Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates

Previous studies of autobiographical memory (AM) in schizophrenia yielded a reduction of specificity, richness of details and conscious recollection, which indicate both, quantitative and qualitative AM changes. However, their associations with psychopathological symptoms and neuropsychological deficits were not resolved. Therefore, we sought to investigate AM with respect to psychopathology and neuropsychology in patients with chronic schizophrenia to rule out the influence of different courses of the disease. AM of four lifetime periods was examined in 75 patients and 50 healthy controls by using a semi-structured interview. The recalled episodes were rated for memory specificity. Subsequently, one single event of each period of life was rated for details and experiential aspects of reliving (originality, vividness/visual imagery, emotional re-experiencing and emotional valence). When contrasted with healthy controls, patients recalled a significantly reduced number of episodes and personal semantic facts; moreover, memory specificity of AM was significantly lower in patients than controls. While the richness of details calculated for single events showed only minor, non-significant group differences, vividness and emotional re-experiencing were significantly less pronounced in the patient group. Along with this, AM performance correlated significantly with negative symptoms including apathy as well as verbal memory and executive functions. Our results underline the significance of overgenerality as a key feature of AM in schizophrenia as well as a dissociation between intact number of details of single events and reduced vividness and emotional re-experiencing. The extent of negative symptoms including apathy and impairments of verbal memory/executive functions may explain AM deficits in chronic schizophrenia.     

Factor analysis by generalized least squares

Aitken's generalized least squares (GLS) principle, with the inverse of the observed variance-covariance matrix as a weight matrix, is applied to estimate the factor analysis model in the exploratory (unrestricted) case. It is shown that the GLS estimates are seale free and asymptotically efficient. The estimates are computed by a rapidly converging Newton-Raphson procedure. A new technique is used to deal with Heywood cases effectively.The work on this project was done when the first author was Research Statistician at Educational Testing Service, Princeton, N. J. The second author was in part supported by a grant from the Research Committee of the University of Wisconsin Graduate School. The authors wish to thank Michael Browne for many helpful comments and Marielle van Thillo for valuable assistance in the numerical computations.     

An individual difference model for the multidimensional analysis of preference data

A model for the analysis of paired comparison data is presented which combines features of the BTL-model with features of the Unfolding model. The model is metric, mathematically tractable, and has an exact algebraic solution. Since it is multidimensional and allows for individual differences, it is thought to be more realistic for some choice situations than either the Thurstone model or the BTL-model. No claim is made that the present model will be appropriate for all conceivable choice situations. Rather, it is argued that the fact that it is explicitly falsifiable is a point in its favor.This work was supported by a grant of the United States Public Health Service (1 R03 MH19139 01 MSM) and a David Ross (XR) grant of the Purdue Research Foundation (PRF 2132), both of which are gratefully acknowledged. We also owe thanks to Dr. Terry Cooper, whose careful scrutiny of an earlier draft of this paper allowed us to reduce the number of errors from n to n-1.     

Some new results on factor indeterminacy

Some relations between maximum likelihood factor analysis and factor indeterminacy are discussed. Bounds are derived for the minimum average correlation between equivalent sets of correlated factors which depend on the latent roots of the factor intercorrelation matrix . Empirical examples are presented to illustrate some of the theory and indicate the extent to which it can be expected to be relevant in practice.     

Negation of Park's transformations

Zusammenfassung Parks Kritik beruht, meiner Ansicht nach, auf einem entscheidenden Mißverständnis meiner Intentionen: es geht mir überhaupt nicht um eine Argumentation gegen eine Transformationsgrammatik à la Chomsky, und nicht einmal in erster Linie gegen die Absicht mancher Psycholinguisten, eine derartige Theorie in ihren psychischen Funktionen aufzuzeigen. Ich möchte lediglich dafür plädieren, daß die Psycholinguistik in erster Linie psychologische (und nicht linguistische) Überlegungen und Modellvorstellungen als Leitlinien verwendet.     

A general approach to confirmatory maximum likelihood factor analysis

We describe a general procedure by which any number of parameters of the factor analytic model can be held fixed at any values and the remaining free parameters estimated by the maximum likelihood method. The generality of the approach makes it possible to deal with all kinds of solutions: orthogonal, oblique and various mixtures of these. By choosing the fixed parameters appropriately, factors can be defined to have desired properties and make subsequent rotation unnecessary. The goodness of fit of the maximum likelihood solution under the hypothesis represented by the fixed parameters is tested by a large samplex ² test based on the likelihood ratio technique. A by-product of the procedure is an estimate of the variance-covariance matrix of the estimated parameters. From this, approximate confidence intervals for the parameters can be obtained. Several examples illustrating the usefulness of the procedure are given.This work was supported by a grant (NSF-GB 1985) from the National Science Foundation to Educational Testing Service.     

A method for sensation scaling based on an analogy between perception and judgment

Two techniques for studying judgment are discussed. In the first of these one assumes invariance of perception over different judgment processes and conceives of the properties of one judgment process as known. Then, perceptions may be estimated under this process and utilized in the study of other judgment processes of interest. A second technique disposes of the reliance up on a basic, “known” process and instead suggests that perception be treated as free parameters to be estimated from data. The paper then proceeds to show how this second technique may be used under certain conditions on perception themselves. A concept of sensation is introduced which is thought of as generating percepts in formally the same manner as percepts are thought of as generating judgments. The idea is tried out on the perception of movement time. A simple perception process appears to give a good fit to data.     

The importance of a holistic concept of health for health care. Examples from the clinic

One of my main points in this study is that the knowledge of orthodox medical theory is an incomplete guide for practical action when relating to our patients' specifically human problems. By following a holistic perspective on patients' health and on our medical enterprise we will be more efficient as doctors. This standpoint is illuminated by means of two case reports. Instead of focusing on symptoms as such and letting them refer to orthodox medical theory, I explicitly relate to the patients as if they are conveying a personal meaning by means of experienced symptoms. The experience of illness could be a successful strategy on the existential level although destructive on the technical biological level. A holistic theory of health can give doctors a good conceptual base when relating to people whose presented illnesses are to be regarded explicitly as their way of making themselves understood. The doctor's understanding of the patient's illness, of the theory of health, and of how health is regained, is dependent on the doctor's having the courage to reduce the distance to the patient, the courage to participate and be changed.     

Psychophysiological and behavioral differences as a function of age and Parkinson’s disease

Differences related to age and to specific neurological (Parkinsonian) damage were studied by contrasting, respectively, old (mean age 64 years) and young (27 years) subjects (N=15), and old-normal (N=15) and old-Parkinsonian (N=15) subjects. Both behavioral as well as psychophysiological dependent variables were employed. The behavioral measure was performance on a discrimination learning task, while the psychophysiological measures were based on habituation to a repeated tone stimulus and on a Pavlovian differential conditioning preparation. The behavioral task showed predominantly age-related differences, with the young learning faster. Another age-related difference was interpreted as showing a more insight-like learning process in the young. Response-bias (beta) values did not differ between groups. Age-related differences also emerged more clearly than specific-neurological-damage differences in the psychophysiological data. The older subjects manifested markedly less autonomic conditioning, which was probably due to a lowering of reactivity, as well as the emergence of habituation to the (loud-noise) unconditional stimulus. A correlational analysis of discrimination conditioning also yielded age-related differences. Most notably, reactivity played a greater role in conditioning in the old than in the young subjects. The results illustrated how psychophysiological measures can provide information that complements those provided by behavioral measures.