The ethical and legal aspects of palliative sedation in severely brain-injured patients: a French perspective

The 2011 Varsity Medical Debate, between Oxford and Cambridge Universities, brought students and faculty together to discuss the waiving of patents for antiretroviral therapies in the developing world. With an estimated 29.5 million infected by Human Immunodeficiency Virus (HIV) in low- and middle-income countries and only 5.3 million of those being treated, the effective and equitable distribution of anti-retroviral therapy (ART) is an issue of great importance. The debate centred around three areas of contention. Firstly, there was disagreement about whether patents were the real barrier to the access of anti-retroviral therapy in the developing world. Secondly, there were differing views on the effectiveness of a patent pool. Thirdly, concerns were raised over the impact of waiving patents on research to produce new and better anti retro-viral drugs.     

Sustained withdrawal behavior in clinic‐referred and nonreferred infants

To examine the relations between infants' sustained withdrawal behavior and children's mental health status and maternal and child relational behavior, 36 clinic‐referred and 43 control infants were evaluated. Families were visited at home, mother‐child free play and feeding interactions were videotaped, and mothers completed self‐report measures. Interactions were coded for sustained withdrawal using the Alarm Distress Baby Scale (ADBB; Guedeney and Fermanian, 2001) and for global relational patterns with the Coding of Interactive Behavior (CIB; Feldman, 1998). Higher ADBB scores were found for the referred group, with many infants (38.9% ) scoring above the clinical cutoff (vs. 11.6% in the control group). More negative relational patterns were found for the withdrawn group in terms of higher maternal intrusiveness, lower reciprocity, and lower child involvement. Associations were found between maternal and child behavior during play and feeding and child sustained withdrawal behavior at play. Sustained withdrawal also was associated with unpredictable child temperament and lower sense of parental self‐efficacy. Maternal depressive symptoms were higher in the referred group and correlated with maternal and child relational patterns. The findings contribute to the construct and discriminant validity of the CIB and the ADBB coding systems, and suggest that sustained withdrawal may serve as a risk indicator for early socioemotional disorders.     

Toward a neurophenomenology as an account of generative passages: a first empirical case study

This paper analyzes an explicit instantiation of the program of neurophenomenology in a neuroscientific protocol. Neurophenomenology takes seriously the importance of linking the scientific study of consciousness to the careful examination of experience with a specific first-person methodology. My first claim is that such strategy is a fruitful heuristic because it produces new data and illuminates their relation to subjective experience. My second claim is that the approach could open the door to a natural account of the structure of human experience as it is mobilized in itself in such methodology. In this view, generative passages define the type of circulation which explicitly roots the active and disciplined insight the subject has about his/her experience in a biological emergent process.     

Beyond left and right: Automaticity and flexibility of number-space associations

Close links exist between the processing of numbers and the processing of space: relatively small numbers are preferentially associated with a left-sided response while relatively large numbers are associated with a right-sided response (the SNARC effect). Previous work demonstrated that the SNARC effect is triggered in an automatic manner and is highly flexible. Besides the left-right dimension, numbers associate with other spatial response mappings such as close/far responses, where small numbers are associated with a close response and large numbers with a far response. In two experiments we investigate the nature of this association. Associations between magnitude and close/far responses were observed using a magnitude-irrelevant task (Experiment 1: automaticity) and using a variable referent task (Experiment 2: flexibility). While drawing a strong parallel between both response mappings, the present results are also informative with regard to the question about what type of processing mechanism underlies both the SNARC effect and the association between numerical magnitude and close/far response locations.     

THE SYMBOLIC BODY AND THE SYMBOLIC SYMPTOM

The differential analysis of the symbolic expression and of the symbolic symptom enlightens the relation between body, language and symbol. The displacement and condensation, which explain the symptom, involve a bodily perception of a symbolic nature. Consequently, Freud tends to interpret the symbol according to the symptom formation, as opposed to J. Lacan, who equates displacement with metonymy, and condensation with metaphor. The author, in analyzing the similarities and differences, interprets the symptom as a desymbolization, which presupposes a presymbolic perception, which phenomenology has thematized. However, it is language which structures this perception as symbolic, and which introduces the symbolic finality; which the psychological dynamisms do not have by their own selves.     

