Amygdala upregulation of NCAM polysialylation induced by auditory fear conditioning is not required for memory formation, but plays a role in fear extinction

There is much interest to understand the mechanisms leading to the establishment, maintenance, and extinction of fear memories. The amygdala has been critically involved in the processing of fear memories and a number of molecular changes have been implicated in this brain region in relation to fear learning. Although neural cell adhesion molecules (NCAMs) have been hypothesized to play a role, information available about their contribution to fear memories is scarce. We investigate here whether polysialylated NCAM (PSA-NCAM) contributes to auditory fear conditioning in the amygdala. First, PSA-NCAM expression was evaluated in different amygdala nuclei after auditory fear conditioning at two different shock intensities. Results showed that PSA-NCAM expression was increased 24 h post-training only in animals subjected to the highest shock intensity (1mA). Second, PSA-NCAM was cleaved in the basolateral amygdaloid complex through micro-infusions of the enzyme endoneuraminidase N, and the consequences of such treatment were investigated on the acquisition, consolidation, remote memory expression, and extinction of conditioned fear memories. Intra-amygdaloid cleavage of PSA-NCAM did not affect acquisition, consolidation or expression of remote fear memories. However, intra-amygdaloid PSA-NCAM cleavage enhanced fear extinction processes. These results suggest that upregulation of PSA-NCAM is a correlate of fear conditioning that is not necessary for the establishment of fear memory in the amygdala, but participates in mechanisms precluding fear extinction. These findings point out PSA-NCAM as a potential target for the treatment of psychopathologies that involve impairment in fear extinction.     

Effects of Training Volume on Hormones and Mood in Basketball Players

Mood and basal hormone levels were measured before and after a 4-month training period in 20 professional basketball players on 2 different teams. Training volume was daily quantified by intensities, showing that Team 1 trained nearly twofold the volume of Team 2. Apart from the lack of differences between teams in anthropometric and physical variables, results showed mood improvements in the total sample without differences between teams. However, cortisol levels decreased in Team 1 and increased in Team 2, while the free testosterone–cortisol ratio, free testosterone, prolactin, and luteinizing hormone did not show significant changes. Changes in cortisol were positively related to depression and negatively related to training volume. Results suggest that differences exist in sensitivity and/or timing of both psychological and hormonal responses to 2 given volumes of training.     

Cholinergic septo-hippocampal innervation is required for trace eyeblink classical conditioning

We studied the effects of a selective lesion in rats, with 192-IgG-saporin, of the cholinergic neurons located in the medial septum/diagonal band (MSDB) complex on the acquisition of classical and instrumental conditioning paradigms. The MSDB lesion induced a marked deficit in the acquisition, but not in the retrieval, of eyeblink classical conditioning using a trace paradigm. Such a deficit was task-selective, as lesioned rats were able to acquire a fixed-interval operant conditioning as controls, and was not due to nonspecific motor alterations, because spontaneous locomotion and blink reflexes were not disturbed by the MSDB lesion. The deficit in the acquisition of a trace eyeblink classical conditioning was reverted by the systemic administration of carbachol, a nonselective cholinergic muscarinic agonist, but not by lobeline, a nicotinic agonist. These results suggest a key role of muscarinic denervation on the acquisition of new motor abilities using trace classical conditioning procedures. It might also be suggested that muscarinic agents would be useful for the amelioration of some associative learning deficits observed at early stages in patients with Alzheimer's disease.     

Neuropsychological Behavioral Inhibition System (BIS) and Behavioral Approach System (BAS) assessment: a shortened Sensitivity to Punishment and Sensitivity to Reward Questionnaire version (SPSRQ-20)

This research was designed to investigate the items and factor structure of the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) proposed by Torrubia, Avila, Moltó, and Caseras ( 2001 ), as a measure of the behavioral inhibition system and behavioral activation system in Gray's reinforcement sensitivity theory. Recent studies that analyzed this instrument by exploratory and confirmatory factor analysis suggest the need for structural refinement. The Spanish version of the SPSRQ was analyzed by exploratory and confirmatory procedures in calibration (n = 2,102) and validation (n = 746) independent samples. In addition, convergent and discriminant validity was evaluated with the Zuckerman-Kuhlman Personality Questionnaire (Zuckerman, Kuhlman, Teta, Joireman, & Kraft, 1993 ), the Impulsiveness, Venturesomeness and Empathy Inventory (S. B. G. Eysenck, Pearson, Easting, & Allsopp, 1985 ) the Neuroticism, Extraversion and Openness Five Factor Inventory (Costa & McCrae, 1992 ), and the Barratt Impulsiveness Scales (Barratt, 1985 ). Results showed the robustness of a 20-item structure of the SPSRQ, with satisfactory fit adjustment, validity, and reliability. The findings are discussed in terms of the better functioning and sound psychometric properties of the SPSRQ 20-item version for Gray's personality theory.     

