First and second language in the brain: Neuronal correlates of language processing and spelling strategies

This study explores oscillatory brain activity by means of event-related synchronization and desynchronization (%ERS/ERD) of EEG activity during the use of phonological and orthographic-morphological spelling strategies in L2 (English) and L1 (German) in native German speaking children. EEG was recorded while 33 children worked on a task requiring either phonological or orthographic-morphological spelling strategies. L2 processing elicited more theta %ERS than L1 processing (particularly at bilateral frontal and right posterior parietal sites) which might suggest a stronger involvement of semantic encoding and retrieval of the less familiar L2. The highest level of theta %ERS was revealed for the orthographic-morphological strategy in L2 which might indicate a more intense way of lexical retrieval compared to the phonological strategy in L2 and the orthographic-morphological strategy in L1. Analyses moreover revealed that phonological processing (both in L1 and L2) was associated with comparatively strong left-hemispheric %ERD in the upper alpha frequency band.     

Processing of non-canonical word-order: A case-series on lesion-induced reorganized language and age-effects in typical development

Complex grammatical structures are mastered late in language acquisition. We studied age-effects on performance in object topicalization in 48 typically developing German-speaking participants (aged 8–30 years) and in five patients (children and adolescents) with lesion-induced atypical language representation. Production was tested by a sentence repetition task, comprehension by an acting out task. Three topicalized conditions with differing disambiguation (agreement, case, and case plus agreement) were contrasted with canonical control sentences.     

Later Medieval Metaphysics. Ontology,Language & Logic

WALTER BURLEIGH, Von der Reinheit der Kunst der Logik. Erster Traktat: Von den Eigenschaften der Termini. Übersetzt und mit Einfuhrung und Anmerkungen herausgegeben von Peter Kunze. Lateinisch-deutsch. (Philosophische Bibliothek, Nr. 401 .) Hamburg: Felix Meiner, 1988. xlvii + 269 pp. 64 DM.     

A multitrait–multimethod study of assessment instruments for complex problem solving

Recently published studies on Complex Problem Solving (CPS) suggest that assessments of CPS using multiple complex systems are only moderately related to tests of classical cognitive abilities. Further, CPS assessments show incremental validity beyond tests of other cognitive abilities when predicting relevant outcomes. However, these empirical accounts have relied on single CPS assessment instruments. We do not know whether these findings will generalize to the construct level across different CPS assessment instruments. To answer this question, we tested a sample of N = 339 German university students who completed three CPS assessment instruments based on multiple complex systems (MicroDYN, the Genetics Lab, and MicroFIN) and the matrices subtest of the Intelligence Structure Test as measure of reasoning. Students further reported their school grades. Analyses including latent multitrait–multimethod models provided support for the conceptualization of CPS as a complex cognitive ability. Results indicated that different CPS assessment instruments showed sufficient convergent validity (with a consistency mostly between .50 and .60). In addition, we found evidence for the divergent validity of CPS from reasoning (reasoning predicted two CPS facets, knowledge and control, β_KNOW = .49 and β_CON = .53, respectively). In the prediction of academic achievement, CPS explained variance in natural science grades after we controlled for reasoning (β_CPS = .22), whereas social science grades were not predicted. Our findings suggest that the validity of CPS generalizes across different measurement instruments.     

Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients

Introduction

Adaptation to changing situations can be mediated by two strategies: (1) Evaluation of a response and (2) Evaluation of outcome values in relation to objects. Previous studies indicate that response shifting is associated with a network comprising the left frontal cortex and parietal cortex connected by the superior longitudinal fascicle, whereas outcome evaluation is associated with a network consisting of the orbitofrontal cortex, amygdala and uncinate fascicle. However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems.

Methods

We analyzed stimulus response shifting and stimulus outcome shifting in two studies, one fMRI-study on healthy participants and one study on patients with MS involving structural MRI (Diffusion Tensor Imaging, Voxel Based Morphometry, Ventricular volumetry). Two tasks were used, identical in presentation but different in instruction, controlling for effects of lower level processing. In the SRS task, participants had to perform a “Go” or “NoGo” response depending on a stimulus change: if the stimulus remained the same, they had to continue with the former type of response, if it changed they had to adapt their response pattern. In the SOS task they had to perform a “Go” response only if the presented stimulus corresponded to that of an internal alternating series.

