Increased Error-Related Brain Activity in Six-Year-Old Children with Clinical Anxiety

Anxiety disorders are the most frequently diagnosed form of psychopathology in children and often result in chronic impairment that persists into adulthood. Identifying neurobehavioral correlates of anxiety that appear relatively early in life would inform etiological models of development and allow intervention and prevention strategies to be implemented more effectively. The error-related negativity (ERN), a negative deflection in the event-related potential at fronto-central sites approximately 50 ms following the commission of errors, has been consistently found to be larger among anxious adults. The current study sought to extend these findings to even younger individuals: the ERN was elicited by a Go/NoGo task in 48 six year-old children with a clinical anxiety disorder assessed by diagnostic interview and 48 age-matched controls. In addition to child anxiety disorder, the ERN was examined in relation to maternal history of anxiety disorder, which was previously related to a smaller ERN. Anxious children were characterized by a larger (i.e., more negative) ERN and maternal history of anxiety disorder was associated with a smaller ERN. Thus, the relationship between an increased ERN and clinical anxiety is evident by age 6, and this effect appears independent from an opposing influence of maternal anxiety history on the ERN. These findings support the ERN as a promising neurobehavioral marker of anxiety, and implications are discussed.     

Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients

Introduction

Adaptation to changing situations can be mediated by two strategies: (1) Evaluation of a response and (2) Evaluation of outcome values in relation to objects. Previous studies indicate that response shifting is associated with a network comprising the left frontal cortex and parietal cortex connected by the superior longitudinal fascicle, whereas outcome evaluation is associated with a network consisting of the orbitofrontal cortex, amygdala and uncinate fascicle. However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems.

Methods

We analyzed stimulus response shifting and stimulus outcome shifting in two studies, one fMRI-study on healthy participants and one study on patients with MS involving structural MRI (Diffusion Tensor Imaging, Voxel Based Morphometry, Ventricular volumetry). Two tasks were used, identical in presentation but different in instruction, controlling for effects of lower level processing. In the SRS task, participants had to perform a “Go” or “NoGo” response depending on a stimulus change: if the stimulus remained the same, they had to continue with the former type of response, if it changed they had to adapt their response pattern. In the SOS task they had to perform a “Go” response only if the presented stimulus corresponded to that of an internal alternating series.

Results

fMRI findings showed that SRS is related to a bilateral parietal-premotor network. In the left hemisphere the prefrontal cortex was also involved. SOS was lateralized to the right hemisphere, particularly to the anterior temporal pole and amygdala, and the inferior parietal cortex. MS patients impaired on this task suffered from lesions in the right uncinate fascicle and showed an enlarged right frontal lateral ventricle.

Conclusion

With physically identical tasks, a functional neuronal segregation can be demonstrated for stimulus response shifting (bilateral activations with a focus in the left prefrontal cortex) and stimulus outcome shifting (right anterior temporal lobe and right supramarginal gyrus).     

A Psychometric Evaluation of the Approach and Avoidance of Alcohol Questionnaire Among Alcohol-Dependent Patients Attending Residential Treatment

Despite research suggesting that alcohol-dependent individuals have both craving and avoidant tendencies for alcohol, few studies have measured self-report tendencies using the Approach and Avoidance of Alcohol Questionnaire (AAAQ). The goal of this study was to examine the psychometric properties of the AAAQ using a sample of adults receiving 12 step-based residential treatment for alcohol dependence. As part of a larger study, 100 adults receiving residential treatment completed the AAAQ and several other assessments shortly after treatment admission. Analyses of the AAAQ examined its factor structure, internal consistency, and convergent and predictive validity. A maximum likelihood estimation factor analysis using oblique rotation produced 3 factors accounting for 69 % of the variance. A confirmatory factor analysis suggested that the 3-factor model was a moderate fit for data from a second sample of patients. Internal consistency was fairly high and convergent validity was demonstrated by relationships with another scale of alcohol craving, time since last drink, and quantity and frequency of pre-treatment alcohol use. Regarding predictive validity, the level of approach tendencies on the AAAQ was significantly related to abstinence status during the first 6 months following treatment. Avoidance level was not related to abstinence. The results largely replicated past studies utilizing outpatient samples and suggest that the AAAQ shows promise as a psychometrically sound, internally reliable self-report craving measure for individuals with alcohol dependence.     

