Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients

Introduction

Adaptation to changing situations can be mediated by two strategies: (1) Evaluation of a response and (2) Evaluation of outcome values in relation to objects. Previous studies indicate that response shifting is associated with a network comprising the left frontal cortex and parietal cortex connected by the superior longitudinal fascicle, whereas outcome evaluation is associated with a network consisting of the orbitofrontal cortex, amygdala and uncinate fascicle. However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems.

Methods

We analyzed stimulus response shifting and stimulus outcome shifting in two studies, one fMRI-study on healthy participants and one study on patients with MS involving structural MRI (Diffusion Tensor Imaging, Voxel Based Morphometry, Ventricular volumetry). Two tasks were used, identical in presentation but different in instruction, controlling for effects of lower level processing. In the SRS task, participants had to perform a “Go” or “NoGo” response depending on a stimulus change: if the stimulus remained the same, they had to continue with the former type of response, if it changed they had to adapt their response pattern. In the SOS task they had to perform a “Go” response only if the presented stimulus corresponded to that of an internal alternating series.

Results

fMRI findings showed that SRS is related to a bilateral parietal-premotor network. In the left hemisphere the prefrontal cortex was also involved. SOS was lateralized to the right hemisphere, particularly to the anterior temporal pole and amygdala, and the inferior parietal cortex. MS patients impaired on this task suffered from lesions in the right uncinate fascicle and showed an enlarged right frontal lateral ventricle.

Conclusion

With physically identical tasks, a functional neuronal segregation can be demonstrated for stimulus response shifting (bilateral activations with a focus in the left prefrontal cortex) and stimulus outcome shifting (right anterior temporal lobe and right supramarginal gyrus).     

Probabilism Today: Permissibility and Multi-Account Ethics

In ethics, ‘probabilism’ refers to a position defended by a number of Catholic theologians, mainly in the sixteenth and seventeenth centuries. They held that, when one is uncertain which of a range of actions is the right one to perform, it is permissible to perform any which has a good chance of being the right one—even if there is another which has a better chance. This paper considers the value of this position from the viewpoint of modern ethical philosophy. The unusual nature of probabilism as a theory focusing upon permissibility, rather than right-making properties, is explored and related to some modern attempts to set out ‘satisficing’ and ‘hybrid’ ethical theories. Such theories try to distinguish between what is best and what is permissible, and probabilism can be understood as an alternative way of supplementing a theory of right-making properties by adding to it a theory of permissibility. But a more radical version is also possible, where one abandons any attempt to identify right actions or right-making properties, and instead considers permissibility alone. Accordingly, a ‘multi-account theory’ of permissibility is proposed and defended as a model of how many people actually make moral decisions.     

To adjust or not adjust: Nonparametric effect sizes,confidence intervals,and real-world meaning

ObjectivesThe main objectives of this article are to: (a) investigate if there are any meaningful differences between adjusted and unadjusted effect sizes (b) compare the outcomes from parametric and non-parametric effect sizes to determine if the potential differences might influence the interpretation of results, (c) discuss the importance of reporting confidence intervals in research, and discuss how to interpret effect sizes in terms of practical real-world meaning.DesignReview.MethodA review of how to estimate and interpret various effect sizes was conducted. Hypothetical examples were then used to exemplify the issues stated in the objectives.ResultsThe results from the hypothetical research designs showed that: (a) there is a substantial difference between adjusted and non-adjusted effect sizes especially in studies with small sample sizes, and (b) there are differences in outcomes between the parametric and non-parametric effect size formulas that may affect interpretations of results.ConclusionsThe different hypothetical examples in this article clearly demonstrate the importance of treating data in ways that minimize potential biases and the central issues of how to discuss the meaningfulness of effect sizes in research.     

Therapeutic outcomes in the Welsh Government's school‐based counselling strategy: An evaluation

Aims: The purpose of this study was to evaluate the outcomes of school‐based counselling, as delivered in the Welsh Government's School‐based Counselling Strategy, for reducing psychological distress in young people aged 11–18. Method: The study used a quantitative cohort design, comparing levels of distress on either the Young Person's CORE (YP‐CORE) or the Strengths and Difficulties Questionnaire (SDQ) from baseline to endpoint. Data were available on 3613 episodes of counselling, across 42 datasets. Meta‐analytical procedures were used to identify the mean effect size and predictors of outcomes. Results: Within each dataset, counselling was associated with significant reductions in psychological distress, with a mean effect size (d) of 0.93(95% CI = 0.89–0.97) using a fixed effects model and 1.09 (95% CI = 0.97–1.22) using a random effects model. Datasets using the YP‐CORE had larger effect sizes than those using the SDQ, and datasets with more complete response rates had lower outcomes than those with poorer response rates. Conclusion: The results confirm that school‐based counselling, as delivered in the UK, is associated with significant reductions in psychological distress, comparable to adult counselling and psychotherapy services.     

Our world is more than physics: a constructive – critical comment on the current science and theology debate

“Critical realism” is one of the most important positions in the current science and theology debate. An analysis of its origin and meaning leads to the question if this position mostly propagated by physicist-theologians could miss an intrinsic feature of the personal dimension of reality. A deeper meaning of the personal dimension sets human science apart. Taking into account social science's insight that persons responsible for their conclusions and actions drive the process of science, the moral dimension of science has to be emphasized. To integrate these aspects into a coherent position, a more differentiated epistemological model is needed. The solution proposed in this paper is to modify critical realism to constructive-critical realism. Theologically interpreted, constructive-critical realism remembers humankind's purpose to shape nature in cooperation with God and with the means of culture toward increasing realization of freedom in relationship. The argument is widely influenced by an analysis of the works of John Polkinghorne.     

