A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults With ADHD

Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for adult ADHD. Method: A randomized, double-blind, placebo-controlled, crossover study was conducted in adults with primary ADHD. The primary end point was changed from baseline in total score on the Adult ADHD Investigator Symptom Rating Scale following a 4-week treatment regimen. Additional measures included Clinical Global Impression-Severity Scale, Hospital Anxiety and Depression Scale, and Brown Attention Deficit Disorder Scale and D4 genotype analysis. Results: No statistically significant treatment differences were found between MK-0929 and placebo in any of the primary or secondary assessments. Conclusion: Results from this study suggest that blockade of the D4 receptor alone is not efficacious in the treatment of adult ADHD.     

Motor proficiency and emotional/behavioural disturbance in autism and Asperger's disorder: another piece of the neurological puzzle?

The relationship of motor proficiency with emotional/behavioural disturbance, autistic symptoms and communication disturbance was investigated in children diagnosed with autism and Asperger's disorder (AD). The Movement Assessment Battery for Children was used as a measure of motor impairment, and the Developmental Behavioural Checklist was used as a measure of emotional/behavioural disturbance in the following groups: AD (n?=?22), high functioning autism (HFA) (n?=?23), LFA (n?=?8) and typically developing children (n?=?20). The HFA group had more difficulty with motor items, such as ball skills and balance, than did the AD group. There were significant positive correlations between impairments in motor proficiency (in particular ball skills and balance) and emotional/behavioural disturbance, autistic symptoms and communication disturbance. These findings are consistent with the hypothesis that there are qualitative and quantitative differences in the motor profile between autism and AD. In addition, the association between motor proficiency impairment and emotional/behavioural disturbance in autism and AD emphasizes the importance for screening of co-occurring emotional/behavioural symptoms in individuals with motor difficulties. These findings have implications for the potential use of adjunct motor measures in the diagnosis and definition of autism spectrum disorders.     

Modeling body state-dependent multisensory integration

The brain often integrates multisensory sources of information in a way that is close to the optimal according to Bayesian principles. Since sensory modalities are grounded in different, body-relative frames of reference, multisensory integration requires accurate transformations of information. We have shown experimentally, for example, that a rotating tactile stimulus on the palm of the right hand can influence the judgment of ambiguously rotating visual displays. Most significantly, this influence depended on the palm orientation: when facing upwards, a clockwise rotation on the palm yielded a clockwise visual judgment bias; when facing downwards, the same clockwise rotation yielded a counterclockwise bias. Thus, tactile rotation cues biased visual rotation judgment in a head-centered reference frame. Recently, we have generated a modular, multimodal arm model that is able to mimic aspects of such experiments. The model co-represents the state of an arm in several modalities, including a proprioceptive, joint angle modality as well as head-centered orientation and location modalities. Each modality represents each limb or joint separately. Sensory information from the different modalities is exchanged via local forward and inverse kinematic mappings. Also, re-afferent sensory feedback is anticipated and integrated via Kalman filtering. Information across modalities is integrated probabilistically via Bayesian-based plausibility estimates, continuously maintaining a consistent global arm state estimation. This architecture is thus able to model the described effect of posture-dependent motion cue integration: tactile and proprioceptive sensory information may yield top–down biases on visual processing. Equally, such information may influence top–down visual attention, expecting particular arm-dependent motion patterns. Current research implements such effects on visual processing and attention.     

On the recognition of emotional vocal expressions: motivations for a holistic approach

Human beings seem to be able to recognize emotions from speech very well and information communication technology aims to implement machines and agents that can do the same. However, to be able to automatically recognize affective states from speech signals, it is necessary to solve two main technological problems. The former concerns the identification of effective and efficient processing algorithms capable of capturing emotional acoustic features from speech sentences. The latter focuses on finding computational models able to classify, with an approximation as good as human listeners, a given set of emotional states. This paper will survey these topics and provide some insights for a holistic approach to the automatic analysis, recognition and synthesis of affective states.     

Linguistic labels: Conceptual markers or object features?

