Contextual conditioning in rats as an animal model for generalized anxiety disorder

Animal models of psychiatric disorders are important translational tools for exploring new treatment options and gaining more insight into the disease. Thus far, there is no systematically validated animal model for generalized anxiety disorder (GAD), a severely impairing and difficult-to-treat disease. In this review, we propose contextual conditioning (CC) as an animal model for GAD. We argue that this model has sufficient face validity (there are several symptom similarities), predictive validity (it responds to clinically effective treatments), and construct validity (the underlying mechanisms are comparable). Although the refinement and validation of an animal model is a never-ending process, we want to give a concise overview of the currently available evidence. We suggest that the CC model might be a valuable preclinical tool to enhance the development of new treatment strategies and our understanding of GAD.     

A model for removing the increased recall of recent events from the temporal distribution of autobiographical memory

The reminiscence bump is the tendency to recall relatively many personal events from the period in which the individual was between 10 and 30 years old. This effect has only been found in autobiographical memory studies that used participants who were older than 40 years of age. The increased recall of recent events possibly obscures the reminiscence bump in the results of younger participants. In this study, a model was proposed that removes the increase for recent events from the temporal distribution. The model basically estimates a retention function based on the 10 most recent years from the observed distributions and divides the observed distributions by predictions derived from the estimated retention function. The model was examined with three simulated data sets and one experimental data set. The results of the experiment offered two practical examples of how the model could be used to investigate the temporal distribution of autobiographical memories.     

Media exposure, internalization of the thin ideal, and body dissatisfaction: comparing Asian American and European American college females

Internalization of the thin ideal mediates the media exposure-body dissatisfaction relation in young adult European American females. There is little related research on Asian Americans. We used structural equations modeling to test: (1) whether media exposure was associated with body dissatisfaction in Asian American young adult females, (2) internalization of the thin ideal mediated any such association, and (3) whether the mediational model provided equivalent fit for European American and Asian American samples. Participants were 287 college females (154 Asian Americans, 133 European Americans). Internalization of the thin ideal explained the media exposure-body dissatisfaction association equally well for both groups. Results suggest that Asian Americans may be employing unhealthy weight control behaviors, and may be prone to developing eating disorders, at rates similar to European American young adult females. Clinicians need to screen carefully for body dissatisfaction, unhealthy weight control behaviors, and eating disorders in Asian American females.     

Virtual conversation partner for adults with autism

Autistic Spectrum Disorder (ASD) is notable for severely impaired reciprocal social interaction skills relative to language and intellectual abilities, presenting a major barrier to social integration and vocational success. Evidence-based interventions to address these needs are lacking. We report on the development of a small, prototype conversation simulation to teach conversational skills to adolescents and adults with ASD and average to superior intellectual abilities. We also report on a test of the feasibility and acceptability of the simulation approach with a sample of the target population. The simulation engages the user in a virtual conversation with an on-screen partner whose reactions provide naturalistic feedback geared to the appropriateness of the learner's response choices. The prototype simulation, which provides for up to 12 potentially unique multi-turn conversations, was used over a period of 2 weeks by 16 adolescents and adults who then rated statements about the system on a linear scale of 1 (disagreement) to 5 (high agreement). The participants highly endorsed the majority of positive statements about the quality and credibility of the interaction and the virtual conversation partner. In contrast, agreement with positive statements about instructional features external to the conversation was moderate. Unexpectedly, most participants strongly agreed that using the simulation had been helpful to them. Further development and testing in the context of a controlled study with randomized assignment to control and experimental groups are needed to determine whether this approach is effective in improving real-world pragmatic language behavior of high-functioning adults with ASD.     