How benefits of expressive writing vary as a function of writing instructions,ethnicity and ambivalence over emotional expression

Written emotional disclosure has been reported to confer a variety of benefits on physical and psychological well-being. However, variable findings suggest that outcomes may vary systematically as a function of specific parameters of the experimental design. This study aims to investigate the unique and combined effects of disclosure instructions focusing on emotional expression and instructions facilitating cognitive reappraisal and to examine how ambivalence over emotional expression and ethnicity moderate the effects of these writing instructions. Seventy-one Asian and 59 Caucasian undergraduates (N = 130) with at least minimal physical or depressive symptoms were randomly assigned to one of the four writing conditions: emotional disclosure (ED), cognitive reappraisal (COG), the combination of ED and COG, or a control condition. Self-reported physical symptoms, positive affect (PA) and negative affect were assessed at baseline and three follow-ups spanning 4 months. Mixed linear models revealed that COG writing reduced physical symptoms, ED buffered a decrease in PA over time, and the combination of ED and COG (i.e. self-regulation; SR) was most effective. Asians and highly ambivalent participants benefited most from expressive writing. Findings contribute to the development of a SR moderator model and carry implications for designing expressive disclosure studies, particularly for ethnic minorities.     

Origin of the initial rapid age hardening in an Al-1.7 at.% Mg-1.1 at.% Cu alloy

The origin of the rapid hardening which occurs during the initial ageing stage of an Al-1.7 at.% Mg-1.1 at.% Cu alloy has been investigated by the threedimensional atom-probe (3DAP) and transmission electron microscopy techniques. Although the rapid hardening reaction occurs within 1 min at 150 degrees C, no evidence for solute clusters or Guinier-Preston-Bagaryatsky (GPB) zones was detected using the 3DAP after this ageing time. When a short-term aged specimen is deformed and then aged at 150 degrees C, further rapid hardening occurs. This suggests that the rapid hardening is associated with a solutedislocation interaction. Uniform dispersions of Cu-Mg co-clusters do not occur until closer to the end of the hardness plateau and it is thought that these evolve into GPB zones during the second stage of the age-hardening process.     

Reduced Reliance on Optimal Facial Information for Identity Recognition in Autism Spectrum Disorder

Previous research into face processing in autism spectrum disorder (ASD) has revealed atypical biases toward particular facial information during identity recognition. Specifically, a focus on features (or high spatial frequencies [HSFs]) has been reported for both face and nonface processing in ASD. The current study investigated the development of spatial frequency biases in face recognition in children and adolescents with and without ASD, using nonverbal mental age to assess changes in biases over developmental time. Using this measure, the control group showed a gradual specialization over time toward middle spatial frequencies (MSFs), which are thought to provide the optimal information for face recognition in adults. By contrast, individuals with ASD did not show a bias to one spatial frequency band at any stage of development. These data suggest that the “midband bias” emerges through increasing face-specific experience and that atypical face recognition performance may be related to reduced specialization toward optimal spatial frequencies in ASD.     

Repeated Measurement of the Components of Attention With Young Children Using the Attention Network Test: Stability,Isolability, Robustness,and Reliability

The current study examined the robustness, stability, reliability, and isolability of the attention network scores (alerting, orienting, and executive control) when young children experienced repeated administrations of the child version of the Attention Network Test (ANT; Rueda et al., 2004 Rueda , M. R. , Fan , J. , McCandliss , B. D. , Halparin , J. D. , Gruber , D. B. , Lercari , L. P. , … Posner , M. I. ( 2004 ). Development of attentional networks in childhood . Neuropsychologia , 42 , 1029 – 1040 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Ten test sessions of the ANT were administered to 12 young children. Participants were asked to indicate the direction of a target fish, flanked by distractors, presented either above or below the fixation cross following different types of visual cues. Network scores, reflecting alerting, orienting, and executive control, were calculated using orthogonal subtractions of performance in selected conditions. Only the alerting network scores remained highly significant across the 10 sessions. The executive network scores showed some practice effects. The reliability of the network scores remained poor regardless of the amount of data. Based on the results, use of the ANT is cautioned against in young children when repeated testing is required.     

Constancy and the Changes: A Comparative Reading of Heng Xian

This article explores the connection between the Heng Xian and the Changes of Zhou tradition, especially the “Tuan” and “Attached Verbalizations” commentaries. Two important Heng Xian terms—heng 恆 and fu 復—are also Changes of Zhou hexagrams and possible connections are explored. Second, the Heng Xian account of the creation of names is compared with the “Attached Verbalizations” account of the creation of the Changes of Zhou system. Third, the roles played by knowing and desire in both Heng Xian and the Changes of Zhou tradition are explored, with particular focus on potential points of similarity. Finally, insights gained through these comparisons are used to interpret the Heng Xian advice on initiating action.