全文获取类型
收费全文 | 22804篇 |
免费 | 98篇 |
出版年
2023年 | 18篇 |
2022年 | 18篇 |
2021年 | 35篇 |
2020年 | 49篇 |
2019年 | 48篇 |
2018年 | 3528篇 |
2017年 | 2863篇 |
2016年 | 2314篇 |
2015年 | 251篇 |
2014年 | 133篇 |
2013年 | 341篇 |
2012年 | 689篇 |
2011年 | 2486篇 |
2010年 | 2587篇 |
2009年 | 1551篇 |
2008年 | 1777篇 |
2007年 | 2271篇 |
2006年 | 115篇 |
2005年 | 297篇 |
2004年 | 254篇 |
2003年 | 192篇 |
2002年 | 141篇 |
2001年 | 70篇 |
2000年 | 83篇 |
1999年 | 50篇 |
1998年 | 60篇 |
1997年 | 53篇 |
1996年 | 39篇 |
1995年 | 35篇 |
1994年 | 31篇 |
1993年 | 25篇 |
1992年 | 28篇 |
1991年 | 31篇 |
1990年 | 27篇 |
1989年 | 20篇 |
1988年 | 28篇 |
1987年 | 20篇 |
1986年 | 22篇 |
1985年 | 27篇 |
1984年 | 22篇 |
1983年 | 25篇 |
1982年 | 28篇 |
1981年 | 20篇 |
1980年 | 22篇 |
1979年 | 22篇 |
1978年 | 16篇 |
1977年 | 16篇 |
1976年 | 19篇 |
1975年 | 14篇 |
1973年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
951.
Courtney Lynam Scherr Jessica L. Feuston Dawn M. Nixon Stephanie A. Cohen 《Journal of genetic counseling》2018,27(2):439-445
Professional organizations provide surveillance guidelines for BRCA1 and BRCA2 (BRCA) carriers with intact breasts and/or ovaries to facilitate early cancer detection. However, literature indicates adherence to surveillance guidelines is inconsistent at best. Using the Messaging Model for Health Communication Campaigns framework, we undertook a two-phase formative research approach to develop an intervention to promote adherence to surveillance guidelines. Discussion groups identified preferred intervention format and function in phase I. Findings indicated carriers desired a phone application (app) to assist with surveillance management and appointment tracking. Thus, an iPhone app for carriers to track appointments based on published surveillance guidelines was developed. In phase II, we obtained feedback from BRCA carriers via a survey during a prototype demonstration at a regional conference. Participants in phase II wanted reminder capabilities and the ability to add and modify information fields. This feedback informed intervention modifications, resulting in the Scheduling Necessary Advised Procedures (SNAP) iPhone app currently being pilot tested by BRCA carriers throughout the USA. 相似文献
952.
Krister W. Fjermestad Livø Nyhus Øivind J. Kanavin Arvid Heiberg Lise B. Hoxmark 《Journal of genetic counseling》2018,27(5):1102-1110
Neurofibromatosis type 1 (NF1) is a genetic, autosomal dominant multi-organ disease characterized by susceptibility to tumor formation, changes in skin pigmentation, skeletal abnormalities, and neuropsychological deficits. Clinical studies have shown impaired health-related quality of life (HQoL) in adults with NF1. However, little is known about HQoL in non-clinical NF1 samples. We conducted a cross-sectional self-report survey of 142 persons with NF1 (M age?=?50.3 years, SD?=?12.0, range 32 to 80; 62.0% females) recruited from non-clinical settings. Several HQoL domains, including life satisfaction, mental health, sleep, pain, gastrointestinal problems, oral health, and social support, were compared between the NF1 sample and 46,293 controls from the HUNT3 population study. We also examined gender differences within the NF1 sample and predictors of HQoL. Compared to controls, the NF1 sample reported significantly poorer life satisfaction, mental health, sleep, and oral health, and more pain, gastrointestinal problems, comorbid diseases, and memory problems. Several HQoL domains were significantly correlated. Mental health was the only unique significant predictor of overall life satisfaction. Women with NF1 reported significantly more mental health, sleep, and pain problems than men with NF1. Mental health assessment and management should be integrated into clinical care of persons with NF1 to potentially improve their HQoL. 相似文献
953.
954.
