Effects of neonatal cyproterone acetate administration on isolation-induced fighting behavior and mounting behavior in male and female TO strain albino mice

The effects of a single dose (1 mg) of cyproterone acetate administered on either day 1 or day 20 of life on the adult behaviors of male and female TO strain albino mice were studied. The mice were tested both in a “standard opponent”-type situation and in a similar test using a hormonally primed receptive female, after being gonadectomized and maintained with testosterone propionate as adults. Neonatal treatment with this compound had little effect on subsequent fighting behavior in either sex, but clear evidence was produced that this treatment masculinized the sexual behavioral potentialities of the females, an effect which was apparent in animals which had been injected on either day 1 or day 20 of life. Indications were obtained that females treated neonatally with cyproterone acetate were capable of differentiating between the male and female “opponents” in a manner similar to the male. The effects of this treatment on fighting behavior consequently appear to be dissimilar to the effects of neonatal castration in this species. However, the effects on mounting behavior in the females, evidenced in adulthood, seem Likely to be a consequence of the weak androgenic properties of the antiandrogen. The administration of cyproterone acetate neonatally appears to have a more dramatic effect on the adult weights of endocrine organs in females than in mates.     

The role of endocrines in isolation-induced intermale fighting in albino laboratory mice. I: PITUITARY-ADRENOCORTICAL INFLUENCES

Recent experiments concerning the possible role of components of the pituitary–adrenocortical axis (ACTH and glucocorticoids) in isolation-induced intermale fighting behavior in laboratory strains of mice are reviewed. A series of experiments which investigate factors that may influence the successful demonstration of this relationship are described. Differences in performances in standard-opponent tests of some outbred strains of albino mice are indicated, as well as an interesting positive correlation between the aggressiveness and the relative adrenal weights of the strains employed. Long-acting preparations of both ACTH and ACTH 4–10, injected throughout a period of isolation, suppressed fighting behavior in intact TO-strain mice in subsequent standard-opponent and trained-fighter tests. After it had been confirmed that vigorous isolation-induced fighting could be obtained in bilaterally castrated mice which had been subcutaneously implanted with testosterone pellets, the effects of long-acting preparations of ACTH, ACTH 4–10, ACTH 1–10, and ACTH 4–10 D-phe on the fighting behavior of such animals were studied. A significant suppression of fighting behavior was evident only with respect to ACTH, suggesting that ACTH 4–10 may have its action on this behavior in a manner rather different from that of the parent molecule. Some evidence was also obtained indicating that the zinc used in the preparation of long-acting injections of ACTH and its analogs may also cause a decline in the level of fighting behavior, in a standard-opponent test, in TO-strain mice which had been castrated and testosterone implanted. While such a finding does not affect the validity of the recorded behavioral influences of ACTH and ACTH 4–10 described earlier, it does seem likely that the presence of this substance in placebo injections would make the demonstration of the actions of the pep tides difficult, as there would be a low level of fighting in all categories. Rather less impressive results were obtained with respect to the influences of ACTH preparations and zinc on castrated—implanted CFW mice. The studies identify a number of the factors which may influence the successful demonstration of a relationship between the functioning of the pituitary—adrenocortical axis and isolation-induced agonistic behavior in the mouse. A number of general, if tentative, conclusions may also be listed. It seems likely, in spite of the interpretational difficulties caused by what seems to be a complex and rather unstable relationship, that ACTH and glucocorticoids may have profound influences on this type of fighting behavior in this species. One may also conclude that the evidence for an extraadrenal influence of ACTH on this behavior appears stronger as a result of these and related studies and that the actions of ACTH and its analogs on murine fighting behavior may be logically related to the actions of these compounds on the acquisition and extinction of conditioned avoidance reactions in hypophysectomized rats. The possible utility of such actions to the natural territorial habit of the adult male mouse is also indicated.     

Comparing decay rates for accurate and false memories in the DRM paradigm

Although previous studies have consistently reported different forgetting rates for true and false memory when tested with recall, studies comparing the rates of decay for true and false recognition have reported inconsistent results. The present study attempted to clarify this inconsistency by comparing forgetting rates for true and false recognition in addition to addressing methodological differences among the previous studies. Recognition of list items and critical lures was assessed at six delays (2, 5, 10, 15, and 20 min, and 2 days). A comparison of power function slopes across item type provided evidence of slope differences such that false recognition decayed more quickly than true recognition, which is inconsistent with predictions from activation/ source-monitoring and fuzzy tracetheories.     

The effects of divided attention on auditory priming

Traditional theorizing stresses the importance of attentional state during encoding for later memory, based primarily on research with explicit memory. Recent research has begun to investigate the role of attention in implicit memory but has focused almost exclusively on priming in the visual modality. The present experiments examined the effect of divided attention on auditory implicit memory, using auditory perceptual identification, word-stem completion and word-fragment completion. Participants heard study words under full attention conditions or while simultaneously carrying out a distractor task (the divided attention condition). In Experiment 1, a distractor task with low response frequency failed to disrupt later auditory priming (but diminished explicit memory as assessed with auditory recognition). In Experiment 2, a distractor task with greater response frequency disrupted priming on all three of the auditory priming tasks as well as the explicit test. These results imply that although auditory priming is less reliant on attention than explicit memory, it is still greatly affected by at least some divided-attention manipulations. These results are consistent with research using visual priming tasks and have relevance for hypotheses regarding attention and auditory priming.     

