Integrating biological and social processes in relation to early-onset persistent aggression in boys and girls

This study examined the relationship between biological and social risk factors and aggressive behavior patterns in an Australian high-risk sample of 370 adolescents. Perinatal, temperamental, familial, sociodemographic, and behavioral data were collected during interviews completed during pregnancy. immediately postpartum, and when the children were 6 months old and 5, 14, and 15 years old. Youths were given tests of verbal and neuropsychological functioning at the age 5 and age 15 follow-ups. Youths were divided into early-onset persistent aggression, adolescent-onset aggression, and nonaggressive behavior groups. Results revealed that the interaction of biological and social risk factors was significantly related to early-onset persistent aggression. Gender and developmental phase of measurement moderated the relationship between biosocial risks and the outcomes of early-onset persistent aggression and adolescent-onset aggression.     

Low doses of interleukin-1beta improve the leverpress avoidance performance of Sprague-Dawley rats

Recent research has indicated that the pro-inflammatory cytokines, particularly interleukin-1beta (IL-1beta), can affect learning and memory. We injected male Sprague-Dawley rats with IL-1beta (1.0, 3.0, or 6.0 microg/kg, i.p.) or saline vehicle, 24h before a single 4-h session of leverpress escape/avoidance conditioning. No effect of IL-1beta at any dose was observed in the number of escape responses across the 4-h session. However, subjects treated with the two lower doses (1.0 and 3.0 microg/kg) of IL-1beta performed more avoidance responses during the final hour of the 4-h session than the other two groups. Subjects treated with the highest dose of IL-1beta (6.0 microg/kg) did not differ from controls. Results are discussed in terms of the possible mechanisms behind the IL-1beta-induced enhancement of learning, as well as the observed dose-response relationship.     

Examining congruence between partners' perceived infertility-related stress and its relationship to marital adjustment and depression in infertile couples

Because studies examining the emotional impact of infertility-related stress generally focus on individuals, there has been little research examining how relationship and individual variables are linked. The purpose of this study was to explore the impact of congruence (e.g., agreement) between partner's perceived infertility-related stress and its effects on depression and marital adjustment in infertile men and women. Couples referred for infertility treatments at a University-affiliated teaching hospital completed the Fertility Problem Inventory (FPI), the Beck Depression Inventory (BDI), and the Dyadic Adjustment Scale (DAS) 3 months prior to their first treatment cycle. Study findings show that men and women in couples who perceived equal levels of social infertility stress reported higher levels of marital adjustment when compared to men and women in couples who perceived the stress differently. In addition, women in couples who felt a similar need for parenthood reported significantly higher levels of marital satisfaction when compared to women in couples where the males reported a greater need for parenthood. While couple incongruence was unrelated to depression in males, incongruence over relationship concerns and the need for parenthood was related to female depression. These findings provide initial support for the theory that high levels of agreement between partners related to the stresses they experience help them successfully manage the impact of these stressful life events. Possibilities for future research examining the construct of couple congruence are discussed.     

Aging, parafoveal preview, and semantic integration in sentence processing: Testing the cognitive workload of wrap-up

The current study investigated the degree to which semantic-integration processes ("wrap-up") during sentence understanding demand attentional resources by examining the effects of clause and sentence wrap-up on the parafoveal preview benefit (PPB) in younger and older adults. The PPB is defined as facilitation in processing word N + 1, based on information extracted while the eyes are fixated on word N, and is known to be reduced by processing difficulty at word N. Participants read passages in which word N occurred in a sentence-internal, clause-final, or sentence-final position, and a gaze-contingent boundary-change paradigm was used to manipulate the information available in parafoveal vision for word N + 1. Wrap-up effects were found on word N for both younger and older adults. Early-pass measures (first-fixation duration and single-fixation duration) of the PPB on word N + 1 were reduced by clause wrap-up and sentence wrap-up on word N, with similar effects for younger and older adults. However, for intermediate (gaze duration) and later-pass measures (regression-path duration, and selective regression-path duration), sentence wrap-up (but not clause wrap-up) on word N differentially reduced the PPB of word N + 1 for older adults. These findings suggest that wrap-up is demanding and may be less efficient with advancing age, resulting in a greater cognitive processing load for older readers. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Stress, Cortisol, and Externalizing Behavior in Adolescent Males: An Examination in the Context of Multisystemic Therapy