Action-induced effects on perception depend neither on element-level nor on set-level similarity between stimulus and response sets

As was shown by Wykowska, Schubö, and Hommel (Journal of Experimental Psychology, Human Perception and Performance, 35, 1755–1769, 2009), action control can affect rather early perceptual processes in visual search: Although size pop-outs are detected faster when having prepared for a manual grasping action, luminance pop-outs benefit from preparing for a pointing action. In the present study, we demonstrate that this effect of action–target congruency does not rely on, or vary with, set-level similarity or element-level similarity between perception and action—two factors that play crucial roles in standard stimulus–response interactions and in models accounting for these interactions. This result suggests that action control biases perceptual processes in specific ways that go beyond standard stimulus–response compatibility effects and supports the idea that action–target congruency taps into a fundamental characteristic of human action control.     

The role of encoding strategies in the verbal memory performance in patients with schizophrenia

Background. Verbal learning and memory is often compromised in patients with schizophrenia who prefer encoding words in order of their presentation (serial clustering) rather than using semantic categories (semantic clustering). Method. One hundred and four in‐patients with schizophrenia were assessed twice with the California Verbal Learning Test. Results. Patients showed significantly less semantic than serial clustering at both assessment times. Usage of encoding strategies were not stable over time. An increase in semantic clustering improved recall and recognition performance. Conclusions. Patients with schizophrenia should be taught to use the more effective encoding strategy of semantic clustering in order to improve their memory performance.     

The Longitudinal Relationship Between Satisfaction with Transitional Care and Social and Emotional Quality of Life Among Chronically Ill Adolescents

This study aimed to identify the relationship between satisfaction with transitional care and quality of life of chronically ill adolescents over time. This longitudinal study included adolescents with type I diabetes, juvenile idiopathic arthritis (JIA), and neuromuscular disorders (NMD). At baseline 138 respondents (response rate 31 %) filled in a questionnaire and 188 about 1 year later (response rate 43 %). Analysis of variance showed that adolescents with diabetes reported the highest physical quality of life, followed in order by those with NMD and JIA (p?≤?0.01). Adolescents with diabetes reported the highest social quality of life, followed in order by those with JIA and NMD (both at p?≤?0.001). Univariate analyses showed that satisfaction with transitional care at T0 was significantly related to emotional and physical quality of life at T1 (both at p?≤?0.05). At T1, satisfaction with transitional care was significantly related to the emotional, physical, and social domains of quality of life (all at p?≤?0.001). Multiple regression analyses revealed that satisfaction with transitional care at T1 was related to emotional (β -0.20; p?≤?0.05) and social (β -0.35; p?≤?0.01) quality of life domains over time. This indicates that lower gap scores, which measured differences between ‘best care’ and ‘current care,’ are associated with better social and emotional quality of life in this sample of adolescents. Satisfaction with transitional care and social and emotional quality of life are related over time.     

A Place for Individual Differences in What Everyone Knows About What Everyone Does: Positive Affect,Cognitive Processes,and Cognitive Experiential Self Theory

Individual differences are often incorporated into experimental research to elucidate inconsistent effects. We argue that the inclusion of such differences into established and seemingly straightforward findings is imperative to the goal of reaching a more complete understanding about the processes of interest. Drawing on research on the cognitive effects of positive affect, we illustrate how integrating individual differences in cognitive processing styles to this literature might lead to a more nuanced understanding of the impact of affect on cognitive processes. The addition of individual differences to psychological research should be seen as a means to a thorough scientific comprehension of a topic rather than as burdensome caveats to otherwise straightforward findings.     

Happy with a difference, unhappy with an identity: Observers’ mood determines processing depth in visual search

Visual search for feature targets was employed to investigate whether the mechanisms underlying visual selective attention are modulated by observers’ mood. The effects of induced mood on overall mean reaction times and on changes and repetitions of target-defining features and dimensions across consecutive trials were measured. The results showed that reaction times were significantly slower in the negative than in the positive and neutral mood groups. Furthermore, the results demonstrated that the processing stage that is activated to select visual information in a feature search task is modulated by the observer’s mood. In participants with positive or neutral moods, dimension-specific, but no feature-specific, intertrial transition effects were found, suggesting that these observers based their responses on a salience signal coding the most conspicuous display location. Conversely, intertrial effects in observers in a negative mood were feature-specific in nature, suggesting that these participants accessed the feature identity level before responding.