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71.
The Organization of Extrinsic Neurons and Their Implications in the Functional Roles of the Mushroom Bodies in Drosophila melanogaster Meigen 总被引:1,自引:0,他引:1 下载免费PDF全文
Kei Ito Kazumi Suzuki Patricia Estes Mani Ramaswami Daisuke Yamamoto Nicholas J. Strausfeld 《Learning & memory (Cold Spring Harbor, N.Y.)》1998,5(1):52-77
Although the importance of the Drosophila mushroom body in olfactory learning and memory has been stressed, virtually nothing is known about the brain regions to which it is connected. Using Golgi and GAL4–UAS techniques, we performed the first systematic attempt to reveal the anatomy of its extrinsic neurons. A novel presynaptic reporter construct, UAS-neuronal synaptobrevin–green fluorescent protein (n-syb–GFP), was used to reveal the direction of information in the GAL4-labeled neurons. Our results showed that the main target of the output neurons from the mushroom body lobes is the anterior part of the inferior medial, superior medial, and superior lateral protocerebrum. The lobes also receive afferents from these neuropils. The lack of major output projections directly to the deutocerebrum’s premotor pathways discourages the view that the role of the mushroom body may be that of an immediate modifier of behavior. Our data, as well as a critical evaluation of the literature, suggest that the mushroom body may not by itself be a “center” for learning and memory, but that it can equally be considered as a preprocessor of olfactory signals en route to “higher” protocerebral regions. 相似文献
72.
W. K. Estes 《Psychometrika》1957,22(2):113-132
The methods used in recent probabilistic learning models to generate mean curves of learning under random reinforcement are extended to the general case in which probability of reinforcement may vary in any specified manner as a function of trials and to cases in which probability of reinforcement on a given trial is contingent upon responses or outcomes of preceding trials.This paper was prepared while the writer was in residence at the Center for Advanced Study in the Behavioral Sciences, Stanford, California. The research on which it is based was supported by a faculty research grant from the Social Science Research Council. 相似文献
73.
Martina Zemp Anne Milek E. Mark Cummings Annette Cina Guy Bodenmann 《Journal of child and family studies》2016,25(3):798-810
The significance of enhancing parenting skills to reduce child maladjustment is well-established and supports the important role of evidence-based parenting programs. However, the notion that parenting should be the exclusive focus for enhancing child behavior is necessarily limiting. Evidence is growing that relationship-oriented treatments may be another powerful approach to improve child adjustment, albeit the underlying effects in couple- versus parenting-focused programs have been subject to limited study. The aim of this RCT was to compare the treatment effects of (1) a couple-focused program (the Couples Coping Enhancement Training) to (2) a parenting training (Triple P) and (3) a control group on children’s behavioral problems in 150 couples. The parents’ perceptions of relationship quality, parenting behavior, and child’s behavioral problems were assessed by means of questionnaires completed prior to and 2 weeks after the end of the treatment. Multi-group path analyses revealed that in mothers’ perception the couple-focused program reduced child behavioral problems by enhancing the relationship quality whereas improved parenting mediated the benefits in the parenting training. In fathers’ evaluations the couple-focused program reduced dysfunctional parenting which largely accounted for the benefits in child adjustment. The dearth of research on child outcomes in couple-focused intervention studies is a striking gap that should be overcome. It is a promising field because of its evident potential to foster the health of many children. 相似文献
74.
Amy Strickler Jennifer R. Mihalo Matthew J. Bundick Annette C. Trunzo 《Journal of child and family studies》2016,25(6):1860-1870
There is a need to evaluate the effectiveness of residential treatment centers (RTCs) due to scrutiny around use of this service that is viewed as costly, restrictive, and has resulted in mixed outcome results for youth. Discrepancies exist in residential literature regarding the amount of time in treatment that is optimal for having a positive effect on youth outcomes. This study used archival data to examine the relationship between time in treatment and youth’s improvement in functioning and restrictiveness of living environment in a cross-site evaluation of a large sample of youth (N = 716) who discharged from RTCs over a 5 year time period. Researchers aimed to identify an ideal time in treatment that is beneficial for youth and to add to the practice-based evidence for the effectiveness of RTCs. Results of segmented regression analyses indicate a non-linear relationship that showed a longer time in treatment predicts improvement in overall functioning and restrictiveness of living environment during the first 6 months of treatment. However there is no relationship between time in treatment and outcome variables between 6 and 10 months, and a negative relationship exists between longer time in treatment and outcome variables after 10 months in treatment. Practical implications of results can be used to inform advocacy efforts, discharge planning, and return on investment calculations. 相似文献
75.
76.
