BOLD response to motion verbs in left posterior middle temporal gyrus during story comprehension

A primary focus within neuroimaging research on language comprehension is on the distribution of semantic knowledge in the brain. Studies have shown that the left posterior middle temporal gyrus (LPMT), a region just anterior to area MT/V5, is important for the processing of complex action knowledge. It has also been found that motion verbs cause activation in LPMT. In this experiment we investigated whether this effect could be replicated in a setting resembling real life language comprehension, i.e. without any overt behavioral task during passive listening to a story. During fMRI participants listened to a recording of the story “The Ugly Duckling”. We incorporated a nuisance elimination regression approach for factoring out known nuisance variables both in terms of physiological noise, sound intensity, linguistic variables and emotional content. Compared to the remaining text, clauses containing motion verbs were accompanied by a robust activation of LPMT with no other significant effects, consistent with the hypothesis that this brain region is important for processing motion knowledge, even during naturalistic language comprehension conditions.     

Allusive thinking (cognitive looseness) and the propensity to perceive “meaningful” coincidences

This study aimed at evaluating relations between the disposition to make “meaningful” associations between random events and potentially predisposing factors related to a more “loose” cognitive control, that is, loose associative processing (allusive thinking) and poorer inhibition of irrelevant memory content. As the findings of this study suggest, individuals with a higher disposition to perceive coincidences produced a higher rate of unusual associations in the Bridge-the-Associative-Gap test than low scorers, and showed poorer inhibition of no longer relevant memory content in the Recent Probes Task. These relationships were independent from individual differences in paranormal belief. Performance in a random generation task (Mittenecker Pointing Test) yielded no support for an important role of a biased concept of randomness in the perception of coincidences. The findings suggest that common mechanisms may underlie the propensity to perceive meaningful coincidences, cognitive looseness, and positive schizotypy.     

Eye movement suppression interferes with construction of object-centered spatial reference frames in working memory

The brain’s frontal eye fields (FEF), responsible for eye movement control, are known to be involved in spatial working memory (WM).In a previous fMRI experiment (Wallentin, Roepstorff & Burgess, Neuropsychologia, 2008) it was found that FEF activation was primarily related to the formation of an object-centered, rather than egocentric, spatial reference frame. In this behavioral experiment we wanted to demonstrate a causal relationship between eye movement control and manipulation of spatial reference frames. Sixty-two participants recalled either spatial (“Was X in front of Y?”) or non-spatial (“Was X darker than Y?”) relations in a previously shown image containing two to four objects, each with an intrinsic orientation and unique luminance. During half of all recall trials a moving visual stimulus was presented, which participants had to ignore, thus suppressing eye movement. Response times were significantly slower for spatial relations with distraction while there was no effect on non-spatial relations. There was no effect on accuracy, i.e. WM maintenance. This is consistent with the hypothesis that in spatial representations the FEFs are involved in WM content manipulation, such as establishing an object-centered spatial frame of reference.     

Psychosoziale Versorgung von Krebspatienten

Objectives

The aim of this study was to determine rates of psychooncological care for cancer inpatients and outpatients under routine conditions in a large University hospital. The percentage of patients who received care was analyzed and compared with self-rated and expert rated supportive care needs.

Methods

The percentage of inpatients who received psychooncological care was calculated by comparing the number of cancer patients treated at the hospital as documented by the local tumor registry (n=1,979) with the number of patients treated by a psychooncologist in that hospital as documented by the hospital??s psychooncological consultation liaison service. The percentage of outpatients who received psychooncological care was calculated by comparing the number of incident cancer cases as documented by the local tumor registry (n=5,886) with the number of patients who received at least one consultation at the local tumor counseling centre. Supportive care needs were estimated by analyzing data of a prospective patient survey in the same hospital (n=1,803) using the Hospital Anxiety and Depression Scale and single items to determine social burden and the wish for emotional support.

Results

The results showed that 11% of inpatients and outpatients (n=234 and n=638, respectively) received psychooncological care. Social care needs were prevalent in 37% and psychological care needs in 52% of the patients during the stay in hospital and in 42% (social and psychological) 6 months later. Of the patients 41% expressed the need to see a social worker and 29% to see a psychologist. Large differences were found between patients with different tumor entities.

Conclusion

Psychooncological care delivered to cancer patients under routine conditions was below the actual rate required as estimated by screening instruments and as expressed by the patients.     

