Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

The Future of Psychology in Departments of Psychiatry

Health care reform has put increasing pressure on faculty of medical schools to become self-supporting. Opportunities for clinical revenue will decrease, but psychologists who are able to generate research funding will become increasingly competitive, albeit as mercenaries, i.e., capable of paying their own way plus generating a profit to support departmental operations and educational programs. Changes in the health care system signal an end to psychiatry's paternalistic relationship to psychology and present opportunities for psychology proactively to influence its future role in health care. Research, political action, and revised scientific mission, models, and roles represent important strategies in the redefining of psychology as a basic science and major profession in health care.     

A study of language functioning in Alzheimer patients

Language functioning in Alzheimer's disease is reviewed and the performance of 25 Alzheimer patients on a standard battery is reported. All these hospitalized patients were aphasic to some degree. As a group, they differed from normals on all language variables, and from stroke patients in terms of higher fluency and lower comprehension. Spontaneous speech showed high incidence of circumlocutions and semantic jargon, but no phonemic paraphasias or target approximations. Syllabic perseverations, shouting, inappropriate laughter, and mutism were late-appearing features. Transcortical Sensory, and Wernicke's aphasias were frequent, but Broca's and Transcortical Motor aphasias notably absent. Extent of language impairment correlated with current length of hospitalization but not age. Reading, writing, and performance scores except praxis, were lower than oral language scores. Findings were discussed in relation to previous results, methodology, and language organization in the brain.     

Repetition Priming Follows Spontaneous but not Prompted Recognition of Familiar Faces

Reaction times to make a familiarity decision to the faces of famous people were measured after recognition of the faces in a pre-training phase had occurred spontaneously or following prompting with a name or other cue. At test, reaction times to familiar faces that had been recognized spontaneously in the pre-training phase were significantly facilitated relative to an unprimed comparison condition. Reaction times to familiar faces recognized only after prompting in the pre-training phase were not significantly facilitated. This was demonstrated both when a name prompt was used (Experiments 1 and 3) and when subjects were cued with brief semantic information (Experiment 2).

Repetition priming was not found to depend on prior spontaneous recognition per se. In Experiment 3, spontaneously recognizing a familiar face did not prime subsequent familiarity judgements when the same face had only been identified following prompting on a prior encounter. In Experiment 4, recognition memory for faces recognized after cueing was found to be over 90% accurate. This indicates that prompted recognition does not yield repetition priming, even though subjects can remember the faces. A fusion of “face recognition unit” and “episodic record” accounts of the repetition priming effect may be more useful than either theory alone in explaining these results.     

REINFORCER VARIATION: IMPLICATIONS FOR MOTIVATING DEVELOPMENTALLY DISABLED CHILDREN

Motivating developmentally disabled children to participate in educational activities can be very difficult. This is especially true for children diagnosed autistic. Because there is some evidence to suggest that stimulus variation may influence motivation, the present study investigated the effects of constant vs. varied reinforcer presentation on correct responding and on-task behavior. Results from a reversal design showed declining trends in both correct responding and on-task behavior when the same reinforcer was consistently presented, whereas, varying the reinforcers produced significantly improved and stable responding. The results are discussed in relation to the literature on stimulus variation and its effects on responsivity.     

The Effects of Alcohol Use and Offender Remorsefulness on Sentencing Decisions1

Presentence reports on 628 offenders were content analyzed. Regression analysis found that remorseful offenders received less severe sentences than non-remorseful offenders. Offenders convicted of minor offenses received more lenient sentences if they had used alcohol in conjunction with their crimes than if they did not use alcohol. The opposite was the case for offenders commiting serious crimes. Remorseful offenders with few prior alcohol-related convictions received less severe sanctioning than non-remorseful offenders with similar conviction records. In contrast, recidivists who were remorseful were dealt with more harshly than their non-remorseful counterparts.     

Cross-cultural model testing: toward a solution of the etic-emic dilemma

A model for the prediction of behavior from attitudinal components, developed by Triandis, was tested with samples of U.S. and Mexican women, and with fertility relevant behaviors. The elements of the model are etic, but the operationalizations of the various variables were done emically. Results support the model in both cultures. While the predictive utility of the model is equivalent in two cultures, there are social class differences on which component of the model is most emphasized. The U.S. upper-middle-class sample and the Mexican upper-middle-class sample emphasized the person's attitude toward the act, while the Mexican lower SES (socio-economic status) sample emphasized the person's normative beliefs (moral obligations).