Neuropsychological Functioning in Children with Medium Chain Acyl Coenzyme A Dehydrogenase Deficiency (MCADD): The Impact of Early Diagnosis and Screening on Outcome

Children with medium chain acyl coenzyme A dehydrogenase deficiency (MCADD) have been reported to be at high risk for neurocognitive deficits. However this has not been systematically studied and little is known about the exact nature of neuropsychological sequelae or of the impact of early diagnosis and screening on outcome. We examined cognitive and adaptive outcome in children with MCADD (N?=?38, age range: 2 years, 2 months – 10 years, 3 months) diagnosed either through a newborn screening program (tandem mass spectrometry/MSMS) or upon clinical presentation. There was no evidence of overall intellectual impairment in either groups but there was some suggestion of poorer verbal and specific executive functioning (i.e., planning) abilities in the unscreened cohorts. Adaptive functioning was relatively intact with the exception of reduced Daily Living Skills in both our screened and unscreened groups. Early diagnosis and greater number of hospitalizations were related to higher verbal, communication, and socialization skills. Overall, our results highlight the importance of early diagnosis and management for children with MCADD.     

Who are maximizers? Future oriented and highly numerate individuals

Two studies investigated cognitive mechanisms that may be associated with people's tendency to maximize. Maximizers are individuals who are spending a great amount of effort in order to find the very best option in a decision situation, rather than stopping the decision process when they encounter a satisfying option. These studies show that maximizers are more future oriented than other people, which may motivate them to invest the extra energy into optimal choices. Maximizers also have higher numerical skills, possibly facilitating the cognitive processes involved with decision trade‐offs.     

Effects of self-generated versus experimenter-provided cues on the representation of future events

Most experimental studies of prospection focused on episodic forms of future events prompted by means of verbal cues. However, there is evidence suggesting that future events differ considerably according to whether they are produced in response to external, experimenter-provided verbal cues or they are self-generated. In the present study, we compared the quality, the phenomenal characteristics, the temporal distribution, and the content of imagined events prompted by experimenter-provided cues (i.e., cue-words and short verbal sentences) or elicited by means of verbal cues that were self-generated in an autobiographical fluency task. The results showed that future events prompted by means of self-generated cues contained fewer event-specific details than future events prompted by experimenter-provided cues. However, future events elicited by means of self-generated and by experimenter-provided cues did not differ with respect to their phenomenal characteristics. The temporal distribution and the thematic content of future representations were also affected by the type of cue used to elicit prospection. These results offer a holistic view of the properties of future thinking and suggest that the content and the characteristics of envisioned future events may be affected by the method used to elicit prospection.     

Automatic Associations and Conscious Attitudes Predict Different Aspects of Men’s Intimate Partner Violence and Sexual Harassment Proclivities

Intimate partner violence against women (IPV) and sexual harassment are both widespread. Research on their causes and attitudinal correlates has rarely examined implicit, automatic cognitive associations related to the partner (in IPV aggressors) or to women (in sexual harassment offenders). The aim of the present research was to study these implicit associations in 129 male German students. Participants completed scales of hostile sexism (HS), masculine gender role stress (MGRS), short-term (STMO) and long-term mating orientation (LTMO), and proclivity to both IPV and sexual harassment. Next they performed a primed lexical decision task that measured whether concepts of violence, power, hostility, and sexuality were differentially associated with representations of women, men, and the participant’s own intimate partner. Results showed that implicit associations of own partner with violence as well as hostility were generally high but did not correlate strongly with the proclivity measures. Furthermore, the proclivity measures were positively predicted by HS, MGRS, and STMO, whereas LTMO negatively predicted IPV proclivity. Practice implications point to the need to address early socialization processes that may shape men’s negative associations with female partners. Some strategies to prevent and reduce these types of implicit associations are discussed.

     

Motives to Report Stalking Cases to the Police: A Comparison Between a Large City and a Small Town in Italy

This study aimed to analyze the cases reported to police by women who were victims of stalking. The use of police offense records is well known in investigations of victims of this phenomenon as well as other violent crimes (e.g., domestic violence). The objective was to compare the 3 motives (own safety, other safety, change habits) indicated by victims in reporting the cases to police as recorded in case files. For each motive, a comparison was made of the characteristics of victims and stalkers, the nature of the relationship between the victims and stalkers, and the characteristics of the stalking campaign, the stalker’s behaviors, the consequences to the victims, and coping strategies. This information was reported by victims to police in a large city and small town in Italy. The comparison showed that victims in large cities were less prone to report stalking cases to the police than victims in small towns. Differences addressed the duration of the stalking campaign, the behaviors involved, the consequences, and the coping strategies adopted. Police forces could benefit from the results of this research in defining both training courses for police officers and prevention courses for the general population.     

