Psychosocial Factors and Disease Progression in Cancer

ABSTRACT— Psychosocial factors such as stress, personality, and social support relate to differences in disease progression in cancer patients. Neuroendocrine substances associated with psychosocial factors may regulate immune responses to cancer, as well as regulate the activity of oncogenic (cancer-causing) viruses, DNA-repair processes, and the expression in tumor cells of genes that may affect the tumor's growth and metastasis. Biobehavioral oncology research seeks to understand how these psychosocial factors, and interventions designed to modify them, become neurohormonal changes that alter cell signaling and tumor growth, viral oncogenesis, and immune responses. We review the empirical basis for psychosocial factors and biobehavioral processes in cancer progression and suggest future research.     

Stem allomorphy in the Spanish mental lexicon: evidence from behavioral and ERP experiments

This study presents results from a nonce-word elicited production task and a reading experiment using event-related brain potentials (ERPs) investigating finite forms of Spanish verbs which consist of marked stems and regular person and number agreement suffixes. The first experiment showed that unmarked stems are productively extended to nonce words, whereas marked stems generalize more restrictively to nonce words, based on lexical similarity to existing stem forms. The second experiment yielded a lexical ERP signature for stem violations and an ERP pattern signaling morpho-syntactic (rule-based) processing for suffix violations. We argue that stem allomorphy is lexically represented in the Spanish mental lexicon, with marked stems forming subnodes of structured lexical entries.     

Verhaltensmedizin bei HIV-Infektion

Zusammenfassung Unsere Studien über asymptomatische, mit dem "human immunodeficiency virus" (HIV) infizierte homosexuelle Männer zeigen, dass kognitiv-behaviorales Stressmanagement (CBSM) ein geeignetes Mittel ist, die durch die Mitteilung eines positiven HIV-Befundes verursachte psychische Belastung zu reduzieren und zugleich einige immunologische Parameter zu modifizieren. Aus neueren Studien über HIV-infizierte Männer mit Prä-Aids-Symptomatik geht hervor, dass CBSM beitragen kann: a) Dysphorie, Angst und Stresssymptome zu lindern; b) Kortisol und Noradrenalin zu reduzieren und die Testosteronwerte zu erhöhen; c) die Zahl der Antikörper gegen einige Herpes-Viren zu reduzieren und zugleich die Zahl der T-zytotoxischen/Suppressorzellen (CD8) und der naiven T-Helfer- (CD4-) Lymphozyten aufrechtzuerhalten. Vorläufige Daten unserer neuesten Studien weisen darauf hin, dass mit CBSM die Viruslast bei Männern, die hoch aktive antiretrovirale Therapie erhalten, reduziert werden kann.Aus dem Englischen übersetzt von Dipl.-Psych. Erika Nemény, Berlin und Prof. Dr. Ulrike Ehlert, Zürich     

Construct Validity of ADHD/ODD Rating Scales: Recommendations for the Evaluation of Forthcoming DSM-V ADHD/ODD Scales

Exploratory structural equation modeling (SEM) was applied to a multiple indicator (26 individual symptom ratings) by multitrait (ADHD-IN, ADHD-HI and ODD factors) by multiple source (mothers, fathers and teachers) model to test the invariance, convergent and discriminant validity of the Child and Adolescent Disruptive Behavior Inventory with 872 Thai adolescents and the ADHD Rating Scale-IV and ODD scale of the Disruptive Behavior Inventory with 1,749 Spanish children. Most of the individual ADHD/ODD symptoms showed convergent and discriminant validity with the loadings and thresholds being invariant over mothers, fathers and teachers in both samples (the three latent factor means were higher for parents than teachers). The ADHD-IN, ADHD-HI and ODD latent factors demonstrated convergent and discriminant validity between mothers and fathers within the two samples. Convergent and discriminant validity between parents and teachers for the three factors was either absent (Thai sample) or only partial (Spanish sample). The application of exploratory SEM to a multiple indicator by multitrait by multisource model should prove useful for the evaluation of the construct validity of the forthcoming DSM-V ADHD/ODD rating scales.     