Stress and hypothalamic-pituitary-adrenal (HPA) axis dysregulation have been associated with externalizing behavior in adolescence, but few studies have examined these factors in a treatment context. This study investigated the relationship between stress, cortisol, and externalizing behavior among 120 adolescent males (mean age?=?15) receiving Multisystemic Therapy (MST). To examine the differential relationship of cortisol with various types of stressors, self-report measures assessed lifetime stress, current episodic stress, and daily hassles. Morning and afternoon cortisol samples were collected to examine whether the relationship between stress and treatment outcome depended on the youth's biological stress levels. Regression analyses indicated that awakening cortisol levels moderated the relationship between daily hassles and externalizing behaviors at post-treatment. More specifically, higher levels of daily hassles predicted worse outcomes only among adolescents with high levels of morning cortisol. In addition, lifetime stressors and afternoon measures of cortisol interacted to predict changes in caretaker reports of externalizing problems and youth arrests following treatment; lifetime stressors were positively associated with externalizing behavior when adolescents had low levels of afternoon cortisol. Implications for theory and future directions for evidence-based treatment are discussed.     

Syntactic structure building in the anterior temporal lobe during natural story listening

The neural basis of syntax is a matter of substantial debate. In particular, the inferior frontal gyrus (IFG), or Broca’s area, has been prominently linked to syntactic processing, but the anterior temporal lobe has been reported to be activated instead of IFG when manipulating the presence of syntactic structure. These findings are difficult to reconcile because they rely on different laboratory tasks which tap into distinct computations, and may only indirectly relate to natural sentence processing. Here we assessed neural correlates of syntactic structure building in natural language comprehension, free from artificial task demands. Subjects passively listened to Alice in Wonderland during functional magnetic resonance imaging and we correlated brain activity with a word-by-word measure of the amount syntactic structure analyzed. Syntactic structure building correlated with activity in the left anterior temporal lobe, but there was no evidence for a correlation between syntactic structure building and activity in inferior frontal areas. Our results suggest that the anterior temporal lobe computes syntactic structure under natural conditions.     

Childhood Social Withdrawal,Interpersonal Impairment,and Young Adult Depression: A Mediational Model

Building on interpersonal theories of depression, the current study sought to explore whether early childhood social withdrawal serves as a risk factor for depressive symptoms and diagnoses in young adulthood. The researchers hypothesized that social impairment at age 15 would mediate the association between social withdrawal at age 5 and depression by age 20. This mediational model was tested in a community sample of 702 Australian youth followed from mother’s pregnancy to youth age 20. Structural equation modeling analyses found support for a model in which childhood social withdrawal predicted adolescent social impairment, which, in turn, predicted depression in young adulthood. Additionally, gender was found to moderate the relationship between adolescent social impairment and depression in early adulthood, with females exhibiting a stronger association between social functioning and depression at the symptom and diagnostic level. This study illuminates one potential pathway from early developing social difficulties to later depressive symptoms and disorders.     

Effects of Child Psychopathology on Maternal Depression: The Mediating Role of Child-Related Acute and Chronic Stressors

In light of recent research highlighting the potential effects of children’s behavior on mothers’ mental health, the current study examined 679 mothers and their adolescent children from a community-based sample to determine the effects of youth psychopathology on maternal depression and levels of child-related stress in mothers’ lives. It was hypothesized that the number of past clinical diagnoses in 15-year-old adolescents would predict the presence of maternal depression at youth age 15 and 5 years later, as well as more episodes of maternal depression during the follow-up period. Furthermore, it was hypothesized that increased levels of child-related stress in mothers’ lives would mediate these relationships. Regression analyses indicated that past youth diagnoses do confer risk for the presence of current and future maternal depression, as well as more episodes of maternal depression, and mediation analyses revealed that child-related acute and chronic stress were mediators of the relationship between youth diagnoses and the presence of maternal depression at follow-up. Findings suggest that increased levels of child-related objective stress in mothers’ lives are one mechanism by which children’s psychopathology affects mothers’ future risk for depression.