Yvonne Otto Katja Kolmorgen Susan Sierau Steffi Weis Kai von Klitzing Annette M. Klein 《Journal of child and family studies》2016,25(2):381-395
This study investigated parenting behaviors of mothers and fathers of clinically anxious preschool children (with or without depressive comorbidity) and healthy comparison children. Studies assessing children from early school age onwards have found that parental control, rejection, and inconsistent discipline are associated with the presence of children’s internalizing symptoms/disorders. Despite the scarcity of studies investigating these associations at preschool age, we assumed that findings with older children would also apply to children in this age group. In a cross-sectional study we assessed N = 176 children of preschool age (M = 5; 2 years) and both of their parents. A diagnostic interview (Preschool Age Psychiatric Assessment) was conducted to determine children’s psychiatric diagnoses, yielding the following results: a group of n = 67 children with pure anxiety disorders (AD group), a group of n = 38 children with anxiety disorders with depressive comorbidity (AD/DC group), and a comparison group of n = 71 children without psychiatric disorders. Both parents completed the German extended version of the Alabama Parenting Questionnaire. We evaluated maternal depressive symptoms and children’s temperament as further correlates. All variables that differed significantly between groups were entered into multinomial logistic regression analyses to test which variables predict group membership. When comparing each of the two anxiety groups with the comparison group we obtained the following results: (1) Inconsistent paternal discipline and maternal depressive symptoms increased and children’s positive affectivity decreased the probability of children of being in the AD group rather than in the comparison group. (2) Maternal overinvolvement, maternal depressive symptoms and children’s negative affectivity increased and children’s positive affectivity decreased the probability of children of belonging to the AD/DC group rather than to the comparison group. When comparing the two anxiety groups with each other, we found that inconsistent paternal discipline increased and children’s negative affectivity decreased the probability of children of being in the AD group rather than in the AD/DC group. The results suggest that paternal parenting behaviors show different associations with internalizing disorders at preschool age than maternal parenting behaviors. This underlines the importance of including fathers in the prevention and treatment of internalizing disorders at preschool age. 相似文献
77.
Annette Streeck-Fischer 《Forum der Psychoanalyse》2016,32(2):165-180
The process of identity formation as a central task of adolescence is difficult and fragile but even more so in adolescents with a migration background. Confronted with adverse experiences, cultural peculiarities of the country of origin can aggravate the second individuation phase of the adolescent, superimposed by a third phase caused by migration (Blos, Ahktar). With three case reports of mentally disturbed adolescents from different migration backgrounds, some specific dangers of such borderland adolescents are presented. All three cases have something in common: the importance of the glorified militant ideologies of the country of origin influencing the mental disorder of the adolescent in a special way such as a suitable target of narcissistic self-aggrandizement. The dangers of diagnostic colonization of alien symptoms and reactivation of elements of the Nazi past into the present with offender-victim constellations triggered by alienation are pointed out and discussed. The inability to draw borderlines between reality and fantasy and transmissive and deposed conflicts are described. 相似文献
78.
Annette L. Kennedy 《Journal of genetic counseling》2000,9(5):391-397
With the stage set by the overview of supervision models in the previous paper, thispaper now presents the development and evolution of a currently ongoing leader-ledsupervision group for experienced genetic counselors. I discuss the procedures forgetting started; the creation and maintenance of the contract; typical issues and themesconsidered; the format for case presentation; and the overall growth of the group and itsmembers. 相似文献
79.
Andrew Oliver Mark H. Johnson Annette Karmiloff‐Smith Bruce Pennington 《Developmental science》2000,3(1):1-23
A common way of studying developmental disorders is to adopt a static neuropsychological deficit approach, in which the brain is characterized in terms of a normal brain with some parts or ‘modules’ impaired. In this paper we outline a neuroconstructivist approach in which developmental disorders are viewed as alternative developmental trajectories in the emergence of representations within neural networks. As a concrete instantiation of the assumptions underlying this general approach, we present a number of simulations in an artificial neural network model. The representations that emerge under different architectural, input and developmental timing conditions are then analysed within a multi‐dimensional state space. We explore alternative developmental trajectories in these simulations, demonstrating how initial differences in the same parameter can lead to very different outcomes, and conversely how different starting states can sometimes result in similar end states (phenotypes). We conclude that the assumptions of the neuroconstructivist approach are likely to be more appropriate for analysing developmental deviations in complex dynamic neural networks, such as the human brain. 相似文献
80.
Specialization of the motor system in infancy: from broad tuning to selectively specialized purposeful actions 下载免费PDF全文
Hana D'Souza Dorothy Cowie Annette Karmiloff‐Smith Andrew J. Bremner 《Developmental science》2017,20(4)
In executing purposeful actions, adults select sufficient and necessary limbs. But infants often move goal‐irrelevant limbs, suggesting a developmental process of motor specialization. Two experiments with 9‐ and 12‐month‐olds revealed gradual decreases in extraneous movements in non‐acting limbs during unimanual actions. In Experiment 1, 9‐month‐olds produced more extraneous movements in the non‐acting hand/arm and feet/legs than 12‐month‐olds. In Experiment 2, analysis of the spatiotemporal dynamics of infants’ movements revealed developmental declines in the spatiotemporal coupling of movements between acting and non‐acting arms. We also showed that the degree of specialization in infants’ unimanual actions is associated with individual differences in motor experience and visual attention, indicating the experience‐dependent and broad functional nature of these developmental changes. Our study provides important new insights into motor development: as in cognitive domains, motor behaviours are initially broadly tuned to their goal, becoming progressively specialized during the first year of life. 相似文献