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211.
Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain
Giménez-Llort L Schiffmann SN Shmidt T Canela L Camón L Wassholm M Canals M Terasmaa A Fernández-Teruel A Tobeña A Popova E Ferré S Agnati L Ciruela F Martínez E Scheel-Kruger J Lluis C Franco R Fuxe K Bader M 《Neurobiology of learning and memory》2007,87(1):42-56
Adenosine receptors in the central nervous system have been implicated in the modulation of different behavioural patterns and cognitive functions although the specific role of A(2A) receptor (A(2A)R) subtype in learning and memory is still unclear. In the present work we establish a novel transgenic rat strain, TGR(NSEhA2A), overexpressing adenosine A(2A)Rs mainly in the cerebral cortex, the hippocampal formation, and the cerebellum. Thereafter, we explore the relevance of this A(2A)Rs overexpression for learning and memory function. Animals were behaviourally assessed in several learning and memory tasks (6-arms radial tunnel maze, T-maze, object recognition, and several Morris water maze paradigms) and other tests for spontaneous motor activity (open field, hexagonal tunnel maze) and anxiety (plus maze) as modification of these behaviours may interfere with the assessment of cognitive function. Neither motor performance and emotional/anxious-like behaviours were altered by overexpression of A(2A)Rs. TGR(NSEhA2A) showed normal hippocampal-dependent learning of spatial reference memory. However, they presented working memory deficits as detected by performance of constant errors in the blind arms of the 6 arm radial tunnel maze, reduced recognition of a novel object and a lack of learning improvement over four trials on the same day which was not observed over consecutive days in a repeated acquisition paradigm in the Morris water maze. Given the interdependence between adenosinic and dopaminergic function, the present results render the novel TGR(NSEhA2A) as a putative animal model for the working memory deficits and cognitive disruptions related to overstimulation of cortical A(2A)Rs or to dopaminergic prefrontal dysfunction as seen in schizophrenic or Parkinson's disease patients. 相似文献
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Prof. Dr. Werner Laubichler Prof. Dr. Anton Kühberger 《Forensische Psychiatrie, Psychologie, Kriminologie》2009,3(4):309-317
We collected data on 121 cases of homicide and manslaughter in the normal penitentiary system and counted the cases of perpetrators with, and without, psychiatric diagnosis. About 30% of the sample consisted in perpetrators without any psychiatric diagnosis; in contrast, about 40% were diagnosed as personality disorder; some few cases (7%) were classified as alcoholism or polytoxicomania, respectively; and the rest (23%) were cases of both personality disorder and alcoholism/polytoxicomania. Perpetrators without psychiatric diagnosis differed in systematic ways from perpetrators with psychiatric diagnosis. The former committed their offenses more on victims in partnership and family, while perpetrators with psychiatric diagnosis frequently offended strangers. Perpetrators lacking a diagnosis used poison, and striking to dead, relatively more frequently while homicide and manslaughter by stabbing, shooting, or some combination thereof were committed mainly by perpetrators with psychiatric diagnosis. Diagnosed perpetrators had more frequently been previously convicted (nearly 70%). In sum we found a considerable percentage of perpetrators who lacked a psychiatric diagnosis. We argue that this group can properly be distinguished from perpetrators who have some psychiatric diagnosis. 相似文献
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Philosophical Studies - Peter Singer’s defense of the duty to aid the world’s poor by the pond analogy is self-defeating. It cannot be both true that you ought to save the drowning... 相似文献
214.
Joo Batista Joana Silva Carina Magalhes Helena Ferreira Pablo Fernndez‐Navarro Miguel M. Gonalves 《Counselling and Psychotherapy Research》2020,20(3):442-448
This paper aims to describe the Innovative Moments (IM) Coding System (IMCS), an idiographic and transtheoretical methodology that allows the identification of IMs—markers of changes in the client's initial maladaptive framework of meaning—throughout psychotherapy. The present study introduces the theoretical background underlying this methodology, along with the main empirical findings resulting from former studies that have applied this tool to clinical data. The IMCS application is also detailed: the coding phases, the training steps and inter‐rater agreement measures. In order to illustrate the application of IM coding, a case study is presented. Although a partial coding was used, the results are in line with previous research. Discussion is centred on the usefulness of the IMCS for the advance of process research in psychotherapy, and the potential use of this methodology in group format. 相似文献
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Empirical research on counterfactual thinking has found a closeness effect: people report higher negative affect if an actual outcome is close to a better counterfactual outcome. However, it remains unclear what actually is a “close” miss. In three experiments that manipulate close counterfactuals, closeness effects were found only when closeness was unambiguously defined either with respect to a contrasted alternative, or with respect to a categorical boundary. In a real task people failed to report greater negative affect when encountering a close numerical miss, while they predicted greater negative affect hypothetically. These results show that counterfactual closeness effects on affect depend on closeness being accessible and unambiguously defined. 相似文献
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N‐Methyl‐D ‐aspartate (NMDA) receptor antagonists are perspective candidates for medication development for a number of diseases/states that are associated with increased aggressiveness (e.g., opioid withdrawal). The prototypic NMDA receptor antagonist phencyclidine (PCP) itself is a widely abused substance and is known to elevate levels of aggression in drug users. The present study was aimed at testing several drugs that share with PCP the ability to block NMDA receptor–associated channel. The resident‐intruder procedure was used to assess drug effects on aggressive behavior in isolated male mice. Resident aggressive mice were administered NMDA channel blockers (PCP; 0.3–10 mg/kg), dizocilpine (MK‐801; 0.01–0.3 mg/kg), memantine (1–30 mg/kg), and MRZ 2/579 (0.1–5.6 mg/kg). The competitive NMDA receptor antagonist D CPPene (0.1–5.6 mg/kg) was also tested as a compound representing an alternative approach to reduce activity of NMDA receptor complex. PCP, dizocilpine, and memantine inhibited expression of aggressive behaviors only at doses that produced ataxia. The novel channel blocker MRZ 2/579 also produced ataxia at the highest dose level but failed to affect aggressiveness. Reduction in aggression with a corresponding increase in sociability was observed after administration of D ‐CPPene. Overall, the present results suggest that NMDA receptor channel blockers do not exert selective effects on aggressive behavior. Aggr. Behav. 25:381–396, 1999. © 1999 Wiley‐Liss, Inc. 相似文献
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