Results

fMRI findings showed that SRS is related to a bilateral parietal-premotor network. In the left hemisphere the prefrontal cortex was also involved. SOS was lateralized to the right hemisphere, particularly to the anterior temporal pole and amygdala, and the inferior parietal cortex. MS patients impaired on this task suffered from lesions in the right uncinate fascicle and showed an enlarged right frontal lateral ventricle.

Conclusion

With physically identical tasks, a functional neuronal segregation can be demonstrated for stimulus response shifting (bilateral activations with a focus in the left prefrontal cortex) and stimulus outcome shifting (right anterior temporal lobe and right supramarginal gyrus).     

To adjust or not adjust: Nonparametric effect sizes,confidence intervals,and real-world meaning

ObjectivesThe main objectives of this article are to: (a) investigate if there are any meaningful differences between adjusted and unadjusted effect sizes (b) compare the outcomes from parametric and non-parametric effect sizes to determine if the potential differences might influence the interpretation of results, (c) discuss the importance of reporting confidence intervals in research, and discuss how to interpret effect sizes in terms of practical real-world meaning.DesignReview.MethodA review of how to estimate and interpret various effect sizes was conducted. Hypothetical examples were then used to exemplify the issues stated in the objectives.ResultsThe results from the hypothetical research designs showed that: (a) there is a substantial difference between adjusted and non-adjusted effect sizes especially in studies with small sample sizes, and (b) there are differences in outcomes between the parametric and non-parametric effect size formulas that may affect interpretations of results.ConclusionsThe different hypothetical examples in this article clearly demonstrate the importance of treating data in ways that minimize potential biases and the central issues of how to discuss the meaningfulness of effect sizes in research.     

Our world is more than physics: a constructive – critical comment on the current science and theology debate

“Critical realism” is one of the most important positions in the current science and theology debate. An analysis of its origin and meaning leads to the question if this position mostly propagated by physicist-theologians could miss an intrinsic feature of the personal dimension of reality. A deeper meaning of the personal dimension sets human science apart. Taking into account social science's insight that persons responsible for their conclusions and actions drive the process of science, the moral dimension of science has to be emphasized. To integrate these aspects into a coherent position, a more differentiated epistemological model is needed. The solution proposed in this paper is to modify critical realism to constructive-critical realism. Theologically interpreted, constructive-critical realism remembers humankind's purpose to shape nature in cooperation with God and with the means of culture toward increasing realization of freedom in relationship. The argument is widely influenced by an analysis of the works of John Polkinghorne.     

Alternative-based thresholding with application to presurgical fMRI

Functional magnetic reasonance imaging (fMRI) plays an important role in pre-surgical planning for patients with resectable brain lesions such as tumors. With appropriately designed tasks, the results of fMRI studies can guide resection, thereby preserving vital brain tissue. The mass univariate approach to fMRI data analysis consists of performing a statistical test in each voxel, which is used to classify voxels as either active or inactive—that is, related, or not, to the task of interest. In cognitive neuroscience, the focus is on controlling the rate of false positives while accounting for the severe multiple testing problem of searching the brain for activations. However, stringent control of false positives is accompanied by a risk of false negatives, which can be detrimental, particularly in clinical settings where false negatives may lead to surgical resection of vital brain tissue. Consequently, for clinical applications, we argue for a testing procedure with a stronger focus on preventing false negatives. We present a thresholding procedure that incorporates information on false positives and false negatives. We combine two measures of significance for each voxel: a classical p-value, which reflects evidence against the null hypothesis of no activation, and an alternative p-value, which reflects evidence against activation of a prespecified size. This results in a layered statistical map for the brain. One layer marks voxels exhibiting strong evidence against the traditional null hypothesis, while a second layer marks voxels where activation cannot be confidently excluded. The third layer marks voxels where the presence of activation can be rejected.     

Medication for Complex Posttraumatic Disorders

Treatment guidelines and reviews of outcome studies agree that drugs are valuable for moderation of irrational moods and impulsivity that interfere with thoughtfulness and cooperativeness. As such, they empower patients to make good use of psychotherapy for mastery of the risk of betrayal in intimate relationships, which is the typical recurrent traumatic event in complex posttraumatic disorders. Psychotherapy, for its part, has demonstrated correction and lasting remission of disorder in the aftermath of certain kinds of single trauma and promises further development to achieve similar efficacy for complex posttraumatic disorders. This article summarizes the strengths and limitations of each class of psychiatric drugs. It explains how the natural course of complex posttraumatic disorders greatly contaminates observations of medication efficacy and fosters unrealistic expectations for drug development.