Self-reported changes in subjective health and anthrax vaccination as reported by over 900 Persian Gulf War era veterans

A 1999 study of United Kingdom servicemembers by Unwin, et al. recently found significant relationships between anthrax and other vaccinations, reactions to those vaccines, and later health problems for male current or former active military Gulf War veterans. Likewise, in 2000 Steele and in 1998 Gilroy found possible adverse effects of vaccinations on Gulf War veterans. However, the role of such vaccinations remains controversial; more recent government reports continue to dispute the existence of any data that might reflect adversely on the role of vaccinations on the health of Gulf War veterans. To address this controversy, the current study assessed similar relationships for over 900 Reserve Component Gulf War Era veterans from Ohio and nearby states. Gulf War veterans were more likely to report poorer health than non-Gulf veterans. Female veterans were more likely to report mild or severe reactions to vaccines than male veterans. Those veterans who received anthrax vaccine reported more reactions to vaccines than those who did not receive anthrax vaccine. Declines in long-term subjective health were associated with receipt of anthrax vaccine by Gulf War veterans but not for those who did not deploy to the Gulf, although few of the latter received anthrax vaccine. Regardless of deployment status, veterans who reported more severe reactions to vaccines were more likely to report declines in subjective health. Female veterans reported poorer health during the Gulf War than did male veterans, but sex was not related to veterans' reports of subjective health at subsequent times. It is recommended that servicemembers who experience severe reactions to anthrax vaccine be medically reevaluated before receiving further anthrax vaccine and that careful follow-ups be conducted of those receiving the vaccine currently, in accordance with Nass's 1999 recommendations. We also recommend that safer alternatives to thimerosal (a mercury sodium salt, 50% mercury) be used to preserve all vaccines.     

On doing two things at once: IV. Necessary and sufficient conditions: Rejoinder to Lien, Proctor, and Ruthruff (2003)

Four publications have demonstrated perfect timesharing of 1 simultaneous decisions. In all of these, (a). subjects were motivated to respond as quickly as possible, and with 1 exception that involved unusually extensive practice (E. Hazeltine, D. Teague, & R. B. Ivry, 2002, Experiment 4), (b). at least 1 of the 2 tasks was characterized by ideomotor (IM) compatibility, meaning that each task stimulus incorporated a component of the sensory feedback from its required response. Conclusions justified by these reports are that (a). the use of speed-stress instructions is necessary for perfect timesharing of 2 simultaneous decision tasks: (b). when both tasks are IM compatible, perfect timesharing requires little or no practice: (c). extensive practice is needed to achieve perfect timesharing when only 1 of the 2 tasks is IM compatible: and (d). very large amounts of practice can yield perfect timesharing of 2 decision tasks when neither is IM compatible.     

A high-field functional MRI study of quadri-lingual subjects

We assessed six multilingual subjects by functional MRI using a Noun Verb Generation task in four different languages. We hypothesised that the degree of proficiency in each language would be related to the extent of functional activity measured in a region of interest analysis. Proficiency in each language was quantified using two neuropsychological tests. All four languages activated overlapping brain areas, corresponding to the major language regions. The number of activated voxels correlated with proficiency, so that the activated volume increased for languages in which a subject had poorer proficiency. Activation did not appear to be dependent on the age at which the language was learnt.     

The role of atypical antipsychotics in glucose/insulin dysregulation and the evolving role of the psychiatrist in a new era of drug treatment options

This article examines the issue of atypical antipsychotics, glucose/insulin, and other metabolic derangements (ie, metabolic syndrome), including a general introduction to the health concerns of our patients, a review of the literature, possible mechanisms of antipsychotic induced glucose dysregulation, monitoring approaches, and management and prevention of metabolic syndrome. Literature review leads to mechanism hypotheses and risk estimations, leading to guidelines for monitoring and treatment. The patient population suffers from a higher degree of baseline metabolic dysregulation resulting in cardiovascular disease through components of the metabolic syndrome, and this risk increases with administration of atypical antipsychotic medication at different rates, depending on both drug and patient risk factors. The growing knowledge of mechanisms behind drug induced glucose/insulin and other metabolic dysregulation, as well as advances in pharmacogenomics, will help refine drug selection and monitoring for adverse, life-threatening metabolic effects.     

