The Importance of Written Information Packages in Support of Case-Finding Within Families at Risk for Inherited High Cholesterol

Inherited High Cholesterol is treatable, but highly underdiagnosed. To detect undiagnosed blood relatives at a presymptomatic stage, in the Netherlands written information packages are available to facilitate family communication. To investigate the role of those packages in the detection of carriers, we conducted a qualitative evaluation (plus-minus method combined with semistructured interviews with index patients and relatives). Our data suggest that interviewees approved the family approach for finding carriers, although reluctantly. The packages aided family disclosure by reducing hesitation. However, index patients only informed first-degree relatives and generally communicated the risk only once. This may be due to the cultural context and a limited understanding of genetics. For relatives the packages served as a cue to action and as a legitimation to gain access to a diagnostic cholesterol test. Despite the value of these written materials, they should not be used as the only communication between index patient and relatives.     

Effects of subchronic administration of gammahydroxybutyrate (GHB) on spatial working memory in rats

GHB, a popularly known drug as "liquid ecstasy", is a substance with abuse potential. Among the possible described side-effects after the continued consumption of GHB are amnesia and deterioration of memory. Likewise, recent studies indicate the existence of neurotoxicity in certain brain regions after its prolonged treatment. The aim of this study was to examine the effect of the subchronic administration of GHB (10 and 100 mg/kg) on spatial memory and sensoriomotor reflexes in male rats, using the Morris water maze and a battery of sensoriomotor tests, respectively. The results indicated that animals treated with GHB (10 mg/kg) showed a greater latency of escape during the phase of acquisition in the days first and third of tests, as compared with the control group (p<0.05), as well as a deterioration of grasping reflex with the two doses of GHB (p<0.01). Numerous studies indicated that the medial prefrontal cortex is a crucial neuronal substrate in the working memory and grasping reflex modulation. These results suggest that prolonged administration of GHB could alter structure and/or function of the medial prefrontal cortex, as well as its interconnections with other brain regions involved in the evaluated cognitive and neurological processes.     

Schizotypy and verbal memory in the adolescent general population

The following study examines the relationship between verbal memory deficits and schizotypal traits measured psychometrically from a non- clinical adolescent population. In this transversal analytical study participated 139 subjects. They were secondary school students, with ages ranging from 13 to 16 years old (mean= 14, 35; Sta.Dev.= 0, 548). After administrating the scales O-LIFE (psychometrical schizotypy), CVLT (verbal memory), and Letters and Numbers subtest of WAIS-III (working memory), data was analyzed utilizing Pearson correlations and mean comparison test. Results showed lack of relations between schizotypy measures and working memory. Nonetheless, some of the O-LIFE dimensions correlated with verbal memory. These findings support partly the literature reviewed. Yet, more work focused on schizotypy and cognitive deficits as risk factors are suggested.     

Achievement goals and engagement in individual and collective learning activities

The relationship between achievement goals and individual and collective learning activities was examined for 290 university students who completed two questionnaires. One assessed three achievement goals-a mastery goal and two performance goals, namely, approval seeking and advancing. The other questionnaire measured how actively students report engaging in individual and collective learning activities. Regression analyses showed that the adoption of mastery goals was associated with active engagement in both individual and collective learning, while adoption of a performance goal of approval seeking was associated with passive engagement in individual learning activities. These results are discussed in relation to their theoretical implications and in regard to the possible moderating effect of protecting self-worth.     

Do obsessional beliefs discriminate OCD without tic patients from OCD with tic and Tourette's syndrome patients?

