Nanomedicine: Building a Bridge Between Science and Law

This article aims to address challenges of translating emerging scientific technologies into legal terms and incorporate them into the existing North American regulatory regimes. A lack of full scientific knowledge about nanomedicine technologies results in the lack of development in legal discourse to describe products and to clearly set legal standards on their safety and efficacy. The increasing complexity and hybrid nature of technologies negatively impact the functionality of “law in action” leading to a legal uncertainty and ultimately to a public distrust. Nanomedicine is an illustrative example of how law lags behind increasingly fast-paced scientific technologies making it difficult to find a balance between innovation and safety. This article argues that the boundary crossing nature of nanomedicine through different domains of science triggers a methodological and epistemological debate within science and law, suggesting that a critical revision is required in our traditional methods to learn, create, and categorize knowledge from breakthrough scientific advances. The highly disruptive nature of nanomedicine places stress on traditional conceptual frameworks, classifications of knowledge, and existing regulations. The legal challenge to identify definitions or to classify nanoapplications brings to light a conceptual vacuum surrounding nanomedicine. Moving away from confusing policies and obsolete classificatory models, this article suggests to undertake changes that are only the first steps of a more in-depth “epistemological transformation” that addresses knowledge as the process of not only gathering data, but also, as the process of elaborating new conceptual bases to better fulfill the legal language and facilitate the legal task of finding definitions and formulating criteria more adherent with scientific advances. This should compel regulators to explore new paradigms and develop new methodologies to evaluate data on nanomedicine applications in order to provide sustainable bases for a responsible development of nanomedicine.     

Enhancing theory of mind in behavioural variant frontotemporal dementia with transcranial direct current stimulation

Behavioural variant frontotemporal dementia (bvFTD) is a form of frontotemporal degeneration characterized by early changes in personality, emotional blunting, and/or loss of empathy. Recent research has highlighted that these features may be at least partially explained by impairments in the theory of mind (ToM; i.e., the ability to understand and predict other people’s behaviour by attributing independent mental states to them). The aim of this randomized, double-blind, placebo-controlled study was to test the hypothesis that transcranial direct current stimulation (tDCS) over the medial frontal cortex (MFC) selectively enhances communicative intention processing, a specific ToM ability. Using a single-session online design, we administered a ToM task that measures the ability to represent other people’s private and communicative intentions during active or sham tDCS to 16 bvFTD patients. To assess the impact of dementia on performance on the ToM task, we included 16 age-matched healthy volunteers who were asked to perform the entire experimental ToM task. BvFTD is characterized by an impairment in the comprehension of both communicative and private intentions relative to a healthy control group and by a disproportional impairment in communicative intention compared with private intention processing. Significant and selective accuracy improvement in the comprehension of communicative intentions after active stimulation was observed in patients with bvFTD. This is the first study that analyses ToM ability in patients with bvFTD using tDCS stimulation. Our findings could potentially contribute to the development of an effective, noninvasive brain stimulation treatment of ToM impairments in patients with bvFTD.     

Only your eyes tell me what you like: Exploring the liking effect induced by other's gaze

Our preferences are sensitive to social influences. For instance, we like more the objects that are looked-at by others than non-looked-at objects. Here, we explored this liking effect, using a modified paradigm of attention cueing by gaze. First, we investigated if the liking effect induced by gaze relied on motoric representations of the target object by testing if the liking effect could be observed for non-manipulable (alphanumeric characters) as well as for manipulable items (common tools). We found a significant liking effect for the alphanumeric items. Second, we tested if another type of powerful social cue could also induce a liking effect. We used an equivalent paradigm but with pointing hands instead of gaze cues. Pointing hands elicited a robust attention-orienting effect, but they did not induce any significant liking effect. This study extends previous findings and reinforces the view of eye gaze as a special cue in human interactions.     

Neuropsychological Functioning in Children with Medium Chain Acyl Coenzyme A Dehydrogenase Deficiency (MCADD): The Impact of Early Diagnosis and Screening on Outcome

Children with medium chain acyl coenzyme A dehydrogenase deficiency (MCADD) have been reported to be at high risk for neurocognitive deficits. However this has not been systematically studied and little is known about the exact nature of neuropsychological sequelae or of the impact of early diagnosis and screening on outcome. We examined cognitive and adaptive outcome in children with MCADD (N?=?38, age range: 2 years, 2 months – 10 years, 3 months) diagnosed either through a newborn screening program (tandem mass spectrometry/MSMS) or upon clinical presentation. There was no evidence of overall intellectual impairment in either groups but there was some suggestion of poorer verbal and specific executive functioning (i.e., planning) abilities in the unscreened cohorts. Adaptive functioning was relatively intact with the exception of reduced Daily Living Skills in both our screened and unscreened groups. Early diagnosis and greater number of hospitalizations were related to higher verbal, communication, and socialization skills. Overall, our results highlight the importance of early diagnosis and management for children with MCADD.     