Rejected and excluded forevermore, but even more devoted: irrevocable ostracism intensifies loyalty to the group among identity-fused persons

When people are ostrasized (i.e., rejected and excluded) by either an outgroup or an ingroup, they may either withdraw or engage in compensatory activities designed to reaffirm their social identity as a group member. The authors proposed here that individual differences in identity fusion (an index of familial orientation toward the group) would moderate the tendency for people to display such compensatory activity. Consistent with this reasoning, the results of four experiments showed that irrevocable ostracism increased endorsement of extreme, pro-group actions (fighting and dying for the ingroup) among fused persons but not among nonfused persons. This effect emerged when an outgroup ostracized fused individuals due either to their nationality (Experiment 1) or their personal preferences (Experiment 2). Similarly, ostracism by the ingroup amplified the tendency for fused persons to both endorse extreme pro-group actions, refuse to leave the group (Experiment 3), and donate money to an ingroup member (Experiment 4). Finally, compensatory activities emerged even when ostracism was based on being "too good" for the group, suggesting that a desire for self-enhancement does not mediate such activities (Experiment 4).     

On the nature of identity fusion: insights into the construct and a new measure

Previous research has documented the consequences of feeling fused with a group; here we examine the nature of identity fusion. Specifically, we sought to determine what fusion is and the mediating mechanisms that lead fused individuals to make extraordinary sacrifices for their group. Guided by the assumption that fusion emphasizes the extent to which people develop relational ties to the group, we developed a measure designed to capture feelings of connectedness and reciprocal strength with the group. In 10 studies, the newly developed scale displayed predicted relationships with related measures, including an earlier (pictorial) measure of fusion and a measure of group identification. Also as expected, fusion scores were independent of several measures of personality and identity. Moreover, the scale predicted endorsement of extreme progroup behaviors with greater fidelity than did an earlier pictorial measure of identity fusion, which was, in turn, superior to a measure of group identification. Earlier evidence that the personal and social selves of fused persons are functionally equivalent was replicated, and it was shown that feelings of agency and invulnerability mediated the effects of fusion on extreme behavior. Finally, Spanish- and English-language versions of the verbal fusion scale showed similar factor structure as well as evidence of convergent, discriminant, and predictive validity in samples of Spaniards and Americans, as well as immigrants from 22 different countries. This work advances a new perspective on the interplay between social and personal identity.     

Student and faculty gender in ratings of university teaching quality

The aim of this study is to test the assertion that student and faculty gender, together with their possible interaction, have little or almost no real effect on student ratings of university teaching quality, taking into account the diversity of academic disciplines as a modulating variable. A sample of 1,304 student ratings from a university in Madrid, Spain, was selected out of a total of 236,862. The Complutense University Teachers Evaluation Questionnaire was administered to students at the Complutense University of Madrid for assessing teaching quality. This instrument operationalizes two main dimensions in evaluation of teaching in higher education: Teaching Competence and Motivational and Interactive Skills. When the results were analyzed, taking into consideration both possible statistical significance and effect size, they supported the proposed assertion. These results may have implications on certain areas of higher education.     

Clinical utility of the Bem Sex Role Inventory (BSRI) in the Spanish transsexual and nontranssexual population

The aim of the study is to evaluate the usefulness of the Bem Sex Role Inventory (BSRI; Bem, 1974), an overall measurement of the cultural construct of masculinity and femininity, in the psychological assessment of Spanish transsexuals. Seventy male-to-female transsexuals (MF), 51 female-to-male transsexuals (FM), 77 control men, and 79 control women completed the Spanish version of the BSRI. Statistically significant differences between groups were only found on the femininity scale, on which MF transsexuals and control women scored significantly higher than FM transsexuals and control men. The results indicate that (a) only the femininity scale of the BSRI appears to be useful today for evaluating differences in the sex-role identification in Spanish controls and transsexuals; and (b) MF and FM transsexuals score as a function of their gender identity instead of their anatomical sex on the BSRI femininity scale.     

Incidental retrieval-induced forgetting of location information

Retrieval-induced forgetting (RIF) has been studied with different types of tests and materials. However, RIF has always been tested on the items' central features, and there is no information on whether inhibition also extends to peripheral features of the events in which the items are embedded. In two experiments, we specifically tested the presence of RIF in a task in which recall of peripheral information was required. After a standard retrieval practice task oriented to item identity, participants were cued with colors (Exp. 1) or with the items themselves (Exp. 2) and asked to recall the screen locations where the items had been displayed during the study phase. RIF for locations was observed after retrieval practice, an effect that was not present when participants were asked to read instead of retrieving the items. Our findings provide evidence that peripheral location information associated with an item during study can be also inhibited when the retrieval conditions promote the inhibition of more central, item identity information.