Neuroscience and Ethics: Intersections

This essay will address the ethical issues that have emerged in the first considerations of the newly emerging stem cell technology. Many of us in the field of bioethics were deliberating related issues as we first learned of the new science and confronted the ethical issues it raised. In this essay, I will draw on the work of colleagues who were asked to reflect on early stages of the research (members of the IRBs, the Geron Ethicist Advisory Board, and the National Bioethics Advisory Commission) as the field debated the issues of consent, moral status, use of animal tissues, abortion, use of fetal tissue, and the nature and goals of entrepreneurial research. In this new capacity, ethicists weighed the problem of privacy, the role of justice considerations, and the issues of the marketplace in science. At this point, it is clear that far more issues remain unresolved than are settled, that there is largely unexplored territory ahead, and that the single most important task that faces us as a field is a steady call for ongoing conversation and public debate.     

Three-level meta-analysis of dependent effect sizes

Although dependence in effect sizes is ubiquitous, commonly used meta-analytic methods assume independent effect sizes. We describe and illustrate three-level extensions of a mixed effects meta-analytic model that accounts for various sources of dependence within and across studies, because multilevel extensions of meta-analytic models still are not well known. We also present a three-level model for the common case where, within studies, multiple effect sizes are calculated using the same sample. Whereas this approach is relatively simple and does not require imputing values for the unknown sampling covariances, it has hardly been used, and its performance has not been empirically investigated. Therefore, we set up a simulation study, showing that also in this situation, a three-level approach yields valid results: Estimates of the treatment effects and the corresponding standard errors are unbiased.     

Multicriteria Classification with Unknown Categories: A Clustering–Sorting Approach and an Application to Conflict Management

This work proposes an approach to cluster and sort a set of alternatives considering multi‐criteria categories with a partial order structure. It can be considered a heuristic approach because it does not attempt to derive an optimal partial order among all conceivable clusters of alternatives. Rather than this, it intends to be a simple approach that is transparent to the Decision Maker (DM) whose assistance is sought to help shaping the results. The approach proposed arises from the conjugation of traditional Clustering analysis and Multi‐criteria sorting tools. At the outset, the number of categories and their characteristics is unknown. First, we need to detect only the clusters themselves on the basis of a similarity measure independent of the preferences of the DM. Next, we detect potential partial order relations that might exist between them, according to the subjective preferences of the DM. Such preferences are elicited only after the DM has examined the clusters detected and deemed that these categories made sense. The new approach performs very well in a real‐world problem of management of intragroup conflicts and conflict handling strategies. Copyright © 2012 John Wiley & Sons, Ltd.     

Work Meaning Patterns in Early Career

Abstract

Work meaning patterns combine dimensions such as work centrality, expressive versus economic work goals, and entitlement versus obligation societal norms into a holistic picture of the evolution over time of the meaning of work. Data from a longitudinal study in eight countries are used to establish major work meaning patterns and to study their stability during early career paths. Further, some potential determinants of these work meaning patterns are analysed and their consequences for later careers are considered. Statistical analyses include: cluster analysis, multiple discriminant analysis, analysis of covariance combined with multiple classification analysis, analysis of variance, and chi-square analysis. Five cross-national work meaning patterns are identified for machine operators in their third year in the labour market. One-third of the sample had remained in the same work meaning pattern for 2 years, while two-thirds had changed their work pattern. Respondents' age, country, prior work environment, and prior work socialization behaviours and outcomes have an impact on work meanings held 2 years later. In addition the respondent's work meaning pattern allows subsequent career enhancing strategies and effort expenditure at the job to be predicted.     

Inattentional blindness for negative relationships in human causal learning

The present study focuses on the effect of selective attention on causal learning. Three effects of the level of attention to predictive symptoms in positive and negative contingency learning tasks are reported. First, participants accurately detected a positive relationship between an incidental cue and a contingent outcome, although judgements were slightly lower than those for the attended cue. Second, participants were unable to detect negative relationships between incidental cues and outcomes, which suggests a major role of selective attention in this type of learning. Third, participants retrieved the frequency of each trial type more accurately in the attended conditions than in the incidental conditions. These findings show how attention guides and constrains human causal learning and reveal an inattentional blindness effect for negative contingency learning.     

The Incompleteness of Theories of Games

We first state a few previously obtained results that lead to general undecidability and incompleteness theorems in axiomatized theories that range from the theory of finite sets to classical elementary analysis. Out of those results we prove several incompleteness theorems for axiomatic versions of the theory of noncooperative games with Nash equilibria; in particular, we show the existence of finite games whose equilibria cannot be proven to be computable.     

Exteroceptive control of response under delayed reinforcement

Three white rats, after 50 continuous reinforcements, were exposed successively, under dim illumination, to reinforcement delays of 1, 3, 5, 7.5, 10, 15, and 20 sec, with prolonged training at the 20-sec level. Behavior was maintained at each level, and an increase in interval was accompanied by an increase in post-reinforcement pause. Subsequently, under both 20- and 30-sec delays, the animals were tested during half of each daily session to determine the effect of introducing darkness during each delay interval. The result of this stimulus “support” was to regularize and increase response rate for each animal at both interval values.     

One size doesn’t fit all: the influence of supervisors’ power tactics and subordinates’ need for cognitive closure on burnout and stress

The present research investigated the notion of fit between supervisors’ power tactics and subordinates’ need for cognitive closure (NFCC) on subordinates’ burnout and stress. Subordinates who tend to avoid ambiguity (high NFCC) were expected to experience relatively less burnout (Study 1) and stress (Study 2) if their supervisors utilize harsh (controlling and unequivocal) power tactics and more burnout and stress if their supervisors utilize soft (autonomy-supportive and equivocal) power tactics. In contrast, it was expected that subordinates who avoid firm and binding conclusions (low NFCC) would experience relatively less burnout and stress if their supervisors use soft power tactics and more burnout and stress if they use harsh power tactics. Two studies conducted in diverse organizational settings supported these hypotheses. Collectively, these results support the conclusion that soft (vs. harsh) power tactics are not always associated with better (vs. worse) organizational outcomes. Theoretical and practical implications for organizations are discussed.