Kristin A. Maloney Dina S. Alaeddin Rainer von Coelln Shannan Dixon Lisa M. Shulman Katrina Schrader Yue Guan 《Journal of genetic counseling》2018,27(5):1200-1209
The objective of this study was to assess the genetics knowledge of patients with Parkinson’s disease (PD), and to explore their attitudes on genetic testing and interest in genetic counseling. We surveyed 158 patients from the University of Maryland Parkinson’s Disease and Movement Disorders Center. Patients averaged a score of 63% on general genetics knowledge and 73% on PD genetics knowledge. Participants had an overall positive attitude toward genetic testing: 80% believed that the use of genetic tests among people should be promoted, and 83% would undertake genetic test for PD if it was available. Patients reported a high interest to discuss the benefits, risks, and impacts of genetic testing for PD (mean sum score?=?26, range?=?9–35), and 43% patients expressed interest in meeting with a genetic counselor. Multivariate regression analysis showed that patients who had more positive attitudes toward genetic testing for PD were more interested in meeting with a genetic counselor (β?=?0.6, p?<?0.001). This study is the first to demonstrate an interest in genetic counseling among patients with PD. Our findings demonstrate a new niche for genetic counselors to support patients in clarifying gaps or misconceptions in knowledge about PD genetics as well as the possible risks, benefits, and limitations of genetic testing. 相似文献
955.
Devanshi Patel Erica L. Blouch Linda H. Rodgers-Fouché Margaret M. Emmet Kristen M. Shannon 《Journal of genetic counseling》2018,27(6):1318-1327
The current practice of cancer genetic counseling is undergoing widespread change and scrutiny. While there are clinical resources for genetic counselors (GCs) regarding the delivery of cancer genetic services, there is limited literature regarding effective management of a genetic counseling clinical program. We have developed administrative tools to manage a large team of GCs at a single academic medical center over a period of increasing demand for genetics services, with the initial aim of decreasing wait time for urgent genetic counseling visits. Here, we describe the three main elements of the clinical operations: Balancing patient volume between GCs, scheduling tracks for both routine and urgent appointments, and a team of triaging GCs to ensure appropriate patient referrals. For each of these elements, we describe how they have been modified over time and present data to support the utility of these strategies. The preliminary evidence offered here suggests that these tools allow for an equitable distribution of patient volume between team members, as well as the timely and accurate scheduling of urgent patients. As a result of the experiences presented here, other genetic counseling programs grappling with similar issues should be aware that it is possible to shift clinical operations to serve certain patient populations in a more timely fashion while keeping both providers and GC staff satisfied. 相似文献
956.
Wendy Hadley Amy Lansing David H. Barker Larry K. Brown Heather Hunter Geri Donenberg Ralph J. DiClemente 《Journal of child and family studies》2018,27(4):1098-1109
Parents can play a vital role in shaping teenagers’ sexual attitudes, behavior, and contraceptive use through communication, however, less is known about how to modify parent–adolescent communication among youth with mental health problems. The impact of a family-based sexual risk prevention intervention on both observational and self-report of parent–adolescent sexual communication was examined at 12 months among adolescents with mental health problems. Of the 721 parent–adolescent dyads recruited for the study, 167 videotapes of sexual discussions between parents and adolescent were coded for the family-based intervention and 191 videotapes for the active comparison. Longitudinal analyses examined differences between conditions (family-based vs. comparison) in self-reported and observed parent–adolescent sexual discussions and also examined the impact of gender on intervention response. More parent I-statements, healthier parent body language, and fewer adolescent Negative Vocalizations were detected for family-based intervention participants 12 months after participating in the brief intervention (11?h of total intervention time) relative to those in the comparison condition. Parents in the family-based intervention also self-reported better sexual communication at 12 months. The current study provides supporting evidence that a relatively brief family-based intervention was successful at addressing parent–adolescent sexual communication among a mental health sample. 相似文献
957.
Lauren M. Keeley Bridget A. Makol Noor Qasmieh Danielle E. Deros Jeremy N. Karp Melanie F. Lipton Tara M. Augenstein Michelle L. Truong Sarah J. Racz Andres De Los Reyes 《Journal of child and family studies》2018,27(4):1041-1053
Adolescents experiencing social anxiety often experience co-occurring attention-deficit/hyperactivity disorder (ADHD) symptoms. Yet, assessing for social anxiety poses challenges given the already time-consuming task of distinguishing social anxiety from other commonly co-occurring internalizing conditions (e.g., generalized anxiety, major depression). Assessors need short screening devices to identify socially anxious adolescents in need of intensive ADHD assessments. A six-item version of the ADHD Self-Report Scale (ASRS-6) was originally developed to identify adults who likely meet diagnostic criteria for ADHD, but its psychometric properties have yet to be examined among adolescents. We tested the psychometric properties of the ASRS-6 when administered in clinical assessments for adolescent social anxiety. Eighty-nine 14–15 year old adolescents and their parents (67.4% female; 62.1% African American; 30 Clinic-Referred; 59 Community Control) completed the ASRS-6, measures of adolescent social anxiety and depressive symptoms, and parent-adolescent conflict. Adolescent self-reported and parent-reported ASRS-6 positively related with scores from established measures of social anxiety, depressive symptoms, and parent-adolescent conflict. Further, adolescent self-reported (but not parent-reported) ASRS-6 scores significantly discriminated adolescents on referral status. Adolescent self-reported (but not parent-reported) ASRS-6 scores incrementally predicted social anxiety over-and-above depressive symptoms, which commonly co-occur with social anxiety. Conversely, parent-reported (but not adolescent self-reported) ASRS-6 scores incrementally predicted parent-adolescent conflict over-and-above depressive symptoms, which commonly co-occur with conflict. When assessing adolescent ADHD symptoms, adolescents’ and parents’ reports meaningfully vary in their links to validity indicators. As such, among adolescents assessed for social anxiety, clinical assessments of adolescent ADHD symptoms should include both parent reports and adolescent self-reports. 相似文献
958.