Illusory correlations revisited: the role of pseudocontingencies and working-memory capacity

Three experiments investigate illusory correlations in a feedback learning paradigm. Diverging from a standard paradigm, in which stimuli consist of joint observations of group-behaviour pairs, participants were asked to guess the group reference of positive and negative stimulus behaviours. They only knew that one group was larger than the other, and the stimulus series soon revealed that positive (negative) behaviours appeared more frequently in the stimulus series than negative (positive) behaviours. Regardless of whether feedback of the actual group reference was provided or not, the predominant valence was more strongly associated with the large than the small group. This illusory-correlation effect was evident in memory-based measures at the end of the stimulus series as well as in the online predictions during stimulus presentation. The strength of illusory correlations increased with decreasing working-memory capacity, operationalized either by an interpersonal differences measure or a cognitive-load manipulation. The occurrence of illusory correlations in the absence of joint observations about group-valence pairs (in the no-feedback condition and in the early phase of the online prediction task) can be explained as a reflection of pseudocontingency inferences.     

Psychoedukation bei Personen mit erh?htem Psychoserisiko

Background

So far only few studies are available which have evaluated the effectiveness of psychoeducation for individuals at risk of psychosis in the early initial prodromal state (EIPS) whereas the benefit of psychoeducation in psychotic patients has been repeatedly confirmed. Thus the aim of this study was to investigate the effect of psychoeducation in individuals with increased risk of psychosis in the EIPS.

Method

A total of 128 help-seeking outpatients in the EIPS participated in a randomized controlled multicentre trial of 12 months of either psychoeducation as part of an integrated psychological intervention (IPI) or supportive counseling (SC). The time to transition to psychosis at 12-month and 24-month follow-up as well as the social adjustment at baseline, time of transition or post-treatment by means of the social adjustment scale (SAS?II) were assessed.

Results

The IPI was superior to SC in preventing progression to psychosis at 12-month (3.2% versus 16.9%, p?=0.008) and 24-month follow-up (6.3% versus 20.0%, p?=0.019). Both treatments resulted in significant pre-post improvements in SAS?II with no significant differences between the two groups.

Conclusions

Psychoeducation as part of an integrated intervention is effective for preventing the onset of psychosis over a 24-month time period in people in an EIPS. Moreover patients at risk of developing first episode psychosis seem to benefit from a specific psychoeducational intervention in the context of other treatments as well as from SC.     

Migranten in sozial schwachen Stadtteilen von Berlin

Background

The aim of the present study was to compare psychological distress and substance use between migrant and non-migrant populations in a socially deprived area of Berlin.

Methods

A population-based random sample stratified for age (18?C57?years) and gender (50% female) was retrieved from the registration office. A total of 143 persons were included in the study. The participation rate was 48.5% when contact was established. Psychological distress was assessed using the General Health Questionnaire (GHQ-28) with its four subscales, somatic symptoms, anxiety/insomnia, social dysfunction and severe depression. Substance use was quantified using the Alcohol Use Identification Disorder Test (AUDIT) and the Fagerstr?m Test for Nicotine Dependence (FTND).

Results

Of the study population 51.3% were first or second generation migrants and lived more often in single households. Migrants had lower educational levels and lower employment rates. The mean scores of migrants and non-migrants did not differ on any of the subscales somatic symptoms, anxiety/depression, social dysfunction or severe depression of the GHQ-28. Non-migrants showed significantly higher risks regarding alcohol use.

Discussion

The present study did not reveal any differences regarding symptom profiles in the spectrum of anxiety and depression between non-migrants and migrants who lived in a socially deprived area. Migrants may compensate higher social risk profiles with lower risks regarding alcohol use. Larger samples have to inform on possible differences regarding smoking and other substances.     

Early signs of memory impairment among multiple sclerosis patients with clinically isolated syndrome

The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and compared them to 49 patients with relapsing remitting MS (RR-MS) displaying mild disability and to a large cohort of age- and education level-matched healthy volunteers(n=230). Results showed that both CIS and RR-MS patients evidenced a disproportionate impairment in the immediate and delayed recall of the second (as compared to the first) of two short narratives of the Logical Memory WMS-III subtest, and reduced performance on the Memory for Digits-Forward. Performance of either group on the executive tasks was not impaired, showing evidence of a reversed speed-accuracy trade-off. Illness duration emerged as a significant predictor of memory and executive task performance. Clinical, psychoemotional, and brain imaging findings were also examined as potential correlates of memory deficits and disease progression among CIS patients. These findings may signify early-onset decline of specific cognitive functions in CIS, which merits regular follow-up assessments and monitoring of psychoemotional adaptation and everyday functioning.     

Graph theory of tower tasks

The appropriate mathematical model for the problem space of tower transformation tasks is the state graph representing positions of discs or balls and their moves. Graph theoretical quantities like distance, eccentricities or degrees of vertices and symmetries of graphs support the choice of problems, the selection of tasks and the analysis of performance of subjects whose solution paths can be projected onto the graph. The mathematical model is also at the base of a computerized test tool to administer various types of tower tasks.