Post-conventional moral reasoning and reputation

Kohlberg’s theory of moral development conceives conventional and post-conventional moral reasoning as consecutive levels in a developmental sequence. This claim was examined in terms of the relationship between preference for these two styles of reasoning on the one hand and moral identity as perceived by others (reputation) and as self-perceived and on the other. Participants (n = 172), in groups of four mutual acquaintances, provided ratings of one another’s standing, and estimates of their own standing and reputation, on four trait dimensions (moral responsibility, consideration for others, respect for authority, and political orientation). Post-conventional moral reasoning, assessed using the Defining Issues Test, was not significantly related either to reputation or to self-rating on any dimension except political orientation. Conventional reasoning was related to politics though in the opposite direction, but additionally to both self- and other-ratings of moral responsibility and to the corresponding ratings of respect for authority. Findings do not support the view that the conventional/post-conventional distinction in moral reasoning is a developmental difference. An alternative proposed is that these are independent domains of moral thought, related to quite different aspects of social behaviour and political attitudes.     

Differential evaluation of residential care programmes for minors

In this study, the results achieved by residential care programs for minors were evaluated. Two measurements were taken, nine months apart, from a total of 175 minors using a monthly observation scale of goals from an Individualised Educational Project. It was found that, in the majority of the dimensions analysed, there were improvements, although they were not the same for all the minors or of the same magnitude. The differential analyses show that variables such as reason for admission and duration of stay modify the results obtained. There was no significant relationship with age or sex. These results are discussed in the light of existing literature.     

Integrating Psychotherapeutic Processes with Cognitive Behavioral Procedures

There has been a recent focus on the processes that underlie intervention delivery for children and adolescents throughout the Cognitive-Behavioral Therapy (CBT) literature. Certain process variables have been associated with treatment outcome among youth receiving CBT. Data for these process variables including: the therapeutic alliance or therapeutic relationship, child and parent involvement, other child and therapist variables, and issues of diversity, are reviewed. Based on this data, specific clinical recommendations are made. The treatment relationship as a very important process (VIP), and the facilitation of CBT so that it is real and relevant to youth are emphatically discussed. Process issues in modular CBT are identified. Ultimately, genuine collaborative empiricism and guided discovery preserve the therapeutic relationship as a VIP, and foster the customization of therapeutic tools and the treatment trajectory.     

An evaluation of the effects of response interruption redirection and matched stimulation on vocal stereotypy

Stereotypy is one of the core diagnostic features of autism spectrum disorder and warrants behavioral intervention when it negatively impacts the person's life. The aim of this study was to evaluate the effectiveness of noncontingent matched stimulation (NCR‐M) compared with response interruption redirection (RIRD) on reducing levels of vocal stereotypy in the natural environment. Interventions were compared using an alternating treatments design followed by generalization and maintenance phases, which utilized lay people as instructors. Results showed that both RIRD and NCR‐M resulted in a reduction in vocal stereotypy for three out of four participants within an educational setting. An increase in appropriate vocalizations was found for two out of four participants for both interventions. These results suggest that both NCR‐M and RIRD were effective in reducing levels of vocal stereotypy, yet their effects on appropriate communication remain undetermined. Social validity scores were obtained following the study, which demonstrated that both interventions were met with approval across a variety of measures.     

The association between in-class cultural diversity with empathy and bullying in adolescence: A multilevel mediation analysis

Little is known about the associations between cultural class composition, teacher support for diversity (TSD), cognitive and affective empathy, and bullying and victimisation. Research shows that empathy is negatively associated with bullying and victimisation; and support for diversity and classroom cultural diversity are positively linked to social skills. The present study examines whether cultural diversity and perceived TSD are protective factors against bullying and victimisation, either directly or mediated by empathy. Participants were 897 students from Grades 7 to 10 (M_age = 13.45, SD_age = 1.07, 51.3% girls, 46.7% boys) in 36 classes. Multilevel mediation analyses were conducted. Age and gender were controlled for. More perceived TSD and affective empathy were associated with less bullying. Moreover, the effect of perceived TSD on bullying was partly indirect through affective empathy. Victimisation was not predicted by the study variables. The class level showed no effects. Bullying and victimisation are complex phenomena, which seem to be linked more to individual than to class characteristics. The result that higher perceived TSD was linked to empathy and bullying provides a promising starting point for measures of competence enhancement and bullying prevention.     

Perceptions of Licensure: A Survey of Michigan Genetic Counselors

This study by the Michigan Genetic Counselor Licensure Committee is the first known published documentation of genetic counselors’ beliefs and attitudes about licensure. The response rate from genetic counselors in Michigan was 66% (41/62). Ninety-five percent of respondents were supportive of licensure. Respondents believed licensure would legitimize genetic counseling as a distinct allied healthcare profession (97.5%), increase the public’s protection (75%), and allow genetic counselors to practice independently (67%). While 45% felt licensure would increase counselor involvement in lawsuits, this did not impact licensure support (p?=?0.744). Opinions were split regarding physician supervision and ordering tests. Even though 28% favored physician supervision, there was overwhelming support for genetic counselors performing some components of genetic testing (95%) and ordering some types of genetic tests (82%) independent of a physician. Use of this survey may be helpful in other states to assess genetic counselors’ interest in licensure and for drafting legislation.