Autobiographical memory impairment in chronic schizophrenia: Significance and clinical correlates

Previous studies of autobiographical memory (AM) in schizophrenia yielded a reduction of specificity, richness of details and conscious recollection, which indicate both, quantitative and qualitative AM changes. However, their associations with psychopathological symptoms and neuropsychological deficits were not resolved. Therefore, we sought to investigate AM with respect to psychopathology and neuropsychology in patients with chronic schizophrenia to rule out the influence of different courses of the disease. AM of four lifetime periods was examined in 75 patients and 50 healthy controls by using a semi-structured interview. The recalled episodes were rated for memory specificity. Subsequently, one single event of each period of life was rated for details and experiential aspects of reliving (originality, vividness/visual imagery, emotional re-experiencing and emotional valence). When contrasted with healthy controls, patients recalled a significantly reduced number of episodes and personal semantic facts; moreover, memory specificity of AM was significantly lower in patients than controls. While the richness of details calculated for single events showed only minor, non-significant group differences, vividness and emotional re-experiencing were significantly less pronounced in the patient group. Along with this, AM performance correlated significantly with negative symptoms including apathy as well as verbal memory and executive functions. Our results underline the significance of overgenerality as a key feature of AM in schizophrenia as well as a dissociation between intact number of details of single events and reduced vividness and emotional re-experiencing. The extent of negative symptoms including apathy and impairments of verbal memory/executive functions may explain AM deficits in chronic schizophrenia.     

The nature of adaptation in distance perception based on oculomotor cues

In previous work by the senior authors, brief adaptation to glasses that changed the accommodation and convergence with which objects were seen resulted in large alterations in size perception. Here, two further effects of such adaptation are reported: alterations in stereoscopic depth perception and a change when distance is represented by a response of S’s arm. We believe that the three effects are manifestations of one primary effect, an alteration of the relation between accommodation and convergence on the one hand and the distance they represent in the nervous system (registered distance) on the other. This view was supported by the results of two experiments, each of which demonstrated that the alterations in stereoscopic depth perception could be obtained after adaptation periods which had provided no opportunity to use stereoscopic vision, and that the adaptation effect was larger for depth perception than for size perception when it was obtained under the same conditions; the latter finding was expected if both effects resulted from the same change in registered distance. In three of the five experiments here reported, the variety of cues that could represent veridical distance during the adaptation period was limited. In one condition of adaptation, only the pattern of growth of the retinal images of objects that S approached and the kinesthetic cues for S’s locomotion served as cues to veridical distance. In two other conditions S remained immobile. In one of these, only the perspective distortion in the projection of the scene that S viewed mediated veridical distance, and in the other one familiar objects of normal size were successively illuminated in an otherwise totally dark field, conditions from which opportunities to use stereoscopic vision were again absent. After exposure to each of these adaptation conditions, adaptive changes in perceived size and larger ones in perceived stereoscopic depth were obtained. Because we found that familiar size may serve as the sole indicator of veridical distance in an adaptation process, we concluded that it can function as a perceptual as distinguished from an inferential cue to distance.     

Increased eating in rats deprived of running

Daily food intake in rats was temporarily reduced by the introduction of an activity wheel and temporarily increased by the subsequent removal of the wheel. When this outcome is coupled with the positive relation between food deprivation and running—and food deprivation is seen as a loss of eating rather than as a physiological state—there is the suggestion that the total behavior output of the organism may be regulated as such. Specifically, when the rat is deprived of a behavior that recurrently comprises a large part of its total daily activity, an increase may occur in some other behavior.     

An individual differences model for multiple regression

A model for multiple regression was developed which allows individual differences to emerge empirically. The model encompasses as special cases several of the previous attempts to improve psychological prediction by deviating from the usual linear multiple regression model. The model is tested with both artificial and real data. The results indicate that the model effectively reduces the variance of the error of prediction, and that the weights obtained are stable over different samples, and, to some extent, over different sets of predictors.This article is based upon a thesis submitted in partial fulfillment of the requirements for the doctoral degree at the University of Illinois. The author thanks Professor Ledyard R Tucker who served as committee chairman and offered considerable support and assistance.     

Anxiety and the spelling and use in sentences of threat/neutral homophones

The disambiguation of threat/neutral homophones was investigated in high- and low-trait anxiety subjects who had been exposed to either a positive or a negative mood manipulation procedure. Subjects were required first to spell each auditorily presented word and second, to generate and speak a sentence using the word. Difference indices were calculated for the spelling and the sentence usage data, i.e. the number of threat minus neutral interpretations. Examination of these indices revealed that subjects exposed to the negative mood manipulation procedure produced relatively more threat than neutral interpretations (for both spelling and sentence usage) than did subjects exposed to the positive mood manipulation procedure. Multiple regression analyses revealed that both the trait anxiety and mood manipulation variables contributed significantly to the prediction of the difference index on the spelling task. In the analysis of the use of homophones in sentences, only the mood manipulation variable contributed significantly to the prediction of the difference index on the sentence usage task.     

Family psychopathology: Cross training graduate marital and family therapy students in family assessment and psychiatric nosology

The structure of a course entitled Family Therapy with Major Psychopathology taught annually in the Mercer University Graduate Marriage and Family Therapy Program is presented. An epistemological presentation regarding the interface of psychiatric nosology and family systems assessment is discussed. Methods of diagnosing and assessing dysfunctional family systems are presented and training in individual psychiatric nosology is discussed, with particular attention given to family systems dysfunction as an etiological factor in the development of individual psychopathology. Learning techniques are discussed including lecture, discussion, case presentations, readings, and testing methods.     

INCREASING CALORIE CONSUMPTION IN CHILDREN WITH CYSTIC FIBROSIS: REPLICATION WITH 2-YEAR FOLLOW-UP

Three mildly malnourished children with cystic fibrosis and their parents participated in a behavioral group-treatment program that focused on promoting and maintaining increased calorie consumption. Treatment included nutritional education, gradually increasing calorie goals, contingency management, and relaxation training, and was evaluated in a multiple baseline design across four meals. Children's calorie intake increased across meals, and total calorie intake was 32% to 60% above baseline at posttreatment. Increased calorie consumption was maintained at the 96-week follow-up (2 years posttreatment). The children's growth rates in weight and height were greater during the 2 years following treatment than the year prior to treatment. Increases in pace of eating and calories consumed per minute were also observed 1 year posttreatment. These findings replicated and extended earlier research supporting the efficacy of behavioral intervention in the treatment of malnutrition in children with cystic fibrosis.