Deviations in the emergence of representations: a neuroconstructivist framework for analysing developmental disorders

A common way of studying developmental disorders is to adopt a static neuropsychological deficit approach, in which the brain is characterized in terms of a normal brain with some parts or ‘modules’ impaired. In this paper we outline a neuroconstructivist approach in which developmental disorders are viewed as alternative developmental trajectories in the emergence of representations within neural networks. As a concrete instantiation of the assumptions underlying this general approach, we present a number of simulations in an artificial neural network model. The representations that emerge under different architectural, input and developmental timing conditions are then analysed within a multi‐dimensional state space. We explore alternative developmental trajectories in these simulations, demonstrating how initial differences in the same parameter can lead to very different outcomes, and conversely how different starting states can sometimes result in similar end states (phenotypes). We conclude that the assumptions of the neuroconstructivist approach are likely to be more appropriate for analysing developmental deviations in complex dynamic neural networks, such as the human brain.     

Specialization of the motor system in infancy: from broad tuning to selectively specialized purposeful actions

In executing purposeful actions, adults select sufficient and necessary limbs. But infants often move goal‐irrelevant limbs, suggesting a developmental process of motor specialization. Two experiments with 9‐ and 12‐month‐olds revealed gradual decreases in extraneous movements in non‐acting limbs during unimanual actions. In Experiment 1, 9‐month‐olds produced more extraneous movements in the non‐acting hand/arm and feet/legs than 12‐month‐olds. In Experiment 2, analysis of the spatiotemporal dynamics of infants’ movements revealed developmental declines in the spatiotemporal coupling of movements between acting and non‐acting arms. We also showed that the degree of specialization in infants’ unimanual actions is associated with individual differences in motor experience and visual attention, indicating the experience‐dependent and broad functional nature of these developmental changes. Our study provides important new insights into motor development: as in cognitive domains, motor behaviours are initially broadly tuned to their goal, becoming progressively specialized during the first year of life.     

The Experience in Personal Social Systems Questionnaire (EXIS.pers): Development and Psychometric Properties

This study presents the theoretical background, development, and psychometric properties of the German and English versions of the Experience in Personal Social Systems Questionnaire (EXIS.pers). It assesses how the members of a personal social system experience their situation within that system. It is designed as a research tool for interventions in which only one member of the system participates (e.g., Family Constellation Seminars). The EXIS.pers was created to measure change on the individual level relating to one's own important personal social system. In Study 1, we used exploratory factor analysis (EFA) for latent variable identification of the original German EXIS.pers (n = 179). In Studies 2 and 3, we used confirmatory factor analysis (CFA) to examine the dimensionality of the German (n = 634) and English (n = 310) EXIS.pers. Internal consistencies and cross‐cultural structural equivalence were assessed. EFA indicated that a four‐factor model provided best fit for the German EXIS.pers. For both the German and English EXIS.pers, CFA provided the best fit for a five‐factor bi‐level model that included a general factor (Experience In Personal Social Systems) and four dimensions (Belonging, Autonomy, Accord, Confidence). Good internal consistencies, external associations, and cross‐cultural structural equivalence were demonstrated. This study provides first evidence for the German and English EXIS.pers as an economical and reliable measure of an individual's experience within his or her personal social systems.     

Gender Specificity of Children’s Narrative Representations in Predicting Depressive Symptoms at Early School Age

Our longitudinal study contributes to the body of literature on depression in childhood by examining potential protective factors. We investigated the influence of maternal depressive symptoms on child depressive symptoms at early school age and its gender-specific moderation by children’s narrative representations of the maternal figure, over and above children’s own depressive symptoms at preschool age. Children’s narrative representations were assessed using the MacArthur Story Stem Battery in 170 preschool children (92 girls; 54.1?%) oversampled for internalizing symptoms. Children’s depressive symptoms were assessed at preschool age (Time 1; 4–6 years) and at early school age (Time 2; 6–8 years) by maternal report; mothers’ depressive symptoms were assessed at Time 1. The results showed that for boys, only their own depressive symptoms at Time 1 predicted their depressive symptoms at Time 2. For girls, maternal depressive symptoms were a significant risk factor for their own depressive symptoms at Time 2. Regarding this association, we also found a moderation effect: girls with more positive narrative representations of the maternal figure showed a reduced negative impact of maternal depressive symptoms on their own depressive symptoms at Time 2. This implies that clinical practice should screen a child for early depressive symptoms, especially if the mother displays depressive symptoms. Clinicians might also assess children’s inner working models, which can serve as a protective factor.     