Alternative-based thresholding with application to presurgical fMRI

Functional magnetic reasonance imaging (fMRI) plays an important role in pre-surgical planning for patients with resectable brain lesions such as tumors. With appropriately designed tasks, the results of fMRI studies can guide resection, thereby preserving vital brain tissue. The mass univariate approach to fMRI data analysis consists of performing a statistical test in each voxel, which is used to classify voxels as either active or inactive—that is, related, or not, to the task of interest. In cognitive neuroscience, the focus is on controlling the rate of false positives while accounting for the severe multiple testing problem of searching the brain for activations. However, stringent control of false positives is accompanied by a risk of false negatives, which can be detrimental, particularly in clinical settings where false negatives may lead to surgical resection of vital brain tissue. Consequently, for clinical applications, we argue for a testing procedure with a stronger focus on preventing false negatives. We present a thresholding procedure that incorporates information on false positives and false negatives. We combine two measures of significance for each voxel: a classical p-value, which reflects evidence against the null hypothesis of no activation, and an alternative p-value, which reflects evidence against activation of a prespecified size. This results in a layered statistical map for the brain. One layer marks voxels exhibiting strong evidence against the traditional null hypothesis, while a second layer marks voxels where activation cannot be confidently excluded. The third layer marks voxels where the presence of activation can be rejected.     

Conditioned suppression/avoidance as a procedure for testing hearing in birds: The domestic pigeon (Columba livia)

Although the domestic pigeon is commonly used in learning experiments, it is a notoriously difficult subject in auditory psychophysical experiments, even those in which it need only respond when it detects a sound. This is because pigeons tend to respond in the absence of sound—that is, they have a high false-positive rate—which makes it difficult to determine a pigeon’s audiogram. However, false positives are easily controlled in the method of conditioned suppression/avoidance, in which a pigeon is trained to peck a key to obtain food and to stop pecking whenever it detects a sound that signals impending electric shock. Here, we describe how to determine psychophysical thresholds in pigeons using a method of conditioned suppression in which avoidable shock is delivered through a bead chain wrapped around the base of a pigeon’s wings. The resulting audiogram spans the range from 2 to 8000 Hz; it falls approximately in the middle of the distribution of previous pigeon audiograms and supports the finding of Kreithen and Quine (Journal of Comparative Physiology 129:1–4, 1979) that pigeons hear infrasound.     

Perfectionism and athlete burnout in junior elite athletes: the mediating role of coping tendencies

Abstract

Recent research indicates that some dimensions of perfectionism are positively related to athlete burnout, whereas others are negatively related to athlete burnout. The divergent relationship between these dimensions of perfectionism and athlete burnout may be explained by different coping tendencies. The present investigation examined whether different coping tendencies mediate the relationship between self-oriented and socially prescribed perfectionism and burnout. Two-hundred and six junior elite athletes (M age=15.15 years, SD=1.88 years, range=11–22 years) completed measures of self-oriented and socially prescribed perfectionism, coping tendencies, and athlete burnout. Structural equation modeling indicated that the relationship between dimensions of perfectionism and athlete burnout was mediated by different coping tendencies. Higher levels of socially prescribed perfectionism was related to higher levels of avoidant coping which, in turn, was related to higher levels of athlete burnout. In contrast, higher levels of self-oriented perfectionism was related to higher levels of problem-focused coping and lower levels of avoidant coping which, in turn, was related to lower levels of athlete burnout. The findings suggest that different coping tendencies may underpin the divergent relationship between self-oriented and socially prescribed dimensions of perfectionism and athlete burnout.     

Medication for Complex Posttraumatic Disorders

Treatment guidelines and reviews of outcome studies agree that drugs are valuable for moderation of irrational moods and impulsivity that interfere with thoughtfulness and cooperativeness. As such, they empower patients to make good use of psychotherapy for mastery of the risk of betrayal in intimate relationships, which is the typical recurrent traumatic event in complex posttraumatic disorders. Psychotherapy, for its part, has demonstrated correction and lasting remission of disorder in the aftermath of certain kinds of single trauma and promises further development to achieve similar efficacy for complex posttraumatic disorders. This article summarizes the strengths and limitations of each class of psychiatric drugs. It explains how the natural course of complex posttraumatic disorders greatly contaminates observations of medication efficacy and fosters unrealistic expectations for drug development.     

The development of stranger fear in infancy and toddlerhood: normative development,individual differences,antecedents, and outcomes

Despite implications that stranger fear is an important aspect of developing behavioral inhibition, a known risk factor for anxiety, normative and atypical developmental trajectories of stranger fear across infancy and toddlerhood remain understudied. We used a large, longitudinal data set (N = 1285) including multi‐trait, multi‐method assessments of temperament to examine the normative course of development for stranger fear and to explore the possibility that individual differences exist in trajectories of stranger fear development between 6 and 36 months of age. A latent class growth analysis suggested four different trajectories of stranger fear during this period. Stable, high levels of stranger fear over time were associated with poorer RSA suppression at 6 months of age. Rates of concordance in trajectory‐based class membership for identical (monozygotic) and fraternal (dizygotic) twins, along with associations between atypical stranger fear development and greater anxiety‐related maternal characteristics, suggested that individual differences in developmental trajectories of stranger fear may be heritable. Importantly, trajectories of stranger fear during infancy and toddlerhood were linked to individual differences in behavioral inhibition, with chronically high levels of stranger fear and sharp increases in stranger fear over time related to greater levels of inhibition than other developmental trajectories.