Self-esteem in body dysmorphic disorder

Although studies indicate that poor body image is associated with poor self-esteem, few investigations have examined self-esteem in a clinical sample of individuals with body dysmorphic disorder (BDD). The present study examined self-esteem in 93 BDD patients and change in self-esteem with pharmacotherapy. Subjects completed the Rosenberg Self-Esteem Scale (RSES) and were assessed with other measures. Participants in a placebo-controlled fluoxetine trial completed measures at baseline and endpoint. The mean RSES score was approximately 1.5 SD units lower than means reported for nonclinical samples. Although poorer self-esteem was associated with more severe BDD and depression, as well as greater delusionality, the relationship between self-esteem and BDD severity was largely mediated by depressive symptoms. Self-esteem did not improve significantly more with fluoxetine than placebo, although it improved significantly more in fluoxetine responders than in nonresponders. It is unclear whether poor self-esteem predisposes to BDD and/or is a consequence of the disorder.     

Physical health correlates of overprediction of physical discomfort during exercise

This study sought to determine if overprediction of physical discomfort prior to and following exercise was related to a number of self-report and objective measures of physical health status in a general population sample. Cross-sectional findings indicated a significant and specific relation between patterns of discomfort overprediction (vs under- or accurate prediction) and negative self-reported health status and attitudes to exercise, lower levels of physical activity, as well as poorer scores for resting heart rate, cardiorespiratory fitness and body mass index (but not waist:hip ratio). Females were more likely to overpredict discomfort, were less active and had poorer physical health than males. The potential usefulness of the prediction match-mismatch paradigm for studying exercise-related appraisal processes as proximal determinants of physical activity are discussed. Information obtained from such studies could prove useful in public health education campaigns aimed at increasing levels of physical activity in the general population, particularly among the less active.     

A unified theory of implicit attitudes, stereotypes, self-esteem, and self-concept

This theoretical integration of social psychology's main cognitive and affective constructs was shaped by 3 influences: (a) recent widespread interest in automatic and implicit cognition, (b) development of the Implicit Association Test (IAT; A. G. Greenwald, D. E. McGhee, & J. L. K. Schwartz. 1998), and (c) social psychology's consistency theories of the 1950s, especially F. Heider's (1958) balance theory. The balanced identity design is introduced as a method to test correlational predictions of the theory. Data obtained with this method revealed that predicted consistency patterns were strongly apparent in the data for implicit (IAT) measures but not in those for parallel explicit (self-report) measures. Two additional not-yet-tested predictions of the theory are described.     

Subliminal words activate semantic categories (not automated motor responses)

Semantic priming by visually masked, unidentifiable (“subliminal”) words occurs robustly when the words appearing as masked primes have been classified earlier in practice as visible targets. It has been argued (Damian, 2001) that practice enables robust subliminal priming by automatizing learned associations between words and the specific motor responses used to classify them. Two experiments demonstrate that, instead, the associations formed in practice that underlie subliminal priming are between words and semantic categories. Visible words classified aspleasant or unpleasant in practice with one set of response key assignments functioned later as subliminal primes with appropriate valence, even when associations of keys with valences were reversed before the test. This result shows that subliminal priming involves unconscious categorization of the prime, rather than just the automatic activation of a practiced stimulus-response mapping.     

Using the implicit association test to measure age differences in implicit social cognitions

Two studies investigated the use of the Implicit Association Test (IAT; A. G. Greenwald, D. E. McGhee, & J. L. K. Schwartz, 1998) to study age differences in implicit social cognitions. Study I collected IAT (implicit) and explicit (self-report) measures of age attitudes, age identity, and self-esteem from young, young-old, and old-old participants. Study 2 collected IAT and explicit measures of attitudes toward flowers versus insects from young and old participants. Results show that the IAT provided theoretically meaningful insights into age differences in social cognitions that the explicit measures did not, supporting the value of the IAT in aging research. Results also illustrate that age-related slowing must be considered in analysis and interpretation of IAT measures.