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151.
Mallory R. Sdano Rena J. Vanzo Megan M. Martin Erin E. Baldwin Sarah T. South Alan F. Rope William P. Allen Hutton Kearney 《Journal of genetic counseling》2014,23(6):922-927
Mosaic chromosomal abnormalities are relatively common. However, mosaicism may be missed due to multiple factors including failure to recognize clinical indications and order appropriate testing, technical limitations of diagnostic assays, or sampling tissue (s) in which mosaicism is either not present, or present at very low levels. Blood leukocytes have long been the “gold standard” sample for cytogenetic analysis; however, the culturing process for routine chromosome analysis can complicate detection of mosaicism since the normal cell line may have a growth advantage in culture, or may not be present in the cells that produce metaphases (the lymphocytes). Buccal cells are becoming increasingly utilized for clinical analyses and are proving to have many advantages. Buccal swabs allow for simple and noninvasive DNA collection. When coupled with a chromosomal microarray that contains single nucleotide polymorphic probes, analysis of buccal cells can maximize a clinician’s opportunity to detect cytogenetic mosaicism. We present three cases of improved diagnosis of mosaic aberrations using buccal specimens for chromosomal microarray analysis. In each case, the aberration was either undetectable in blood or present at such a low level it likely could have gone undetected. These cases highlight the limitations of certain laboratory methodologies for identifying mosaicism. We also present practice implications for genetic counselors, including clinic workflow changes and counseling approaches based on increasing use of buccal samples. 相似文献
152.
Aubrey L. Carpenter Anthony C. Puliafico Steven M. S. Kurtz Donna B. Pincus Jonathan S. Comer 《Clinical child and family psychology review》2014,17(4):340-356
Although efficacious psychological treatments for internalizing disorders are now well established for school-aged children, until recently there have regrettably been limited empirical efforts to clarify indicated psychological intervention methods for the treatment of mood and anxiety disorders presenting in early childhood. Young children lack many of the developmental capacities required to effectively participate in established treatments for mood and anxiety problems presenting in older children, making simple downward extensions of these treatments for the management of preschool internalizing problems misguided. In recent years, a number of research groups have successfully adapted and modified parent–child interaction therapy (PCIT), originally developed to treat externalizing problems in young children, to treat various early internalizing problems with a set of neighboring protocols. As in traditional PCIT, these extensions target child symptoms by directly reshaping parent–child interaction patterns associated with the maintenance of symptoms. The present review outlines this emerging set of novel PCIT adaptations and modifications for mood and anxiety problems in young children and reviews preliminary evidence supporting their use. Specifically, we cover (a) PCIT for early separation anxiety disorder; (b) the PCIT-CALM (Coaching Approach behavior and Leading by Modeling) Program for the full range of early anxiety disorders; (c) the group Turtle Program for behavioral inhibition; and (d) the PCIT-ED (Emotional Development) Program for preschool depression. In addition, emerging PCIT-related protocols in need of empirical attention—such as the PCIT-SM (selective mutism) Program for young children with SM—are also considered. Implications of these protocols are discussed with regard to their unique potential to address the clinical needs of young children with internalizing problems. Obstacles to broad dissemination are addressed, and we consider potential solutions, including modular treatment formats and innovative applications of technology. 相似文献
153.
We have argued that it is rational to have asymmetric attitudes toward prenatal and posthumous non-existence insofar as this asymmetry is a special case of a more general (and arguably rational) asymmetry in our attitudes toward past and future pleasures. Here we respond to an interesting critique of our view by Jens Johansson. We contend that his critique involves a crucial and illicit switch in temporal perspectives in the process of considering modal claims (sending us to other possible worlds). 相似文献
154.