Linguistic labels affect inductive generalization; however, the mechanism underlying these effects remains unclear. According to one similarity-based model, SINC (similarity, induction, naming, and categorization), early in development labels are features of objects contributing to the overall similarity of compared entities, with early induction being similarity based. If this is the case, then not only identical but also phonologically similar labels may contribute to the overall similarity and thus to induction. These predictions were tested in a series of experiments with 5-year-olds and adults. In Experiments 1-5 participants performed a label extension task, whereas in Experiment 6 they performed a feature induction task. Results indicate that phonological similarity contributes to early induction and support the notion that for young children labels are features of objects.     

Domestic dogs (Canis familiaris) and the radial arm maze: Spatial memory and serial position effects

The present study investigated spatial memory in domestic dogs (Canis familiaris) through the use of a radial arm maze. The study consisted of a total of three separate experiments. In the first two experiments, the ability of the dogs to successfully remember previously unentered arms was evaluated. The third experiment was similar to the first two, but also examined the nature of the serial position effect. Performance in all three experiments was better than expected solely by random choices. Dogs showed a much better memory for spatial locations presented earlier in a spatial list compared with those presented in the middle. Based on the present results, we suggest that the radial arm maze assesses canine spatial memory and that dogs show a primacy effect. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Instruction-in-Interaction: The Teaching and Learning of a Manual Skill

This study takes an interest in instructions and instructed actions in the context of manual skills. The analysis focuses on a video recorded episode where a teacher demonstrates how to crochet chain stitches, requests a group of students to reproduce her actions, and then repeatedly corrects the attempts of one of the students. The initial request, and the students’ responses to it, could be seen as preliminary to the series of corrective sequences that come next: the request and the following attempts make it possible for the teacher to launch instructional sequences specifically designed and addressed to the students who need further guidance. In the interaction between the teacher and the novice student, the reasoned character of the instructed actions is not explained so much as installed and tuned. The materiality of the project makes it possible for the two parties to methodically and meticulously adjust their actions in accordance with each other, and towards the gradual realization of the aimed-for results. In connection to this, a number of issues pertaining to the reproducibility and recognizability of manual skills are raised: how instructions-in-interaction orient towards the progression of the skill rather than the interaction itself; how attempts by and mistakes of the instructed party provide grounds for further instruction; and, consequently, how instructions in the form of corrections build on the instructor’s continuous assessments of the instructed actions.     

Measurement invariance and age-related differences of trait anger across the adult lifespan

The present study examined measurement invariance of trait anger with respect to age. In addition, age-related differences in latent variables (factor variances, factor covariances, and factor means) were investigated. A sample of 1216 participants, divided into six age groups, ranging from under 30 to over 70 years, was tested using the angry temperament and angry reaction scales from the State-Trait Anger Expression Inventory (STAXI; Spielberger, 1988). Results show that strong measurement invariance held across the six age groups. For both angry temperament and angry reaction, factor variances tended to decrease into middle age and then increase again into old age. Factor correlations decreased into old age, implying a differentiation of trait anger. Finally, regarding factor means, older adults showed less anger than younger adults, suggesting higher levels of self-regulation or less exposure to anger-provoking contexts in later life.     

Positive Traits Linked to Less Pain through Lower Pain Catastrophizing

The present study examined the association between positive traits, pain catastrophizing, and pain perceptions. We hypothesized that pain catastrophizing would mediate the relationship between positive traits and pain. First, participants (n = 114) completed the Trait Hope Scale, the Life Orientation Test-Revised, and the Pain Catastrophizing Scale. Participants then completed the experimental pain stimulus, a cold pressor task, by submerging their hand in a circulating water bath (0 °C) for as long as tolerable. Immediately following the task, participants completed the Short-Form McGill Pain Questionnaire (MPQ-SF). Pearson correlation found associations between hope and pain catastrophizing (r = −.41, p < .01) and MPQ-SF scores (r = −.20, p < .05). Optimism was significantly associated with pain catastrophizing (r = −.44, p < .01) and MPQ-SF scores (r = −.19, p < .05). Bootstrapping, a non-parametric resampling procedure, tested for mediation and supported our hypothesis that pain catastrophizing mediated the relationship between positive traits and MPQ-SF pain report. To our knowledge, this investigation is the first to establish that the protective link between positive traits and experimental pain operates through lower pain catastrophizing.