There is considerable overlap in symptomatology between Tourette's syndrome (TS) and obsessive-compulsive disorder (OCD). Increased rates of tics are found in OCD and up to 60% obsessive-compulsive symptoms in TS. However, in OCD obsessive-compulsive symptoms are more often anxiety-related and, as a consequence, aimed at anxiety-reduction, whereas in TS these symptoms are more stimulus-bound. Therefore, it is of clinical interest to study whether these phenomenological differences are reflected in differences between dysfunctional cognitions accompanying OC symptoms in OCD with or without tics and TS. Current cognitive theory of OCD ascertains that specific dysfunctional beliefs are important in the etiology and maintenance of OCD. To assess these beliefs, the obsessive-compulsive beliefs questionnaire-87 (OBQ-87) has been developed. In the present study, OBQ-87 scores of OCD patients without tics, OCD with tics, and TS (without OCD) patients were compared to those of normal controls. Results: OCD without tic patients exhibited higher OBQ-87 scores than TS patients. No differences were found between OCD with or without tic patients on any of the OBQ-87 subscales. These results suggest that: (1) dysfunctional beliefs have no discriminative power with respect to OCD with or without tic patients; (2) the direct relationship between types of OC symptoms and specific dysfunctional beliefs is questionable. Therefore, one can doubt the specificity of cognitive theory of OCD to explain specific OC behavior.     

The Miandad effect reconsidered: analysis of Pakistan's cricket performance 1952 to 2005

In 2004 Abbasi and Khan reported an enduring influence of a 1986 Pakistani landmark victory in cricket over India on subsequent matches up to 2003. The present study reconsidered the significance and the specificity of this phenomenon, denoted as the "Miandad effect." All 659 Pakistani cricket encounters with India and other frequently played opponents up to 2005 which yielded a winning team were included in the analysis. The increase in matches won by Pakistan over India in the post-1986 period was statistically not significant. Changes in match performance against other frequently played nations, namely, increases against England and the West Indies as well as decreases against Australia and Sri Lanka, were larger than the one seen with India. Apparently, the Miandad effect neither generalized to all recurrently encountered opponents, nor was specific to India.     

Comparability, reliability, and practice effects on alternate forms of the Digit Symbol Substitution and Symbol Digit Modalities tests

The present study examined the comparability of 4 alternate forms of the Digit Symbol Substitution test and the Symbol Digit Modalities (written) test, including the original versions. Male contact-sport athletes (N = 112) were assessed on 1 of the 4 forms of each test. Reasonable alternate form comparability was demonstrated through establishing normality of form distributions and conducting pairwise form comparisons of means, variability, and intraclass correlations. Nonetheless, alternate forms are likely an insufficient means of controlling practice in speeded measures at brief (1-2 weeks) retest intervals. Reliable change indices demonstrated that practice must be accounted for in individual retesting.     

Moral psychology of nursing robots: Exploring the role of robots in dilemmas of patient autonomy

Artificial intelligences (AIs) are widely used in tasks ranging from transportation to healthcare and military, but it is not yet known how people prefer them to act in ethically difficult situations. In five studies (an anthropological field study, n = 30, and four experiments, total n = 2150), we presented people with vignettes where a human or an advanced robot nurse is ordered by a doctor to forcefully medicate an unwilling patient. Participants were more accepting of a human nurse's than a robot nurse's forceful medication of the patient, and more accepting of (human or robot) nurses who respected patient autonomy rather than those that followed the orders to forcefully medicate (Study 2). The findings were robust against the perceived competence of the robot (Study 3), moral luck (whether the patient lived or died afterwards; Study 4), and command chain effects (Study 5; fully automated supervision or not). Thus, people prefer robots capable of disobeying orders in favour of abstract moral principles like valuing personal autonomy. Our studies fit in a new era in research, where moral psychological phenomena no longer reflect only interactions between people, but between people and autonomous AIs.     

Emotional Reactions to People With AIDS

Using survey data of a Dutch national sample, the present paper examines how people's willingness to engage in personal contact with persons with AIDS (PWAs) is influenced by different emotional reactions to PWAs. Results indicate that each of the three measured emotional reactions to PWAs (fear, irritation, and pity) independently predicts subjects' readiness to have personal contact with PWAs. Disconfirming the often assumed relationship between "homophobia" and fear of PWAs, it was found that attitudes toward homosexuals are unrelated to fear of PWAs. Instead, these attitudes are associated with emotions of a more aggressive nature (irritation). Risk perception seems to be related to the emotions of fear and irritation, whereas responsibility attribution seems to be negatively associated with pity.