Interdisziplin?re Systemintegration und Innovationsgenese: Ein methodologischer Zugang f��r die interdisziplin?re Forschung

The increasing significance of inter- and transdisciplinary research raises the demand for principles with respect to methodology and philosophy of science. The discussion of this question leads to the development of an interdisciplinary research process with two methodic core areas: system integration and inducement of innovation. It will be shown that interdisciplinary research can be understood as a discipline of its own, while its potential of synthesis cannot be declared as a central distinctive feature relative to other disciplines. In fact the developed methodology is firstly aligned analytically, with a focus on the research potential from the area of tension between individual disciplines. This results in an interdisciplinary methodology, generating epistemological progress, which can be applied to complex and cooperation intensive research in academia as well as industry and society.     

Tuberculosis detection by giant african pouched rats

In recent years, operant discrimination training procedures have been used to teach giant African pouched rats to detect tuberculosis (TB) in human sputum samples. This article summarizes how the rats are trained and used operationally, as well as their performance in studies published to date. Available data suggest that pouched rats, which can evaluate many samples quickly, are sufficiently accurate in detecting TB to merit further investigation as a diagnostic tool.     

Cognitive fatigue defined in the context of attention networks

We examined the effect of cognitive fatigue on the Attention Networks Test (ANT). Participants were 228 non-demented older adults. Cognitive fatigue was operationally defined as decline in alerting, orienting, and executive attention performance over the course of the ANT. Anchored in a theoretical model implicating the frontal basal ganglia circuitry as the core substrate of fatigue, we hypothesized that cognitive fatigue would be observed only in executive attention. Consistent with our prediction, significant cognitive fatigue effect was observed in executive attention but not in alerting or orienting. In contrast, orienting improved over the course of the ANT and alerting showed a trend, though insignificant, that was consistent with learning. Cognitive fatigue is conceptualized as an executive failure to maintain and optimize performance over acute but sustained cognitive effort resulting in performance that is lower and more variable than the individual's optimal ability.     

Evaluation of a DVD-based self-help program in highly socially anxious individuals--pilot study

High social anxiety is a risk factor for the incidence of social anxiety disorder (SAD). Early diagnosis and intervention may prevent more severe psychiatric courses. Self-help programs may be a convenient, accessible, and effective intervention. This study examined the efficacy of a newly developed self-help program for SAD in individuals with subthreshold social anxiety. A total of 24 highly socially anxious individuals were randomly assigned to a DVD-based self-help program or to a wait-list control group. The self-help program is based on the cognitive model according to Clark and Wells (1995; adapted to German by Stangier, Clark, & Ehlers, 2006) and comprises eight sessions. ANOVAs based on an intention-to-treat model were used for data analyses. The self-help program was well accepted; just one person withdrew during the intervention. There were significant Time × Group interactions on all primary outcome measures. For the intervention group moderate to high within-groups effect sizes up to Cohen's d = 1.05 were obtained. Between-groups effect sizes ranged from 0.24 to 0.65 in favor of the active intervention. The newly developed DVD-based self-help program seems to be a promising intervention for highly socially anxious individuals as it reduces social anxiety symptoms.     

Letting go of unmet goals: Does self-focused rumination impair goal disengagement?

Self-regulation of behavior frequently requires that people disengage from goals that are too difficult to attain. The current studies investigate whether self-focused rumination hinders the execution of this crucial self-regulatory competence. In study one, participants attempted to solve anagrams, some of which were unsolvable, and their predisposition to engage in self-focused rumination was assessed. The tendency to ruminate was associated with getting stuck in the attempt to solve unsolvable anagrams. In study two, ruminative thoughts were manipulated by asking participants to focus on their self, personality, and goals in life, a task frequently employed to induce rumination. Compared to participants undergoing a distraction induction, ruminating participants were more likely to get stuck trying to solve unsolvable anagrams. These results suggest that self-focused rumination hinders disengagement from unattainable goals.