A validity and reliability study of assessment and screening for sustained withdrawal reaction in infancy: The Alarm Distress Baby scale

Sustained withdrawal behavior in infancy is an important alarm signal to draw attention to both organic and relationship disorders. A withdrawal scale, the Alarm Distress Baby scale (ADBB), for infants between 2 and 24 months of age was built. This article describes the construction of the scale and the assessment of its psychometric properties. The ADBB has good content validity, based on the advice of seven experts. The scale has good criterion validity: first, as a measure of the infant's withdrawal reaction, with a very good correlation between nurse and pediatrician on the ADBB (r_s = 0.84), and second, as a screening procedure for detecting the developmental risk of the infant. The cutoff score of 5 with a sensitivity of 0.82 and a specificity of 0.78 was determined to be optimal for screening purposes. The scale has good construct validity, with good convergent validity with both the Spitz (1951) and the Herzog & Rathbun (1982) lists of symptoms of infant depression (r_s = 0.61 and 0.60, respectively). Exploratory factor analysis showed two different factors, consistent with the scale's construct. Reliability was satisfactory with good internal consistency for both subscales (the Cronbach α = 0.80 for the first subscale and 0.79 for the second) and for the global scale (α = 0.83). The test‐retest procedure showed good stability over time (r_s = 0.90 and 0.84 for the two different raters). The scale could be used in different clinical settings, provided a sufficient level of social stimulation is given to the infant in a relatively brief period of time. The scale can be used by nurses and psychologists or by medical doctors after a short period of training. © 2001 Michigan Association for Infant Mental Health.     

Selective Exposure in the Internet Age: The Interaction between Anxiety and Information Utility

The rise of the Internet forces scholars to reevaluate the frequency and nature of political information seeking in the contemporary period. The functionality of the Internet makes passive exposure more difficult, and selective information seeking easier, than in the past. However, people may also use the Internet in a new and directed way—to arm themselves with information to express and defend their views either online or in the real world. The central question we explore in this paper is what explains balanced versus biased information seeking in the era of the Internet? We combine insights from Sears and Freedman (1967 ) with newer work on emotion to predict motivated selectivity: focusing specifically on the interaction between anxiety and information utility. Our central theoretical claim is that anxiety does not simply boost any information seeking; it triggers information seeking that is useful for addressing the problem at hand. Anxiety alone, therefore, does not guarantee a balanced information search. When counterattitudinal information is useful for some reason—for example, to defend their own opinions to others who may disagree—anxious citizens should seek it out. As a consequence, these subjects should learn more specific information about where each candidate stands on the issues. In an experiment we find support for these hypotheses. We conclude that while today's flexible Internet environment may permit selectivity, balanced seeking should still occur under a fairly common set of circumstances.     

Brain oscillations during semantic evaluation of speech

Changes in oscillatory brain activity have been related to perceptual and cognitive processes such as selective attention and memory matching. Here we examined brain oscillations, measured with electroencephalography (EEG), during a semantic speech processing task that required both lexically mediated memory matching and selective attention. Participants listened to nouns spoken in male and female voices, and detected an animate target (p = 20%) in a train of inanimate standards or vice versa. For a control task, subjects listened to the same words and detected a target male voice in standards of a female voice or vice versa. The standard trials of the semantic task showed enhanced upper beta (25–30 Hz) and gamma band (GBA, 30–60 Hz) activity compared to the voice task. Upper beta and GBA enhancement was accompanied by a suppression of alpha (8–12 Hz) and lower to mid beta (13–20 Hz) activity mainly localized to posterior electrodes. Enhancement of phase-locked theta activity peaking near 275 ms also occurred over the midline electrodes. Theta, upper beta, and gamma band enhancement may reflect lexically mediated template matching in auditory memory, whereas the alpha and beta suppression likely indicate increased attentional processes and memory demands.