The Drive For Self-Assertion And The Reality Principle In A Patient With Malignant Pleural Mesothelioma: The History of Giulia*

Life in a contaminated environment is often marked by a cumulative psychological trauma that exhibits a variety of social-environmental aspects. This is why I suggested a psychotherapeutic group intervention for the population of Casale Monferrato, a municipality in Northern Italy that is sadly renowned for asbestos-related events and the high mortality rate of its inhabitants. Groupality appears to show the point of contact between psyche and soma, while also promoting the birth of a more realistic approach to the various levels of suffering and their configuration. The multifamily approach seemed to be the most adequate to elaborate the feelings of rage and fear that are concurrent with the aerial contagion. In the “long wave” of group work we have learned to work with participants as well as with empty chairs, the ghosts of the dead: live traces in the mind. Whereas the mind recovers the possibility of entering into a dialogue with the feelings connected to the trauma, without bypassing them towards actions that are apparently more assertive of one’s sense of Ego, the will of conciliation can reactivate a thought that is oriented towards the plane of reality.     

Life Satisfaction,Sense of Coherence and Job Precariousness in Italian Young Adults

We investigated (in 95 Italians aged 19–29, of both genders, and who were all facing the transition to job): (1) the relationships between job precariousness, life satisfaction (LS), and the perception that the reality is comprehensible, manageable and meaningful (sense of coherence—SOC—Antonovsky 1987); (2) the potential buffering effect of SOC versus job precariousness on LS. The findings showed that (a) young adults with a higher level of education perceive less LS and higher manageability, and youths with a precarious job perceive reality as less controllable, manageable and meaningful; (b) manageability is positively related with satisfaction with close relationships and meaningfulness is positively related with LS in general; (c) meaningfulness also buffers the effect of job precariousness on satisfaction for close relationships; among precarious workers there is a curvilinear relationship with LS: youths with intermediate meaningfulness also show higher LS with respect to both low and high meaningfulness.     

Personality, event-related potential (ERP) and heart rate (HR): An investigation of Gray's theory

Following Gray's theory of personality, the aim of the study was to examine the role of the personality dimensions, behavioural inhibition and activation, in mediating event-related potentials (ERPs) and the level of anticipatory heart rate (HR) deceleration response during two visual-stimulus recognition tasks. In the first task ERPs and anticipatory HR changes were elicited by feedback words informing the subjects about the quality of their response (‘correct’, ‘incorrect’). In the second task ERPs and HR responses were elicited from 62 women by feedback words (‘losing’, ‘winning’) indicating losing or winning, of amounts of money. The Gray-Wilson Personality Questionnaire (GWPQ), the Eysenck Personality Questionnaire (EPQ) and the I₇ questionnaire were used to measure variables which refer to the function of the activation and inhibition system. The N200, P300, N400, P650 and N800 peak amplitudes of the ERPs and the level of anticipatory HR deceleration response to the feedback signals were measured. Personality and physiological responses were first analysed by using a split-plot ANOVA design and second by examining multiple relationships with factor analysis. Separate ANOVAs were performed across Ss selected from the total group (n = 62) on the basis of extreme scores (high or low) on Approach (APPR), Passive Avoidance (PASS.AV), Extinction (EXTI), Extraversion (E), Neuroticism (N) and Impulsiveness (I). In line with Gray's prediction, high APPR Ss exhibited larger P600 peak amplitudes to signals indicating winning and low APPR Ss exhibited larger P600 amplitudes to signals indicating losing. Neurotic Ss produced larger N800 peak amplitudes to stimuli indicating losing as compared with stimuli indicating winning. Stable Ss, in contrast, did not display differences between feedback stimuli. Heart-rate deceleration response to feedback signals was successful in distinguishing high and low N Ss as well as Introverts and Extraverts. Neurotic Ss, compared with Stable ones, showed a more pronounced anticipatory HR slowing for both of the feedback signals. Introverts displayed more pronounced HR decelerations for punishment compared with reward signals. Extraverts, in contrast, showed greater HR decelerations for reward compared with punishment signals. These results were all in line with predictions that can be derived from Gray's theory. However, in the opposite direction was the relationship between PASS.AV and N200 peak: High PASS.AV Ss displayed greater N200 peak amplitudes to winning signals compared with signals indicating a correct response. Results from factor analysis gave rise to a three-factor solution wherein personality dimensions sensitive to signals of reward and that sensitive to signals of punishment were loading together with different physiological factors.