Endogenous opioids, blood pressure, and diffuse noxious inhibitory controls: a preliminary study

A 2003 study suggested that there are age differences in diffuse noxious inhibitory controls (DNIC), a form of endogenous pain inhibition. The present report describes a followup study employing a pharmacological blockade of endogenous opioids, i.e., using naloxone, in a small subset (n=6) of healthy young volunteers to characterize the opioid-dependence of DNIC, as well as DNIC's association with cardiovascular reactivity. Findings suggested that, while opioid blockade enhanced cardiovascular reactivity to cold pain, DNIC was not affected by administering naloxone. Interestingly, greater cardiovascular responses to noxious cold were associated with enhanced DNIC in this small sample. This relationship, which did not appear opioid-dependent, supports previous models integrating cardiovascular activity with the functioning of pain-modulatory systems.     

The Validation of a Five-Item Screening Scale for Personality Disorders in Dutch-Speaking Community Adolescents and Adults

In Section III of the Diagnostic and Statistical Manual of Mental Disorders – fifth edition (DSM-5), an Alternative Model for Personality Disorders (AMPD) is proposed, including a criterion for personality functioning impairment (Criterion A) to assess severity of personality pathology. The present study examined the structure, reliability, and convergent validity of the Dutch version of a five-item screening scale for Criterion A—the Five-Item Screening Scale for Personality Disorders (FISSPD; Skodol et al., in Personality Disorders: Theory, Research, and Treatment, 2, 4-22, 2011)—in a community sample of 1,477 adolescents and 546 adults. To assess convergent validity, identity and personality (pathology) questionnaires were completed by adolescents and adults. Confirmatory factor analysis yielded a single factor structure for the FISSPD, which proved to be (partially) invariant across age and gender. Adequate reliability coefficients were obtained for the FISSPD. In both the adolescent and adult sample, significant correlations were found between the FISSPD and consolidated identity (negative) and disturbed identity/lack of identity (positive). In the adult sample, the FISSPD showed significant correlations with several personality disorders (and especially with the borderline personality disorder), maladaptive personality traits (Criterion B of the AMPD), and general personality impairment. In the adolescent sample, the FISSPD was positively correlated with borderline personality disorder characteristics. Furthermore, significant correlations were found with the Big-Five personality traits in the adolescent sample: the FISSPD correlated significantly positive with neuroticism, and negative with extraversion, agreeableness, and conscientiousness. In sum, the present study supports the reliability and validity of the FISSPD to screen for (severity of) personality pathology.

     

Language-specific Knowledge and Short-term Memory in Bilingual and Non-bilingual Children

The sensitivity of children's phonological short-term memory performance to languagespecific knowledge was investigated in two experiments. In Experiment 1, monolingual English children, English-French bilingual children, and English children who were learning French as a second language were compared on measures of phonological short-term memory and vocabulary in the two languages. The children's short-term memory performance in each language mirrored their familiarity with English and French, with greater vocabulary knowledge being associated with higher levels of recall of both words and nonwords in that language. This finding was replicated in Experiment 2, in which two groups of children with good knowledge of English and French were examined: native bilingual children who had comparable knowledge of the two languages and non-native bilingual children who had a greater knowledge of their native than second language. The findings indicate that phonological short-term memory is not a language-independent system but, rather, functions in a highly language-specific way.