Behavioral pharmacology of the odor span task: Effects of flunitrazepam,ketamine, methamphetamine and methylphenidate

The Odor Span Task is an incrementing non‐matching‐to‐sample procedure that permits the study of behavior under the control of multiple stimuli. Rats are exposed to a series of odor stimuli and selection of new stimuli is reinforced. Successful performance thus requires remembering which stimuli have previously been presented during a given session. This procedure has been frequently used in neurobiological studies as a rodent model of working memory; however, only a few studies have examined the effects of drugs on performance in this task. The present experiments explored the behavioral pharmacology of a modified version of the Odor Span Task by determining the effects of stimulant drugs methylphenidate and methamphetamine, NMDA antagonist ketamine, and positive GABA_A modulator flunitrazepam. All four drugs produced dose‐dependent impairment of performances on the Odor Span Task, but for methylphenidate and methamphetamine, these occurred only at doses that had similar effects on performance of a simple odor discrimination. Generally, these disruptions were based on omission of responding at the effective doses. The effects of ketamine and flunitrazepam were more selective in some rats. That is, some rats tested under flunitrazepam and ketamine showed decreases in accuracy on the Odor Span Task at doses that did not affect simple discrimination performance. These selective effects indicate disruption of within‐session stimulus control. Overall, these findings support the potential of the Odor Span Task as a baseline for the behavioral pharmacological analysis of remembering.     

Posttraumatic stress and depression: potential pathways to disease burden among heart failure patients

Background and Objectives: Posttraumatic stress disorder (PTSD) and Major Depressive Disorder (MDD) are associated with high disease burden. Pathways by which PTSD and MDD contribute to disease burden are not understood. Design: Path analysis was used to examine pathways between PTSD symptoms, MDD symptoms, and disease burden among 251 low-income heart failure patients. Methods: In Model 1, we explored the independent relationship between PTSD and MDD symptoms on disease burden. In Model 2, we examined the association of PTSD symptoms and disease burden on MDD symptoms. We also examined indirect associations of PTSD symptoms on MDD symptoms, mediated by disease burden, and of PTSD symptoms on disease burden mediated by MDD symptoms. Results: Disease burden correlated with PTSD symptoms (r = .41; p < .001) and MDD symptoms (r = .43; p < .001) symptoms. Both models fit the data well and displayed comparable fit. MDD symptoms did not mediate the association of PTSD symptoms with disease burden. Disease burden did mediate the relationship between PTSD symptoms and MDD symptoms. Conclusions: Results support the importance of detection of PTSD in individuals with disease. Results also provide preliminary models for testing longitudinal data in future studies.     

Making the Decision to Participate in Predictive Genetic Testing for Arrhythmogenic Right Ventricular Cardiomyopathy

This paper describes the experience of predictive genetic testing for Arrhythmogenic Right Ventricular Cardiomyopathy in the context of novel gene discovery. Two approaches to making the decision to engage in genetic testing were apparent: the decision to be tested either (a) develops gradually over time or (b) happens so quickly that it is felt as a “fait accompli.” Six key factors that influenced the particular approach taken by the participants were identified: (1) scientific process—available and relevant predictive genetic test; (2) numerous losses or deaths within the family; (3) physical signs and symptoms of disease; (4) gender; (5) sense of relational responsibility or moral obligation to other family members; and (6) family support. This study found that at risk individuals juxtapose scientific knowledge against their experiential knowledge and the six identified factors in order to make the decision to participate in genetic testing. Recommendations include the creation of a relational space within which to provide psychological counselling and assessment for the six identified factors that shape the decision to engage in predictive genetic testing.     

Dyad Practice Impacts Self-Directed Practice Behaviors and Motor Learning Outcomes in a Contextual Interference Paradigm

We studied dyad practice to determine whether and how alternating practice blocks with a partner impacts self-directed practice scheduling, learning, and perceptions of practice. Participants were assigned to be Partner 1 (P1) or 2 (P2). P1s had a blocked, random, or self-directed schedule, while all P2s self-directed practice of 3, differently-timed keystroke-sequences. P2s showed both own error-dependent practice (switching sequences following better performance) and partner-dependent practice, with the partner's schedule impacting sequence selection and switching frequency. A partner's schedule also impacted learning. Random practice resulted in better timing accuracy than blocked practice for both partners in an immediate and delayed retention test. These data give evidence that self-directed practice behaviors and learning outcomes are modulated by a partner's practice schedule.     

Integrating Objective and Subjective Social Class to Advance Our Understanding of Externalizing Problem Behavior in Children and Adolescents: A Conceptual Review and Model

Clinical Child and Family Psychology Review - Extant research has identified both objective measures of socioeconomic status (SES) and subjective social class (SSC) as important predictors of...     

The Effects of Stereotyping and Implicit Theory on Benevolent Prejudice Toward Aboriginal Canadians

Stereotyping and implicit theory on benevolent prejudice toward an Aboriginal student were investigated in a mock work setting. In a 2 (Stereotype: prime vs. no prime) × 2 (Theory: entity vs. incremental) × 2 (Race: Aboriginal vs. Caucasian) between‐subjects design, non‐Aboriginal participants were primed or not primed with a negative Aboriginal stereotype and an entity or incremental implicit theory before evaluating an Aboriginal or Caucasian student. Consistent with a benevolent prejudice perspective, when primed with the stereotype, only participants holding an entity theory expressed greater desire to help the Aboriginal compared to the Caucasian candidate, despite both candidates demonstrating identical performance information. Implications for prejudice in work environments are discussed.     

Addressing Unintended Consequences of Gender Diversity Interventions on Women’s Sense of Belonging in STEM

Sex Roles - Validated interventions that increase bias literacy (i.e., knowledge of gender bias) and decrease sexism are critical to addressing pervasive gender biases in science, technology,...     

Police endorsement of color‐blind racial beliefs and propensity to interact with youth of color

The beliefs of police, as the point of first contact with the justice system, may help to explain disproportionate minority contact between police and young people. Color‐blind racial beliefs, a form of implicit racism in which racial differences are denied, are more strongly endorsed by police than by laypeople. Using a 2 (youth race) × 3 (offense severity) experimental design, 339 officers participated in an online study examining the influence of youth race, offense severity, and officers' color‐blind racial beliefs on officers' reported likelihood of interacting with young people. Officers with lower levels of color‐blind beliefs reported they would be less likely to interact with Black youth. Additionally, attrition analyses indicated that officers assigned to the Black youth condition were more likely to drop out when asked to complete the measure of color‐blind beliefs. Policy and practice implications are discussed, with a focus on promoting greater discussion of color‐blind ideologies in multicultural trainings for police officers and increasing frank discussions about race and racial issues.