A device for facilitating the computation of the first four moments about the mean

A mechanical device is described which materially reduces the time, labor, and probability of errors which are involved in the computation of certain moments about the mean. The use of the device is illustrated with the computation of the mean, standard deviation,g ₁ as a measure of skewness, andg ₂ as a measure of kurtosis of data from a given study.Grateful acknowledgment is made to the Holter Research Foundation of Helena, Montana for the grant-in-aid which made possible the development of this device.     

Who are maximizers? Future oriented and highly numerate individuals

Two studies investigated cognitive mechanisms that may be associated with people's tendency to maximize. Maximizers are individuals who are spending a great amount of effort in order to find the very best option in a decision situation, rather than stopping the decision process when they encounter a satisfying option. These studies show that maximizers are more future oriented than other people, which may motivate them to invest the extra energy into optimal choices. Maximizers also have higher numerical skills, possibly facilitating the cognitive processes involved with decision trade‐offs.     

Effects of self-generated versus experimenter-provided cues on the representation of future events

Most experimental studies of prospection focused on episodic forms of future events prompted by means of verbal cues. However, there is evidence suggesting that future events differ considerably according to whether they are produced in response to external, experimenter-provided verbal cues or they are self-generated. In the present study, we compared the quality, the phenomenal characteristics, the temporal distribution, and the content of imagined events prompted by experimenter-provided cues (i.e., cue-words and short verbal sentences) or elicited by means of verbal cues that were self-generated in an autobiographical fluency task. The results showed that future events prompted by means of self-generated cues contained fewer event-specific details than future events prompted by experimenter-provided cues. However, future events elicited by means of self-generated and by experimenter-provided cues did not differ with respect to their phenomenal characteristics. The temporal distribution and the thematic content of future representations were also affected by the type of cue used to elicit prospection. These results offer a holistic view of the properties of future thinking and suggest that the content and the characteristics of envisioned future events may be affected by the method used to elicit prospection.     

Automatic Associations and Conscious Attitudes Predict Different Aspects of Men’s Intimate Partner Violence and Sexual Harassment Proclivities

Intimate partner violence against women (IPV) and sexual harassment are both widespread. Research on their causes and attitudinal correlates has rarely examined implicit, automatic cognitive associations related to the partner (in IPV aggressors) or to women (in sexual harassment offenders). The aim of the present research was to study these implicit associations in 129 male German students. Participants completed scales of hostile sexism (HS), masculine gender role stress (MGRS), short-term (STMO) and long-term mating orientation (LTMO), and proclivity to both IPV and sexual harassment. Next they performed a primed lexical decision task that measured whether concepts of violence, power, hostility, and sexuality were differentially associated with representations of women, men, and the participant’s own intimate partner. Results showed that implicit associations of own partner with violence as well as hostility were generally high but did not correlate strongly with the proclivity measures. Furthermore, the proclivity measures were positively predicted by HS, MGRS, and STMO, whereas LTMO negatively predicted IPV proclivity. Practice implications point to the need to address early socialization processes that may shape men’s negative associations with female partners. Some strategies to prevent and reduce these types of implicit associations are discussed.

     

Motives to Report Stalking Cases to the Police: A Comparison Between a Large City and a Small Town in Italy

This study aimed to analyze the cases reported to police by women who were victims of stalking. The use of police offense records is well known in investigations of victims of this phenomenon as well as other violent crimes (e.g., domestic violence). The objective was to compare the 3 motives (own safety, other safety, change habits) indicated by victims in reporting the cases to police as recorded in case files. For each motive, a comparison was made of the characteristics of victims and stalkers, the nature of the relationship between the victims and stalkers, and the characteristics of the stalking campaign, the stalker’s behaviors, the consequences to the victims, and coping strategies. This information was reported by victims to police in a large city and small town in Italy. The comparison showed that victims in large cities were less prone to report stalking cases to the police than victims in small towns. Differences addressed the duration of the stalking campaign, the behaviors involved, the consequences, and the coping strategies adopted. Police forces could benefit from the results of this research in defining both training courses for police officers and prevention courses for the general population.