Tamar Silberg Hila Drucker-Bezalel Maya Gerner Tal Krasovsky Ety Berant Amichai Brezner Jana Landa 《Journal of child and family studies》2018,27(5):1473-1481
Functional somatic symptoms (FSS), defined as physical symptoms of unknown pathology, are common among children and adolescents and are often associated with high levels of functional impairment. Self-discrepancy theory (SDT) suggests that discrepancies between one’s ideal, ought, or undesired self-states and one’s actual self-representation may lead to emotional distress. Among families with dysfunctional patterns, such emotional distress may result in FSS. The current study examined the relationship between familial patterns and children’s levels of self-discrepancies, among children with and without FSS. Twenty-three children diagnosed with FSS and 23 children with orthopedic problems (non-FSS) and their mothers participated in the study. Mothers and children completed the Child Somatization Inventory and the Integrated Self-Discrepancies Index. Mothers also completed the general scale of the Family Assessment Device. Higher levels of symptom intensity were found in the FSS group than in the non-FSS group. Dysfunctional familial patterns were significantly higher in the FSS group, and higher levels of discrepancies were reported in the FSS group, compared with the non-FSS group. No significant relationship was found in the FSS group between level of self-state discrepancies and level of family functioning. Higher levels of dysfunctional patterns are observed among families of children with FSS. Furthermore, children with FSS and their mothers hold relatively high levels of self-state discrepancies. However, these elevated discrepancies are not significantly related to familial dysfunctional patterns. Viewing self-state discrepancies together with family maladaptive patterns might help address both inter- and intrapersonal conflicts within the family and reduce children’s symptoms. 相似文献
959.
Mikaela J. Dufur John P. Hoffmann Lance D. Erickson 《Journal of child and family studies》2018,27(3):802-815
Research suggests that children of single parents are at heightened risk of precocious sexual behavior, STDs, and other risky sexual outcomes. However, few such studies have addressed the type of single-parent family (single mother or single father), or differences across other-sex parent–child dyads. While gender essentialist models assume differences among youth living only with mothers or with fathers, constructivist models propose more flexible modes of parenting that lead to more similar outcomes. Using data from the National Longitudinal Study of Adolescent to Adult Health (n?=?2570) on youth between the ages of 15 and 19, we compared sexually-related outcomes among adolescents, both boys and girls, who lived with a single mother or a single father. These outcomes include sexual intercourse and knowledge, use of contraception, attitudes toward intimacy and pregnancy, and diagnosis of sexually-transmitted diseases. The results from linear and logistic regression models indicated few differences between single-mother and single-father families, or between same-sex and opposite-sex parent–child matches, using p values of .05 or smaller. Our results called into question essentialist models that posit higher risks for adolescents living with a particular parent or with an opposite-sex parent. 相似文献
960.
The study aimed to examine the psychometric properties of the Chinese revision of the Emotional and Behavioral Screener (EBS), and to extend its application to preschoolers (4–7 years old). Teachers and parents of 216 preschoolers (age M?=?5.11, SD?=?0.9) were invited to complete the EBS, and some of the teachers were also asked to complete the Preschool Behavioral and Emotional Rating Scale (PreBERS) (N?=?80) and the Strength and Difficulties Questionnaires (SDQ) (N?=?90). Results of confirmatory factor analysis suggested that the original single-factor model of the EBS didn’t fit the data well. Based on the results of a series of exploratory factor analyses, we proposed a two-factor model instead, representing externalizing and internalizing problems respectively. The Chinese revision demonstrated satisfactory internal reliability, inter-rater reliability, convergent validity and divergent validity. All these evidences supported its use among Chinese preschoolers to identify those who will be at risk of suffering from emotional and behavioral disturbances. 相似文献