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111.
Darcq E Koebel P Del Boca C Pannetier S Kirstetter AS Garnier JM Hanauer A Befort K Kieffer BL 《Learning & memory (Cold Spring Harbor, N.Y.)》2011,18(9):574-578
RSK2 is a Ser/Thr kinase acting in the Ras/MAPK pathway. Rsk2 gene deficiency leads to the Coffin-Lowry Syndrome, notably characterized by cognitive deficits. We found that mrsk2 knockout mice are unable to associate an aversive stimulus with context in a lithium-induced conditioned place aversion task requiring both high-order cognition and emotional processing. Virally mediated shRNA-RSK2 knockdown in the habenula, whose involvement in cognition is receiving increasing attention, also ablated contextual conditioning. RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning. 相似文献
112.
Marini A Lorusso ML D'Angelo MG Civati F Turconi AC Fabbro F Bresolin N 《Brain and language》2007,102(1):1-12
The present work investigated cognitive, linguistic and narrative abilities in a group of children suffering from Duchenne Muscular Dystrophy, an allelic X-linked recessive disorder caused by mutations in the gene encoding dystrophin. The patients showed mildly reduced IQ with lower Verbal than Performance Intelligence Quotient and were mildly affected in visual attention and short-term memory processing. At the linguistic assessment, neither receptive (word comprehension) nor expressive (naming tasks and fluency) lexical abilities were impaired. However, their narratives were qualitatively inferior with respect to those produced by a group of typically developing children. Their speech samples were characterized by the presence of fewer verbs and complete sentences. It is suggested that the reduced production of complete sentences is due to a selective problem in verb argument structure generation. Since the lack of dystrophin is assumed to produce effects on the maturation of the cerebellum, whose involvement has been recently suggested in verb and syntactic processing, these findings may lend indirect support to the hypothesis of a cerebellar-cortical circuit specialized in verb and sentence production. 相似文献
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This study examined therapeutic outcome for a group of 175 clinic families divided into levels of family competence and style, and, later, into seven clinical groupings. The division into these groups was based on the level of rated Competence and Style determined by using the Beavers Systems Model. Therapists also rated their level of Openness/Sharing Strategy, Power Differential, and Partnership with the family at the third session. Results indicate that more competent families who fared well in therapy had therapists who formed a partnership, disclosed strategy, and employed a minimal power differential with the family. The most disturbed families, and those with a Centrifugal style, did better with therapists employing a high power differential and lower levels of openness and partnership. The study also presented the distribution of individual diagnoses by family groups. Implications for family therapists, including the value of family assessment, are provided. 相似文献
115.
Tatjana Sivik MD Ph.D. MA Domagoj Delimar MD Patricia Korenjak MD Natasa Delimar Ph.D. 《Integrative psychological & behavioral science》1997,32(4):364-372
Ninety soldiers with at least three months of combat exposure—60 injured soldiers (30 with permanent disabling and 30 with
nondisabling injuries), 30 noninjured soldiers and 30 healthy controls—were interviewed and investigated with physiological
(Prolactine, Cortisol, BP, Hb) and psychological tests (MMPI), IES-15 (Impact of Event Scale), PTSS (Post-Traumatic Symptom
Scale). Their was related injuries had a different effect on the physiological stress response of the soldiers as reflected
in the levels of prolactine, cortisol, hemoglobin and blood pressure.
In a report of personality characteristics of the same soldiers, we demonstrated that the experience of posttraumatic stress
was not dependent upon physical injury, but rather on the psychological appraisal of the situation. The results of the present
article confirm earlier findings that the relationship between physiological and psychological consequences of trauma are
complex, and that the perception of an event and the social context within which the traumatized soldier exists is as important
as the event itself. The physiological response to the trauma varied greatly among the soldiers regarding the psychosocial
impact of the consequence of the injury. So the anticipation of future possible trauma among less severely wounded soldiers
(expected to go back to war) was followed by pathological stress responses. Trauma seems to operate somewhat independently
from the overt conscious appraisal of the situation and relationship between psychological, psychosocial, and physiological
aspects are interrelated in a multifactorial way. An integrative approach is therefore of great importance in assessment as
well as in treatment of Posttraumatic Stress Disorder (PTSD).
Editorial Note This historical article is being published for the first time. It is based on the Ph.D. thesis of Dr. Harry
A. Teitelbaum for which he was awarded a doctorate by the University of Maryland in College Park in 1936. The dissertation
was stored prior to publication and was not rediscovered until 1997. Teitelbaum’s work was performed during the early days
of the development of knowledge regarding the mechanisms that regulate endocrine function. The understanding of the broad
capability of interactions among endocrine glands was evolving. It was a field that Teitelbaum contributed to for several
years, many of which were spent in collaboration with Horsley Gantt in his laboratory at Johns Hopkins. Although some of the
experimental strategies and some of the wording of the report seem quaint today, the contribution of Teitelbaum’s research
was solid and highly relevant to questions being asked at the time. 相似文献
116.
Alfredo A. Canevaro MD 《Contemporary Family Therapy》1990,12(2):105-114
The author presents a model for research investigation and clinical use that deals with the interaction between cohesive and dispersive family of origin systems as reflected in marital and family interaction in nuclear families.From a paper presented at the tenth annual meeting of the American Family Therapy Association, June, 1988, Montreal, PQ, Canada. 相似文献
117.
F R Brush S N Del Paine L J Pellegrino I M Rykaszewski N K Dess P Y Collins 《Journal of comparative psychology (Washington, D.C. : 1983)》1988,102(4):337-349
The Syracuse strains of Long-Evans rats were selectively bred for good (SHA) or poor (SLA) avoidance learning in a two-way shuttle box, which resulted in a phenotypic difference that is correlated with behavior patterns indicative of emotional reactivity, SLA animals showing evidence of greater emotional reactivity than SHA animals. The first three experiments examined conditioned suppression of bar pressing and compared paired and unpaired conditioned- and unconditioned-stimulus presentations to evaluate the influence of conditioning versus primary aversive stimulation on baseline responding. SLA animals acquired conditioned suppression faster than SHA animals and also showed greater suppression of baseline responding than SHA animals. In Experiment 4, SLA animals learned a passive-avoidance task faster than SHA animals. In Experiment 5, SLA animals showed greater stress-induced suppression of drinking a weak quinine solution than SHA animals. These data are consistent with the hypothesis that SLA animals are more emotionally reactive than SHA animals. 相似文献
118.
David V. Keith MD. 《Contemporary Family Therapy》1987,9(1-2):11-22
Intuition is an important part of a mature clinician's work. Yet, it is a component of clinical work which is looked upon with suspicion, due in part to the Middle-Age's association between intuition and the work of witches. This paper describes a tenuous link between intuition, witches, and Carl Whitaker. Patterns for including intuition in family therapy are discussed. 相似文献
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