Heather Harris Wright Anthony D. Koutsoftas Gilson J. Capilouto Gerasimos Fergadiotis 《Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition》2014,21(2):174-196
The purpose of the present research was to examine the influence of cognitive processes on discourse global coherence ability measured across different discourse tasks and collected from younger (n = 40; 20–39 years) and older (n = 40; 70–87 years) cognitively healthy adults. Study participants produced oral language samples in response to five commonly used discourse elicitation tasks and they were analyzed for maintenance of global coherence. Participants also completed memory and attention measures. Group differences on the global coherence scale were found for only one type of discourse—recounts. Across discourse elicitation tasks the lowest global coherence scores were found for recounts compared to the other discourse elicitation tasks. The influence of cognitive processes on maintenance of global coherence differed for the two age groups. For the younger group, there were no observed significant relationships. For the older group, cognitive measures were related to global coherence of stories and procedures. 相似文献
155.
Michael Anthony Abril 《International Journal of Systematic Theology》2014,16(3):251-272
As a case study in Thomas Aquinas' use of Scripture, this article examines his appeals to Lamentations 5:21 over the course of his career, highlighting the ways in which it informs the development of his mature theology of the grace of conversion. These considerations show how key Scripture verses not only inspire the material content of Thomas' theology, but also serve as indispensible formal components for its expression. 相似文献
156.
157.
Morris Stephanie S. J. Musser Erica D. Tenenbaum Rachel B. Ward Anthony R. Raiker Joseph S. Coles Erika K. 《Journal of abnormal child psychology》2022,50(5):591-603
Research on Child and Adolescent Psychopathology - Psychostimulants are commonly prescribed medications for youth with attention-deficit/hyperactivity disorder (ADHD). Limited studies have... 相似文献
158.
Employment‐based abstinence reinforcement promotes opiate and cocaine abstinence in out‐of‐treatment injection drug users 下载免费PDF全文
159.
Anthony Robert Booth 《Synthese》2014,191(8):1867-1880
According to the doxastic compatibilist, compatibilist criteria with respect to the freedom of action rule-in our having free beliefs. In Booth (Philosophical Papers 38:1–12, 2009), I challenged the doxastic compatibilist to either come up with an account of how doxastic attitudes can be intentional in the face of it very much seeming to many of us that they cannot. Or else, in rejecting that doxastic attitudes need to be voluntary in order to be free, to come up with a principled account of how her criteria of doxastic freedom are criteria of freedom. In two recent papers, Steup (Synthese 188:145–163, 2012; Dialectica 65(4):559–576, 2011) takes up the first disjunct of the challenge by proposing that even though beliefs cannot be practically intentional, they can be epistemically intentional. McHugh (McHugh forthcoming) instead takes up the second disjunct by proposing that the freedom of belief be modelled not on the freedom of action but on the freedom of intention. I argue that both Steup’s and McHugh’s strategies are problematic. 相似文献
160.
Todd S. Braver Marie K. Krug Kimberly S. Chiew Wouter Kool J. Andrew Westbrook Nathan J. Clement R. Alison Adcock Deanna M. Barch Matthew M. Botvinick Charles S. Carver Roshan Cools Ruud Custers Anthony Dickinson Carol S. Dweck Ayelet Fishbach Peter M. Gollwitzer Thomas M. Hess Derek M. Isaacowitz Mara Mather Kou Murayama Luiz Pessoa Gregory R. Samanez-Larkin Leah H. Somerville 《Cognitive, affective & behavioral neuroscience》2014,14(2):443-472
Recent years have seen a rejuvenation of interest in studies of motivation–cognition interactions arising from many different areas of psychology and neuroscience. The present issue of Cognitive, Affective, & Behavioral Neuroscience provides a sampling of some of the latest research from a number of these different areas. In this introductory article, we provide an overview of the current state of the field, in terms of key research developments and candidate neural mechanisms receiving focused investigation as potential sources of motivation–cognition interaction. However, our primary goal is conceptual: to highlight the distinct perspectives taken by different research areas, in terms of how motivation is defined, the relevant dimensions and dissociations that are emphasized, and the theoretical questions being targeted. Together, these distinctions present both challenges and opportunities for efforts aiming toward a more unified and cross-disciplinary approach. We identify a set of pressing research questions calling for this sort of cross-disciplinary approach, with the explicit goal of encouraging integrative and collaborative investigations directed toward them. 相似文献