Beyond intravenous thrombolysis

The National Institute of Neurological Disorders and Stroke trial of recombinant tissue plasminogen activator has been considered a landmark study in the acute treatment of ischemic stroke. Unfortunately, only a small percentage of all ischemic stroke patients presents to the hospital in time to receive the drug. Moreover, the recannalization rate of a major artery occlusion, such as the proximal middle cerebral artery or top of the internal carotid artery occlusion, after intravenous (IV) thrombolytic therapy has been disappointingly low. Since the Food and Drug Administration's approval of IV plasminogen activator, there have been numerous randomized clinical trials investigating the safety and efficacy of different thrombolytics administered in various time frames. In addition to the IV administration, efforts have been made in order to study the radiographic as well as clinical effects of intra-arterial (IA) thrombolysis. The combination of IV and IA thrombolysis has been studied. For patients who do not qualify for receiving chemical thrombolysis, new devices have been developed for mechanical thrombectomy. Angioplasty and stenting procedures are being performed more frequently than in the past as one of the treatment modalities for acute ischemic stroke patients. Relentless research effort is being made internationally in order to fight the devastating disease which now goes beyond the conventional IV thrombolysis.     

Psychological essentialism and attention allocation: preferences for stereotype-consistent versus stereotype-inconsistent information

People who believe that human attributes are immutable (entity theorists) display preferences for stereotype-consistent over stereotype-inconsistent information (J. E. Plaks, S. J. Stroessner, C. S. Dweck, & J. W. Sherman, 2001). In this article, the authors argue that entity theories are components of broader sets of beliefs that represent differences between people in terms of underlying essences. Consistent with expectations, the authors found that measures of essentialist beliefs (i.e., in the biological basis, discreteness, informativeness, and inherence of human attributes) covaried with the presence of entity theories. Essentialist beliefs as a set were related to stronger preferences for stereotype-consistent information, and this effect was not reducible to the effect of entity theories. The authors propose that research on implicit person theories can be placed within an encompassing framework of psychological essentialism.     

Levinas and the Parent–Child Relation: A Merleau-Pontyian Critique of Applying Levinas's Thought to Developmental Psychology

Central to Emmanuel Levinas's philosophical account of ethics and intersubjectivity is the parent–child relation. Throughout his major texts, paternity, maternity, and education all function as critical motifs that Levinas utilizes to claim that the subject is primordially oriented by a radical passivity and asymmetrical ethical obligation to the other. Further, several scholars, including Claude Lefort, Brian Vandenberg, Diane Perpich, and Joel Krueger, have highlighted Levinas's insights in relation to child development; however, I argue that they have not adequately accounted for the radicality of Levinas's view of original passivity as the essential ground of subjectivity. After explaining Levinas's account of radical passivity in the parent–child relation, I then turn to recent research in child development to evaluate Levinas's view. In light of the current research, I suggest that Merleau-Ponty's account of the parent–child relation not only complements Levinas's work, but it is also essential for incorporating Levinas's thought in psychological models of the parent–child relation.     

Implicit affectivity and rapid processing of affective body language: An fMRI study

Previous research has revealed affect‐congruity effects for the recognition of affects from faces. Little is known about the impact of affect on the perception of body language. The aim of the present study was to investigate the relationship of implicit (versus explicit) affectivity with the recognition of briefly presented affective body expressions. Implicit affectivity, which can be measured using indirect assessment methods, has been found to be more predictive of spontaneous physiological reactions than explicit (self‐reported) affect. Thirty‐four healthy women had to label the expression of body postures (angry, fearful, happy, or neutral) presented for 66 ms and masked by a neutral body posture in a forced‐choice format while undergoing functional magnetic resonance imaging (fMRI). Participants' implicit affectivity was assessed using the Implicit Positive and Negative Affect Test. Measures of explicit state and trait affectivity were also administered. Analysis of the fMRI data was focused on a subcortical network involved in the rapid perception of affective body expressions. Only implicit negative affect (but not explicit affect) was correlated with correct labeling performance for angry body posture. As expected, implicit negative affect was positively associated with activation of the subcortical network in response to fearful and angry expression (compared to neutral expression). Responses of the caudate nucleus to affective body expression were especially associated with its recognition. It appears that processes of rapid recognition of affects from body postures could be facilitated by an individual's implicit negative affect.     

Broad Consent for Research With Biological Samples: Workshop Conclusions

Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health (NIH) Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and timely topic.     

Some future directions for global justice

The fields of global ethics and global justice have expanded considerably over the last two decades and they now cover a wide variety of topics. Given this huge range there are many areas that are ripe for important developments. In this commentary I identify some useful directions for promising exploration in the field of global justice. I argue that expanded dialogue networks would considerably enhance work in philosophy and be beneficial to other disciplines as well. I indicate also how we could develop work on allocating responsibilities for reducing global injustices in useful ways, by considering a wider range of considerations that give rise to responsibilities and expanding the scope of, and audience for, these discussions. I catalog some under-theorized topics that should get more philosophical attention (including the notions of complicity, exploitation, and corruption). In addition, I draw attention to the ways in which a journal such as this one could facilitate a number of important dialogue networks.     

Infants use known verbs to learn novel nouns: Evidence from 15- and 19-month-olds

Fluent speakers’ representations of verbs include semantic knowledge about the nouns that can serve as their arguments. These “selectional restrictions” of a verb can in principle be recruited to learn the meaning of a novel noun. For example, the sentence He ate the carambola licenses the inference that carambola refers to something edible. We ask whether 15- and 19-month-old infants can recruit their nascent verb lexicon to identify the referents of novel nouns that appear as the verbs’ subjects. We compared infants’ interpretation of a novel noun (e.g., the dax) in two conditions: one in which dax is presented as the subject of animate-selecting construction (e.g., The dax is crying), and the other in which dax is the subject of an animacy-neutral construction (e.g., The dax is right here). Results indicate that by 19 months, infants use their representations of known verbs to inform the meaning of a novel noun that appears as its argument.