simple odor discrimination. Generally, these disruptions were based on omission of responding at the effective doses. The effects of ketamine and flunitrazepam were more selective in some rats. That is, some rats tested under flunitrazepam and ketamine showed decreases in accuracy on the Odor Span Task at doses that did not affect simple discrimination performance. These selective effects indicate disruption of within‐session stimulus control. Overall, these findings support the potential of the Odor Span Task as a baseline for the behavioral pharmacological analysis of remembering.     

Integrating Objective and Subjective Social Class to Advance Our Understanding of Externalizing Problem Behavior in Children and Adolescents: A Conceptual Review and Model

Clinical Child and Family Psychology Review - Extant research has identified both objective measures of socioeconomic status (SES) and subjective social class (SSC) as important predictors of...     

The 2nd to 4th digit ratio (2D:4D) and eating disorder diagnosis in women

Eating disorders are more common in females than in males and are believed to be caused, in part, by biological and hormonal factors. Digit ratio or 2D:4D (the ratio of the 2nd to the 4th digit) is considered to be a proxy for prenatal testosterone (PT) and prenatal oestrogen (PE) exposure. However, how 2D:4D may be related to type of eating pathology is unknown. The relationship between 2D:4D and eating disorder diagnosis was investigated in recovered and currently eating disordered (n = 31) and control (n = 99) women. Mean 2D:4D ratio was significantly lower (indicating higher levels of PT and lower levels of PE) in anorexic (AN) compared to bulimic (BN) women, with controls intermediary. In eating disordered women, 2D:4D was positively and significantly related to current weight, lowest weight and current BMI, with strongest associations for right 2D:4D. Among women, low 2D:4D is related to AN and high 2D:4D to BN, suggesting a differential causal influence of prenatal sex hormones on later eating pathology.     

Vection in depth during consistent and inconsistent multisensory stimulation

We examined vection induced during physical or simulated head oscillation along either the horizontal or depth axis. In the first two experiments, during active conditions, subjects viewed radial-flow displays which simulated viewpoint oscillation that was either in-phase or out-of-phase with their own tracked head movements. In passive conditions, stationary subjects viewed playbacks of displays generated in earlier active conditions. A third control, experiment was also conducted where physical and simulated fore-aft oscillation was added to a lamellar flow display. Consistent with ecology, when active in-phase horizontal oscillation was added to a radial-flow display it modestly improved vection compared to active out-of-phase and passive conditions. However, when active fore-aft head movements were added to either a radial-flow or a lamellar-flow display, both in-phase and out-of-phase conditions produced very similar vection. Our research shows that consistent multisensory input can enhance the visual perception of self-motion in some situations. However, it is clear that multisensory stimulation does not have to be consistent (i.e., ecological) to generate compelling vection in depth.     

National Trends in Implementing Wraparound: Results from the State Wraparound Survey

The wraparound process has been promoted in the children’s services field as a mechanism to achieve collaborative service planning and delivery for families of young people with complex emotional and behavioral needs that span multiple agencies. We compared results of two surveys of state children’s mental health directors, completed in 1998 and 2008, to derive estimates of the extent of wraparound implementation in the United States and to better understand trends in how wraparound has been implemented and supported over time. Results from 2008 found that 88% of states reported having some type of wraparound program that conformed to the definition and provided an estimate of 100,000 children and families served via wraparound in that year. Between 1998 and 2008, states reported increased application of wraparound standards, a greater number of agencies involved in wraparound initiatives, and more formal evaluations of wraparound initiatives. Results provide substantiation of the widespread implementation of wraparound implementation in the United States, and evidence that the model is becoming more consistently supported by formal implementation structures over time.     

When story characters communicate: readers’ representations of characters’ linguistic exchanges

Klin, Ralano, and Weingartner (2007) found transfer effects when a phrase, described as part of a note one character had left for another, was repeated across two passages. However, when the phrase was part of a note in story A and part of a conversation in story B, transfer effects were eliminated (Klin & Drumm, 2010). Klin and Drumm concluded that readers encoded the perceptual features of story characters’ linguistic exchanges and that the mismatch (visual vs. auditory) eliminated transfer effects. The present experiments support this conclusion and also demonstrate that readers encode details of the social interaction that surrounds the characters’ linguistic exchanges: Effects were reduced when the phrase in story A was part of a direct social interaction between the characters (e.g., phone conversation), whereas in story B, the interaction was indirect (e.g., voicemail). More generally, readers are exquisitely tuned to subtle aspects of characters’ linguistic exchanges.     

Comparing measures of attachment: "To whom one turns in times of stress", parental warmth, and partner satisfaction

The Attachment and Clinical Issues Questionnaire (ACIQ; M. A. Lindberg & S. W. Thomas, 2011), was developed over an 18-year period containing 29 scales. The purpose of the present study was to test (a) the validity of the attachment scales in terms of how they predict to whom one turns in times of stress and for affective sharing, and (b) how the attachment scales compared with the Experiences in Close Relationship Questionnaire (ECR) in terms of concurrent, convergent, and discriminant evidence. The relevant secure scales of the ACIQ predicted to whom one turned in study 1, and study 2 demonstrated good convergent evidence with the ECR, but superior concurrent evidence in predicting partner satisfaction, and superior discriminant evidence in differentially correlating with mother and father warmth. Thus, the ACIQ passed essential validity and psychometric tests and was a more robust measure than the ECR with these defining characteristics of attachment.