Utility of the Millon Behavioral Medicine Diagnostic (MBMD) to Predict Adherence to Highly Active Antiretroviral Therapy (HAART) Medication Regimens Among HIV-Positive Men and Women

Trait loyalty has received virtually no attention from researchers; consequently, the basic goal of this research was to create a measure of interpersonal loyalty. Principal factor analyses of an initial pool of items revealed 2 factors: Individual Loyalty (e.g., “I stand by my friends, even when they make mistakes”) and Group Loyalty (e.g., “I am loyal to my country”). Analyses of a revised item pool identified the same 2 factors in a second sample. Scales based on these factors were internally consistent and only moderately related to one another. Additional analyses indicated that both scales (a) were stable over time; (b) showed moderate to strong self-peer agreement; (c) positively correlated with conscientiousness, agreeableness, altruism, and positive emotionality; and (d) negatively related to an avoidant attachment style. However, these associations all were moderate in magnitude (in fact, none was as high as |.40|), indicating that the Individual and Group Loyalty Scales tap unique variance that is not captured by existing instruments.     

Research note: A motivational perspective on change processes and outcomes

A reengineering process in a chemical plant with technostructural and human-process-oriented interventions was analysed in order to develop and test a generalized expectancy?–?valence-theory model for participation in the change process and effective change. It was assumed that both supervisory support and favourable colleagues' change attitudes enhance one's change motivation, and participation in the change process, by increasing participation opportunities, and positive attitudes toward change. In turn, employee participation should have a positive impact on outcomes of the change process. After 2 years of restructuring, 104 employees participated in the evaluation of the change process. Path analyses revealed results that supported our model by and large. Employee participation in the change process predicts positive organizational effects. Favourable change attitudes as well as perceived participation opportunities, and supervisory support, which were integrated into one scale, predict the degree of employee participation. The latter also showed a direct path to organizational effects.     

The Factor Structure and Reliability of a Six-Item Sense of Coherence Measure

The study investigated the factor structure and reliability of a six-item sense of coherence (SOC) measure. Participants were a South African white collar employee sample (n=7185) purposively selected from over 300 different companies across various business sectors. The sample constituted 34% male and 66% female and 34% Black, 18% Coloured, 11% Indian and 37% White employees. Exploratory factor analysis (EFA) was used for the structural analysis. The reliability of the scores was also estimated. A unidimensional structure seemed to best represent the six-item SOC measure. The internal reliability of the scores from the measure was high.     

Coping among african-american,hispanic, and non-hispanic white women recently treated for early stage breast cancer

Relatively little is known about how members of minority groups cope with experiences such as diagnosis and treatment of breast cancer – in particular, whether coping patterns among minorities differ from that of the majority. This study adds to the existing knowledge base using a cross-sectional sample of middle-class African-American (n = 26), Hispanic (n = 59), and non-Hispanic White women (n = 151) who had been treated for early stage breast cancer in the past year. We tested for differences in coping responses per se and also for the possibility that coping would relate to distress differently in different groups. There were only two differences in coping (controlling for medical variables, education, and distress): compared to non-Hispanic White women, the other two groups both reported using humor-based coping less, and religion-based coping more. There was one difference in how coping related to distress: venting related more strongly to elevated distress among Hispanic than among non-Hispanics. Discussion centers on a growing consensus on ethnic differences in religious and humor-based coping, and on the relative absence of other coping differences among these populations.     

Utility of the Millon Behavioral Medicine Diagnostic to Predict Medication Adherence in Patients Diagnosed with Heart Failure

Medication non-adherence is common and a primary reason for poor medical outcomes among individuals with heart failure (HF). This study's aims were to determine whether depression, hostility, and the personality-based Millon Behavioral Medicine Diagnostic (MBMD) Medication Abuse scale were associated with medication adherence (e.g., beta-blockers, ACE inhibitors, diuretics, statins) beyond contributions of demographic, medical, and psychosocial variables in an ethnically-diverse sample of 105 men and women diagnosed with HF. In hierarchical regression, greater MBMD Medication Abuse scale scores were associated with poorer adherence above and beyond both depression (β?=?.236, t[102]?=?2.113, p?=?.037) and hostility (β?=?.244, t[102]?=?2.506, p?=?.014). The Medication Abuse scale also completely mediated the relationship between adherence and depression. These findings suggest that personality measures such as the MBMD and hostility scales might be utilized in future studies investigating predictors of adherence and also used clinically to predict medication adherence among HF patients.